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Antimicrobial susceptibility testing using microdroplets

A technology for antimicrobial agents and microorganisms, which is applied in the field of measuring the minimum inhibitory concentration of antimicrobial agents and sensitive compositions, and can solve problems such as patient outcome differences

Pending Publication Date: 2021-05-11
BECTON DICKINSON & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Every hour lost before proper treatment is administered can lead to major differences in patient outcomes

Method used

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  • Antimicrobial susceptibility testing using microdroplets
  • Antimicrobial susceptibility testing using microdroplets
  • Antimicrobial susceptibility testing using microdroplets

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Embodiment Construction

[0019] Increased antimicrobial resistance and degradation of the antimicrobial pipeline have created a global public health crisis in which an increasing number of patients are infected with antimicrobial resistant bacteria. Appropriate antimicrobial therapy that can be deployed within hours of the onset of infection can positively impact patient outcomes. However, current infection identification practices require an inordinate amount of time. Therefore, there is a great need for more rapid antimicrobial susceptibility tests, preferably tests that can identify specific antimicrobial susceptibility within hours of drawing a blood sample. This type of rapid test would thus allow physicians to initiate optimal drug therapy from the outset, rather than starting with suboptimal or totally ineffective antimicrobials, thereby greatly improving clinical responsiveness. A major effort to improve current antimicrobial susceptibility testing (AST) practices is aimed at reducing target ...

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Abstract

Provided herein are compositions, methods, systems and / or kits for measuring microbial viability in a sample. Certain embodiments of the present disclosure are related to detection tests comprising compositions, methods, systems and / or kits for measuring an antimicrobial minimum inhibitory concentration and for measuring microbial susceptibility to the antimicrobial. Certain embodiments of the present disclosure are related to detection tests comprising compositions, methods, systems and / or kits for assessing microbial proliferation in a sample.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 719,290, filed August 17, 2018, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure generally relates to detection tests including compositions, methods, systems and / or kits for determining the susceptibility of microorganisms in a sample to antibiotics. Certain embodiments of the present disclosure relate to assays comprising compositions, methods, systems and / or kits for measuring minimum inhibitory concentrations of antimicrobial agents. Background technique [0004] Microbial infections strike and kill millions of people every year. Even in the most advanced clinical microbiology laboratories, a rigorous diagnosis of the pathogen type usually takes days to obtain. Furthermore, patients initially receiving inappropriate therapy exhibit lower survival rates than patients treated with opt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00
CPCC12Q1/18C12Q1/04
Inventor K·维德马尔D·赛巴R·布哈特M·沃尔夫冈P·贝尔
Owner BECTON DICKINSON & CO