A kind of traditional Chinese medicine composition for improving asthenopia, preparation method and application thereof

A composition and a technology for visual fatigue, applied in the field of traditional Chinese medicine, can solve the problems of inconspicuous drug effects and complicated prescriptions, and achieve the effects of uniform particles, good stability, and scientific preparation methods

Active Publication Date: 2022-08-02
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional Chinese medicine composition disclosed in the prior art has problems such as complicated prescription and inconspicuous drug effect

Method used

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  • A kind of traditional Chinese medicine composition for improving asthenopia, preparation method and application thereof
  • A kind of traditional Chinese medicine composition for improving asthenopia, preparation method and application thereof
  • A kind of traditional Chinese medicine composition for improving asthenopia, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A preparation method of a crude drug extract for improving asthenopia, comprising the following steps:

[0059] S1: In terms of parts by mass, take 8 g of chrysanthemum and 4 g of safflower, and extract 3 times with 20 times the mass of 40% ethanol under reflux for 2 hours. Combine the alcohol extracts and concentrate under reduced pressure until there is no alcohol smell. Centrifuge it in a centrifuge (25°C, 7000r / min, 30min), take the supernatant, and the supernatant is the alcohol-free extract; the alcohol-free extract is prepared into a sample solution of 0.2g crude drug / mL, pH=4.90 , the weight of the crude drug is based on the weighed API; since ethanol is easy to elute the substances adsorbed by the macroporous resin, the alcohol extract needs to be concentrated under reduced pressure until there is no alcohol smell before loading on the macroporous adsorption resin column. At the same time of concentration, some substances will precipitate, so it is necessary to...

Embodiment 2

[0062] A preparation method of a crude drug extract for improving asthenopia, comprising the following steps:

[0063] S1: In terms of parts by mass, take 16 g of chrysanthemum and 12 g of safflower, and extract 4 times with 10 times the mass of 20% ethanol under reflux for 0.5 h each time, combine the alcohol extracts, and concentrate under reduced pressure until there is no alcohol smell. , centrifugal separation, take the supernatant, the supernatant is the alcohol-free extract;

[0064] S2: Take H1020 macroporous adsorption resin, and pack the column by wet method according to the diameter-to-height ratio of 1:3, then take 0.5BV of alcohol-free extract and load it on the macroporous adsorption resin column at a flow rate of 1BV / h, and then use 0.72BV concentration as 0.05mol / L NaCl solution at a flow rate of 1BV / h to remove impurities from the macroporous adsorption resin column, and then eluted with 1.8BV of 40% ethanol at a flow rate of 1BV / h, discarding the first 0.5BV ...

Embodiment 3

[0066] A preparation method of a crude drug extract for improving asthenopia, comprising the following steps:

[0067] S1: In terms of parts by mass, take 24 g of chrysanthemum and 8 g of safflower, extract 1 time with 25 times the mass of 80% ethanol under reflux, each extraction time is 1.5 h, combine the alcohol extracts, and concentrate under reduced pressure until there is no alcohol smell , centrifugal separation, take the supernatant, the supernatant is the alcohol-free extract;

[0068] S2: Take HPD600 macroporous adsorption resin and pack it into the column by wet method according to the diameter-to-height ratio of 1:5, then take 1.3 BV of alcohol-free extract and load it on the macroporous adsorption resin column at a flow rate of 3 BV / h, and then use a concentration of 1.26 BV as 0.2mol / L NaCl solution removes impurities from the macroporous adsorption resin column at a flow rate of 3BV / h, then elutes with 2.7BV of 80% ethanol at a flow rate of 3BV / h, discards the f...

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Abstract

The invention discloses a traditional Chinese medicine composition for improving asthenopia. The raw materials include chrysanthemum and safflower; the invention also discloses a preparation method of the raw drug extract, which includes taking the raw drug, heating and refluxing extraction with ethanol to obtain alcohol The extract, the alcohol extract is removed from ethanol and then loaded on a macroporous adsorption resin column, and then impurity-removed with NaCl solution, then eluted with ethanol, and the eluate is dried to obtain the crude drug extract; the invention also discloses a traditional Chinese medicine The preparation of the composition is a preparation method of effervescent granules, which comprises taking 5-25 parts of a crude drug extract, 5-25 parts of a diluent, and 50-70 parts of an effervescent disintegrant, and mixing the crude drug extract and the diluent evenly, Divide into two parts, one part is mixed with citric acid to make acid granules, the other part is mixed with sodium bicarbonate wrapped with PEG-6000 to make alkali granules, the acid granules and alkali granules are mixed and granulated to obtain effervescence Granules; the invention also discloses the application of the above-mentioned traditional Chinese medicine composition as a medicine for improving eyestrain, and the effect of improving eyestrain is obvious.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for improving asthenopia, a preparation method and an application thereof. Background technique [0002] Visual fatigue is a syndrome in which eye or systemic organic factors and mental and psychological factors are intertwined. Syndrome, also known as eye fatigue syndrome in clinical. In recent years, with the acceleration of the social rhythm and the increase of pressure in work, life and spirit, the incidence of visual fatigue has been increasing year by year due to long-term work and life on the computer, and the patients with visual fatigue are also more and more prone to Rejuvenation. Asthenopia will not only seriously interfere with the patients' vision and quality of life, but also further lead to age-related macular degeneration, cataracts, blindness and other eye diseases. Therefore, it is of great significance to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/287A61K9/16A61K47/36A61K47/26A61K47/10A61K47/02A61K47/12A61P27/02A61P39/06
CPCA61K36/287A61K36/286A61P27/02A61P39/06A61K9/1623A61K9/1652A61K9/0007A61K9/1611A61K9/1641A61K2236/333A61K2236/55A61K2300/00
Inventor 吴素香石森林任敏霞郑碧莹
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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