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A multi-dimensional optical tweezers calibration device and method based on electric field calibration

A calibration device and calibration method technology, applied in the field of sensor calibration, can solve the problems of particle delivery, optical monitoring difficulties, calibration difficulties, errors, etc., and achieve the effect of simple device, low calibration difficulty and wide application range

Active Publication Date: 2021-07-02
ZHEJIANG LAB +1
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the difficulty of thermal balance calibration under high vacuum, thermal balance calibration is often carried out at a vacuum above 1mbar, and the calibration results may introduce errors when applied to high vacuum
The electric field force calibration method can also be calibrated and calibrated without being affected by the degree of vacuum, but the existing technology for calibrating the three-axis motion signal of particles is realized by loading electrode plates on six sections around the microspheres. The three-dimensional electric field device thus constituted leads to Particle delivery, optical monitoring becomes difficult

Method used

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  • A multi-dimensional optical tweezers calibration device and method based on electric field calibration
  • A multi-dimensional optical tweezers calibration device and method based on electric field calibration
  • A multi-dimensional optical tweezers calibration device and method based on electric field calibration

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Embodiment Construction

[0025] The present invention will be described in detail below with reference to the accompanying drawings and preferred embodiments, and the purpose and effect of the present invention will become clearer. It should be understood that the specific embodiments described here are only used to explain the present invention and are not intended to limit the present invention.

[0026] Such as figure 1 As shown, the multi-dimensional optical tweezers calibration device based on electric field calibration of the present invention includes a laser 1, a beam splitter 2, a polarization adjuster 3, a vacuum cavity 4, an objective lens 5, a parallel electric field application unit 7, and an electric field control unit 8 , the first photodetector 9, the second photodetector 10, the data processor 11;

[0027] The beam splitter 2, the polarization adjuster 3, the objective lens 5, the parallel electric field application unit 7 and the first photodetector 9 are sequentially arranged on the...

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Abstract

The invention discloses a multi-dimensional optical tweezers calibration device and method based on electric field calibration. Utilizing the polarization-dependent characteristics of tightly focused optical traps, a one-dimensional electric field calibration device is proposed to realize the calibration of three-axis electric field forces on particles. The method of the invention makes the microparticle electric field force calibration system compatible with the microparticle delivery and particle detection systems; simplifies the complexity of the device and reduces the calibration complexity.

Description

technical field [0001] The invention relates to the field of sensor calibration, in particular to a multi-dimensional optical tweezers calibration device and method based on electric field calibration. Background technique [0002] Since the optical tweezers technology was pioneered by Arthur Ashkin in the 1970s, as a general tool for trapping and manipulating neutral particles, it has been widely studied and applied in the fields of molecular biology, nanotechnology and experimental physics. The optical tweezers technology can be understood by the simple harmonic oscillator model through the suspended particles of the laser beam. Compared with the traditional oscillator model, the optical tweezers technology has no contact mechanical dissipation; further, unlike the optical tweezers system in the liquid or air medium, it operates in a vacuum The optical tweezers system can realize the complete isolation of the suspended unit from the environment. Based on the above advanta...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G21K1/00G01B7/02G01B21/04G02B27/28
CPCG21K1/006G01B7/02G01B21/042G02B27/28G01N2015/0038G01N15/1434G01N15/1456G01N2015/0046G02B5/3083G02B27/286
Inventor 李翠红陈志明蒋静高晓文傅振海胡慧珠
Owner ZHEJIANG LAB
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