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Rapid screening system, device and method for on-site epidemic prevention detection

A fast, optical detector technology, applied in measurement devices, sampling devices, preparation of samples for testing, etc., can solve the problems of control increase, burden, dependence on laboratory steps, etc., achieve high accuracy and sensitivity, and promote control. Effect

Pending Publication Date: 2021-06-11
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One problem faced in the epidemic prevention work is that some infected people are asymptomatic infected people. This part of the population has no obvious clinical manifestations such as fever and fatigue, but the virus nucleic acid test is positive, which proves that they are indeed infected with the new coronavirus. Strong infectivity, which adds a great burden to the control of the epidemic
Although it has been reported to use SERS technology to directly detect respiratory system-related viruses by introducing noble metal nanomaterials or substrate materials with specific configurations, the detection still relies on expensive Raman equipment and complicated laboratory steps. Not suitable for epidemic prevention work that requires rapid on-site testing

Method used

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  • Rapid screening system, device and method for on-site epidemic prevention detection
  • Rapid screening system, device and method for on-site epidemic prevention detection
  • Rapid screening system, device and method for on-site epidemic prevention detection

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Experimental program
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Effect test

Embodiment 1

[0045] The preparation of embodiment 1 nanochip

[0046] This embodiment provides a method for preparing a SERS nanochip (gold nanochip), the steps are as follows:

[0047] 1) Prepare the gold seed particle dispersion of 16nm with tetrachloroauric acid aqueous solution (25mM), citrate aqueous solution as raw material;

[0048] 2) Prepare a piranha solution according to the ratio of sulfuric acid and hydrogen peroxide at 3:1, heat the silicon wafer to 65°C with a magnetic stirrer, soak it for 30 minutes, then ultrasonically clean it with deionized water for 15 minutes, and dry it with nitrogen;

[0049] 3) Pipette 18.5 μL of 3-aminopropyl-3-methoxysilane into 20 mL of absolute ethanol solution, then add a silicon chip to make it aminated, soak for 1 hour, and dry with nitrogen;

[0050] 4) Subsequent immersion of the aminated silicon wafer into 10 mL of gold seed solution, soaking for 2 hours, and drying with nitrogen gas to obtain a silicon wafer adsorbed by gold particles;

...

Embodiment 2

[0054] Embodiment 2 masks are used for on-site epidemic prevention detection and screening

[0055] This embodiment provides the method for face masks to be used for on-site epidemic prevention detection and screening.

[0056] First, add specially prepared SERS nanochips to the filter membrane of the mask, distribute them to the subjects for normal breathing and use for several hours, and carry out the adsorption and enrichment of virus particles or related substances that may be contained in the exhaled air. Then, the masks are recovered at the epidemic monitoring point, and the Raman spectrum of the nanochip on the mask is collected on-site through the probe of the portable Raman device, and analyzed through the intelligent algorithm model. After the analysis is completed, the mask is disinfected and replaced safely. The mask that fell off. On-site inspection flow chart see figure 2 .

[0057] According to the output information of the intelligent algorithm processing m...

Embodiment 3

[0058] Embodiment 3 air blower is used for on-the-spot epidemic prevention detection and screening

[0059] In this embodiment, on-site epidemic prevention detection and screening is carried out by using an air blower, which is similar to an alcohol detector.

[0060] A filter element with a porous fiber structure material needs to be attached to the head of the blower. This filter element will be used as the carrier of the SERS nanochip for attachment and enrichment of virus particles that may be contained in the exhaled gas. The structure diagram of the blower is shown in Figure 4 . At the other end of the blower, the probe of the Raman test device is connected, so that after collecting the exhaled gas of the subject, the Raman spectrum collection and result feedback can be performed immediately. At the same time, the possibility of contamination of the probe is also eliminated through the isolation of the air blower space. In actual detection, the optical signal intellig...

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Abstract

The invention relates to a rapid screening system, device and method for on-site epidemic prevention detection. According to the invention, viruses or other pathogens related to the respiratory system are directly detected by using a surface enhanced Raman scattering technology through a nano material or a substrate material with a specific configuration, and a corresponding classification and recognition algorithm is combined, so that relatively high accuracy and sensitivity can be achieved, different pathogens can be distinguished, and the detection sensitivity is ultrahigh. The screening result can be fed back in real time, and sharing of epidemic prevention information and control of suspected cases are effectively promoted. The device provided by the invention is simple and convenient to operate for detection personnel, and is simple and convenient to use for the detected personnel; through establishment of the database, the screened target virus can be converted. The system, device and method are suitable for rapidly screening novel coronavirus carriers on site, and can play a role in other epidemic prevention work occurring in the future.

Description

technical field [0001] The invention relates to the fields of Raman spectrum detection technology and pathogen screening technology, in particular to a rapid screening method based on the principle of surface-enhanced Raman scattering that can be used for on-site epidemic prevention detection. Background technique [0002] The novel coronavirus is very contagious and spreads mainly through droplets and contact. Infected people usually develop pneumonia, and a few develop acute respiratory distress syndrome with severe respiratory complications and even death. Early screening and diagnosis and timely isolation and control are still the key to preventing the further spread of the epidemic. One problem faced in the epidemic prevention work is that some infected people are asymptomatic infected people. This part of the population has no obvious clinical manifestations such as fever and fatigue, but the virus nucleic acid test is positive, which confirms that they are indeed inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65G01N21/552G01N21/3518G01N21/3504G01N21/33G01N21/25G01N21/01G01N1/40G01N1/34G01N1/22
CPCG01N1/22G01N1/34G01N1/40G01N21/01G01N21/25G01N21/33G01N21/3504G01N21/3518G01N21/554G01N21/658G01N2021/0112
Inventor 王毅刘啸虎张庆文李康黄礼平
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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