Synergistic transcription factors to induce high resistance transendothelial barrier

A technology for transcription factors and endothelium, applied in the field of transcription factors, can solve problems such as difficult to apply to drug development, difficult to reproduce accurately, and highly complex models.
CN112805370APending Publication Date: 2021-05-14F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Publication Date
2021-05-14

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Abstract

This application relates to transcription factors capable of increasing transendothelial barrier integrity. Moreover, this application relates to the use of vectors encoding such transcription factors and cells comprising such vectors.
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Description

technical field

[0001] The present application relates to transcription factors capable of increasing the integrity of the transendothelial barrier. Furthermore, the present application relates to the use of vectors encoding such transcription factors and cells comprising such vectors. Background technique

[0002] Endothelial cell (EC) development begins early in development and undergoes independent developmental steps, each of which leads to a more specialized EC type and eventually to a fully functional specialized EC as the organ becomes vascularized (Potente M, Makinen T . Nature reviews Molecular cell biology. 2017; 18(8): 477-94, Dejana E, Hirschi KK. 2017; 8: 14361). ECs of the blood-brain barrier (BBB) ​​are specialized in that they form a very high-resistance barrier through the expression of tight junctions (Dejana E, Tournier-Lasserve E, Weinstein BM. Developmentalcell. 2009;16(2):209- twenty one). Transcription factors are one of the master regulators of gen...

Claims

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