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A fraction collection system and method

A technology of fraction collection and fractionation, which is applied in the field of chromatographic systems and control systems, and can solve problems such as valve pollution and difficult compensation of delay volume

Pending Publication Date: 2021-05-11
CYTIVA SWEDEN AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There can also be concerns about contamination in the valve
The difference in delay volume through the valve to waste and through the valve and subsequent tubing to the fraction outlet will be difficult to compensate and there is a risk of valuable material loss and / or mixing

Method used

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  • A fraction collection system and method
  • A fraction collection system and method
  • A fraction collection system and method

Examples

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Embodiment Construction

[0029] as background, Figure 1a and Figure 1b The basic components of a typical fraction collector 1 are schematically shown. Figure 1a shows a rotating type collector 1, while Figure 1b A collector 1' of the X-Y translation type is shown. The collector 1 comprises a tray 2 which is rotatable about its center (shown with arrows). The tray 2 is provided with shelves for storing containers such as tubes 3 . The extension arm 4 holds a dispensing device 5, typically a syringe needle or a plastic tube. The distribution means is in fluid communication with a supply line consisting of an inlet tube 6 through which the liquid to be distributed to the tubes of the fraction collector is supplied from any selected device (not shown) such as a liquid chromatography column .

[0030] During operation, the tray 2 is rotated so that the first tube 3 is placed under the dispensing device 5 . The liquid supplied through the pipe 6 via the distribution device 5 is discharged into the ...

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PUM

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Abstract

A method for fraction collection and a fraction collection system (100) comprising: - a dispensing device (23) including an outlet (24) configured for dispensing fractions of a liquid received from a connected system; - plural receptacles (25) configured for receiving one or more of said fractions, wherein the receptacles (25) and the dispensing device (23) are movable in relation to each other into a number of different positions such that the dispensing device (23) is capable of dispensing a respective fraction of said liquid into one or more of the receptacles (25); - a waste collection device (27), which is arranged in the fraction collection system (100) such that it is movable into at least a first and a second position wherein, in said first position, an inlet (29) of the waste collection device (27) is positioned below the outlet (24) of the dispensing device (23) such that liquid being dispensed from the outlet (24) of the dispensing device (23) is received in the waste collection device (27) and wherein, in the second position, the inlet (29) of the waste collection device (27) is not positioned below the outlet (24) of the dispensing device (23) such that fractions being dispensed from the dispensing device(23) can be received in one or more of the receptacles (25).

Description

technical field [0001] The present invention relates to fraction collection systems, methods for fraction collection, chromatography systems and control systems. Background technique [0002] Fraction collectors are widely used in many applications, such as in the field of liquid chromatography. Fraction collectors are used to distribute fractions of a liquid stream to multiple containers. The containers are typically configured as test tubes mounted in racks or as recesses formed in plates. Fraction collectors can be distinguished by two main principles of operation: rotatable collectors, in which the container is fed towards the dispensing device by a rotary motion; and X-Y collectors, in which the container is fed towards the dispensing device by a linear movement in one or two directions supply. Of course, these principles are the same as those for fraction collectors where the dispensing device moves while the container is stationary. [0003] Regardless of the type...

Claims

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Application Information

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IPC IPC(8): B01D15/24G01N30/80
CPCG01N30/80B01D15/247B01D15/24G01N30/82
Inventor N·斯塔夫斯特罗姆
Owner CYTIVA SWEDEN AB