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Centipeda minima fingerprint spectrum and construction method thereof

A technology for constructing methods of goose not eating grass, which is applied in the field of traditional Chinese medicine detection, can solve the problems of not being able to fully reflect the integrity and characteristics of goose not eating herb and its preparations, and cannot provide chromatographic information at the same time, so as to achieve effective quality detection Or identification, effective quality inspection, good repeatability and stability

Active Publication Date: 2021-05-28
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Therefore, the purpose of the present invention is to solve the problem that the construction method of goose-buy-eating fingerprints in the prior art cannot provide the chromatographic information of organic acids, flavonoids, and terpenoids in goose-bubivorous at the same time, and cannot fully reflect the Integrity and characteristic problems of herbivorous medicinal materials and their preparations, providing a goose herbivorous fingerprint and its construction method

Method used

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  • Centipeda minima fingerprint spectrum and construction method thereof
  • Centipeda minima fingerprint spectrum and construction method thereof
  • Centipeda minima fingerprint spectrum and construction method thereof

Examples

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Effect test

Embodiment 1

[0053] Embodiment 1 Goose does not eat grass decoction pieces standard decoction freeze-dried powder

[0054] This embodiment provides a preparation method of standard decoction freeze-dried powder of goose not eating grass decoction pieces, comprising the following steps: take goose not eating grass decoction pieces, decoct twice in a casserole, add 12 times the weight of water for the first time to soak For 30 minutes, first boil with high heat, then decoct with low heat for 30 minutes, filter, add 10 times the amount of water for the second time, boil with high heat, then decoct with low heat for 25 minutes, filter, combine the filtrates, concentrate the filtrate (60°C) to the feed liquid Concentrated extract with a ratio of 1:1 (the ratio of solid to liquid is the mass ratio (g / g) of Goose Bubioca decoction pieces to Goose Bubiograss filtrate), freeze-dried in a freeze dryer, and crushed into powder to obtain .

Embodiment 2

[0055] Example 2 Goose does not eat grass formula granules

[0056] This embodiment provides a method for preparing goose-bushi formula granules, comprising the following steps:

[0057] Take goose not eating grass decoction pieces, heat and reflux to extract twice, first add 16 times the weight of water to soak for 30min, heat and reflux to extract for 1.0h, filter, add 14 times the weight of water to extract for 0.5h for the second time, filter, Combine the filtrates, concentrate the filtrates to a relative density of 1.04g / ml-1.12g / ml at 60°C, dry them, add appropriate amount of auxiliary materials, and granulate to obtain the product.

Embodiment 3

[0059] This embodiment provides a method for constructing the fingerprint of goose not eating grass, comprising the following steps:

[0060] (1) Preparation of test solution: get 0.2 g of standard decoction freeze-dried powder of Goose Bushicao decoction pieces prepared in Example 1, accurately weighed, put in a stoppered Erlenmeyer flask, and the precise addition volume percentage is 50% Methanol aqueous solution 10ml, weighed, ultrasonically treated for 30 minutes, taken out, allowed to cool, weighed again, took 50% methanol aqueous solution to make up the lost weight, shaken well, filtered, and took the filtrate as the test product solution.

[0061] (2) Preparation of the reference solution: take 1.0 g of the goose grazing reference medicinal material, put it in a stoppered Erlenmeyer flask, add 50 ml of water, weigh it, heat and reflux for 45 minutes, add water to make up the lost weight, shake well, Filtrate, evaporate the filtrate to dryness, let it cool, add 10ml of ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly provides a centipeda minima fingerprint spectrum and a construction method thereof, and the method can simultaneously detect organic acids, flavonoids and terpenoids in centipeda minima. The method can be used for detecting centipeda minima medicinal materials, centipeda minima decoction pieces or centipeda minima medicinal preparations, meanwhile, the method can be used for comparing differences between the centipeda minima in different producing areas, 14 common peaks are selected according to detection results of the medicinal preparations prepared from the decoction pieces in different producing areas, wherein 11 common peaks are known components. According to the detection method, the quality condition of the centipeda minima medicinal preparation can be monitored from the overall characteristic appearance of the chromatography.

Description

technical field [0001] The invention belongs to the technical field of detection of traditional Chinese medicines, and in particular relates to a fingerprint of goose and herbivore and a construction method thereof. Background technique [0002] Goose Herbivore is the dried whole herb of Compositae plant Goose Herbivore Centipeda minima (L.) A.Br. et Aschers. Its main compounds include volatile oils, sterols, flavonoids, triterpenoids, guaiacolides And pseudo-guaiacolide type, etc., have the effects of diverging wind-cold, dredging the nose, and relieving cough, and are used to treat wind-cold headache, cough, bruises, whooping cough, malaria, acute and chronic rhinitis, and allergic rhinitis. [0003] According to the existing literature reports, goose does not eat grass contains organic acids, flavonoids, terpenes and other chemical components. In "Chinese Pharmacopoeia" 2020 edition, for the first time, the terpenoid compound geranilin A was used as the index component f...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8631G01N30/8686Y02A50/30
Inventor 刘华明张辉谭沛郑晓英赵伟志马鹏岗
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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