Infliximab efficacy prediction method and terminal equipment for Crohn's disease

A technology for Crohn's disease and prediction methods, applied in medicine or prescriptions, drug reference, healthcare informatics, etc., can solve problems such as expensive side effects, increased risk of infection and lymphoproliferative diseases, and nervous system damage. Accurately know the effect

Active Publication Date: 2021-08-03
SHENZHEN UNIV
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  • Abstract
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Problems solved by technology

However, 13%-40% of samples treated with IFX do not respond to the drug early in treatment, and IFX is expensive and has...

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  • Infliximab efficacy prediction method and terminal equipment for Crohn's disease
  • Infliximab efficacy prediction method and terminal equipment for Crohn's disease
  • Infliximab efficacy prediction method and terminal equipment for Crohn's disease

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Embodiment Construction

[0023] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terminology used herein in the description of the present invention is only for the purpose of describing specific embodiments, and is not intended to limit the present invention.

[0025] Previous studies have shown that some indicators such as clinical data, serum, ...

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Abstract

The present invention relates to a method for predicting drug efficacy of infliximab for Crohn's disease and a terminal device. The method comprises: acquiring arterial phase scanning images of intestinal lesions, and extracting radiomics features from the arterial phase scanning images ; Inputting the radiomics features into the trained prediction model to obtain the drug effect prediction result, wherein the prediction model is a prediction model established by using a support vector machine classifier. By acquiring arterial phase scan images of intestinal lesions, extracting radiomics features, and then inputting the radiomics features into the trained prediction model, in order to accurately know the infliximab of Crohn's disease efficacy.

Description

technical field [0001] The invention relates to the technical field of drug effect monitoring, in particular to a method for predicting drug effect of Crohn's disease infliximab, a computer-readable storage medium and a terminal device. Background technique [0002] Crohn's disease (CD) is a chronic inflammatory bowel disease (Inflammatory bowel disease, IBD) whose etiology and pathogenesis are not yet fully understood. The residual rate is high, seriously affecting the quality of life of the sample. [0003] Currently, there is no cure for CD in clinical practice. Moderately or severely active CD is generally treated with glucocorticoids, but a small number of samples are ineffective in corticosteroid therapy, and some samples are hormone-dependent. The existing consensus does not recommend the use of hormones as a long-term maintenance treatment for CD, and those who are ineffective or dependent on hormone therapy are traditionally treated with immunosuppressants. Thiop...

Claims

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Application Information

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IPC IPC(8): G16H20/10G16H30/00G16H50/70G16H70/40G06K9/62
Inventor 黄炳升袁程朗李雪华钟英奎张乃文张洪源罗梓欣冯盛宇曾英候陈白莉冯仕庭陈旻湖李子平
Owner SHENZHEN UNIV
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