Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of multilayer film-coated drug-loaded stent and its preparation method and use

A drug-loading and film-covering technology, applied in the field of medical devices, can solve the problems of inability to achieve local treatment, difficult to control the thickness of the drug film and drug uniformity, and achieve good repeatability, adjustable and controllable process parameters, and drug accumulation. high release effect

Active Publication Date: 2022-07-29
GUANGZHOU JOINCARE RESPIRATORY DRUG ENG TECH CO LTD +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing drug-loaded stents have the following problems: 1. After the single-layer drug-loaded stent is placed in the body, body fluids will elute the exposed drug film of the stent, so that some drugs flow into the pipeline and cannot reach the local area. The role of treatment; 2. It is often difficult to control the thickness of the drug film and the uniformity of the drug when the stent drug film is prepared by dip coating or hot pressing film method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of multilayer film-coated drug-loaded stent and its preparation method and use
  • A kind of multilayer film-coated drug-loaded stent and its preparation method and use
  • A kind of multilayer film-coated drug-loaded stent and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A double-layer film-coated drug-carrying airway stent comprises a stent body, a blank film and a drug-carrying film. The stent body is a metal porous mesh structure, the blank film is coated on the surface of the stent body, and the drug-loaded film is coated on the surface of the blank film. The blank film is a silicone rubber film, and the composition of the drug-loaded film is shown in Table 1:

[0038] Table 1

[0039]

[0040]

[0041] The preparation method of the double-layer covered drug-loaded airway stent is as follows:

[0042] The silicone rubber was dissolved in petroleum ether, and the solution viscosity was 10.28 cp; the bare metal stent was dipped in the silicone rubber solution for 10 minutes, and the dipping was repeated 3 times. Take it out and place it in an electric blast drying oven to dry at 120°C, and a blank film is formed on the surface of the bracket;

[0043] According to the prescription quantity specified in Table 1, the silicone r...

Embodiment 2

[0053] A double-layer film-coated drug-carrying airway stent comprises a stent body, a blank film and a drug-carrying film. The stent body is a metal porous mesh structure, the blank film is coated on the surface of the stent body, and the drug-loaded film is coated on the surface of the blank film. The blank film is a silicone rubber film, and the composition of the drug-loaded film is shown in Table 3:

[0054] table 3

[0055] component 2-1 2-2 2-3 2-4 2-5 Paclitaxel / g 0.10 0.10 0.10 0.10 0.10 Povidone K90 / g 0.06 0.20 0.30 0.30 0.50 Silicone rubber / g 1.84 1.70 1.60 1.60 1.40

[0056] Note: Povidone K90 in 2-4 was replaced with polyethylene glycol 1000.

[0057] The preparation method of the double-layer covered drug-loaded airway stent is as follows:

[0058] The silicone rubber was dissolved in petroleum ether, and the viscosity of the solution was 10.28 cp; the bare metal stent was dipped in the silicone rubber solution ...

Embodiment 3

[0069] A double-layer film-coated drug-carrying airway stent comprises a stent body, a blank film and a drug-carrying film. The stent body is a metal porous mesh structure, the blank film is coated on the surface of the stent body, and the drug-loaded film is coated on the surface of the blank film. The blank film is a silicone rubber film, and the components of the drug-loaded film are: 0.10 g paclitaxel, 0.30 g povidone K90, and 1.60 g silicone rubber.

[0070] The preparation method of the double-layer covered drug-loaded airway stent is as follows:

[0071] The silicone rubber was dissolved in petroleum ether, and the viscosity of the solution was 10.28 cp; the bare metal stent was dipped in the silicone rubber solution for 10 minutes, and the dipping was repeated 3 times. Take it out and place it in an electric blast drying oven to dry at 120°C, and a blank film is formed on the surface of the bracket;

[0072] According to the above recipe quantity, the silicone rubber...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The present invention provides a multilayer film-coated drug-loaded stent and a preparation method and use thereof. The drug-loaded stent of the present application comprises a stent body, a blank film and a drug-loaded film, wherein the blank film is coated and carried on the surface of the stent body, The drug-loaded film is coated and carried on the surface of the blank film. The drug-loaded stent of the present invention solves the problem of restenosis caused by the growth of granulation tissue or tumor cells by releasing the drug.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a multi-layer film-coated drug-carrying stent and a preparation method and application thereof. Background technique [0002] Tracheal stenosis is a common respiratory disease caused by endotracheal intubation, infection, trauma, congenital diseases, and malignant tumors. With the increasing incidence of tumors and the widespread application of ventilator-assisted breathing techniques in the treatment of patients with tracheal trauma, the incidence of tracheal stenosis has increased significantly. Clinically, stent intervention is an effective treatment method. However, bare stent placement often irritates the airway mucosa, leading to a series of complications such as granulation tissue hyperplasia and chronic inflammation, resulting in in-stent restenosis. These complications largely limit the clinical application of tracheal stents. [0003] Stent graft refers to coa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/16
CPCA61L31/08A61L31/16A61L2300/416A61L2300/606A61L2300/602
Inventor 金方周劼闻聪甘瑜
Owner GUANGZHOU JOINCARE RESPIRATORY DRUG ENG TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com