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Method and device for in vivo tissue regeneration on interior surface of hollow organs

An inner surface, organ technology, applied in the field of cell delivery devices, can solve serious problems, lack of early detection and treatment, damage, etc., and achieve the effect of increasing tissue growth

Pending Publication Date: 2021-05-28
BIOSTAGE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although esophageal injury may be a relatively rare event, the occurrence of injury is serious and in the absence of early detection and treatment further complications can precede

Method used

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  • Method and device for in vivo tissue regeneration on interior surface of hollow organs
  • Method and device for in vivo tissue regeneration on interior surface of hollow organs
  • Method and device for in vivo tissue regeneration on interior surface of hollow organs

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Embodiment Construction

[0027] Disclosed herein are new methods of promoting in vivo regeneration of affected areas of the inner surface of cavities using delivery devices for the local delivery of cellular material, which may include stem cell material such as cells of autologous origin. Autologous cells may include mesenchymal stem cells (MSCs), such as adipose-derived mesenchymal stem cells (aMSCs), as desired or needed. It has been found, quite unexpectedly, that stem cells, such as adipose-derived mesenchymal stem cells (aMSCs), when deployed in contact with a target area inside a hollow organ, such as the esophagus, can support tissue regeneration in the affected area of ​​interest and Protect affected or targeted areas such as wounds from the surrounding environment. It has been found that when a delivery device as disclosed herein is positioned in overlying contact with the affected area of ​​the inner surface of a hollow organ, cells such as mesenchymal stem cells (MSCs) are retained, for ex...

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Abstract

Aspects of the disclosure relate methods and a synthetic cell delivery device for treating trauma present relative to the inner surface of a hollow organ such as an esophagus.

Description

[0001] cross reference [0002] This application claims priority and benefit to U.S. Provisional Patent Application Serial No. 62 / 741,544, filed October 5, 2018, and U.S. Provisional Patent Application Serial No. 62 / 740,962, filed October 4, 2018, the entire disclosure of the foregoing Incorporated herein by reference. technical field [0003] The present application relates to cell delivery devices for promoting and / or effecting tissue regeneration in vivo on areas close to the surface of a hollow organ such as the esophagus. Background technique [0004] Although esophageal injury may be a relatively rare event, the occurrence of injury is serious and in the absence of early detection and treatment, further complications can precede. Causes of esophageal trauma can include penetrating or blunt trauma, iatrogenic trauma, lacerations from ingestion of sharp objects, or tissue destruction secondary to swallowing corrosive substances. Esophageal damage can also occur gradual...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/38A61L27/56
CPCA61L2430/22A61L2400/12A61L27/56A61L27/3834A61L27/3882A61L27/18A61L27/16C08L75/04C08L67/02C08L25/06C08L29/04C08L33/08C08L33/12C08L33/20C08L27/12A61L27/26A61L27/34A61L27/3679A61L27/3691A61L27/3695A61L2300/412A61L2420/06A61L2430/34
Inventor 蒙灵辉胡顺福W·佛多尔
Owner BIOSTAGE INC
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