1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use
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A compound, -R2 technology, applied in the direction of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, and drug combinations, which can solve the problems of complex toxicity assessment and affecting developability.
Pending Publication Date: 2021-05-14
现代生物科学有限公司
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In addition, biarylsulfonamide metabolites acted as metabolic inducers in rats, complicating the assessment of their toxicity in rodents, which in turn may affect the compound's developability for use in humans
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[0113] Some embodiments of the invention include the following:
[0114] (1) Compounds of the following formula:
[0115]
[0116] or a pharmaceutically acceptable salt or solvate thereof;
[0129] -R 3C independently saturated linear or branched C 1-3 alkyl;
[0130] -R 3F independently satura...
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Abstract
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.
Description
[0001] related application [0002] This application relates to British (GB) patent application No. 1813312.4 filed on August 15, 2018, the contents of which are incorporated herein by reference in its entirety. technical field [0003] The present invention relates generally to the field of therapeutic compounds. More specifically, the present invention relates to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanols and 1-methyl-4-[[4-(2- Pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds), which are useful, for example, in the treatment of disorders (e.g., diseases) including, for example, multiple myeloma, diffuse large B-cell Lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy-resistant cancer, radiation-resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriasis Arthritis, psoriasis, ulcerative colitis, Crohn's disease, sy...
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