Method and device for processing imaging-analysis data

Abstract

Provided are a method and a device for processing image-analysis data, that can standardize measurement data of a target substance even when the measurement data of the target substance and a reference substance cannot be obtained as one measurement data. The device comprises a storage section for storing: first imaging-analysis data, in which measurement data of a target substance, acquired by performing a first predetermined analysis at each of a plurality of measurement points within an analysis target area of a sample, is associated with spatial position information of the measurement point, and second imaging-analysis data, in which measurement data of a reference substance, acquired by performing a second predetermined analysis at each of the measurement points, is associated with spatial position information of the measurement point; and a normalization executer which normalizes the measurement data of the target substance at each measurement point, based on the measurement data of the reference substance acquired at the same measurement point.

Description

technical field [0001] The invention relates to an imaging analysis data processing method and an imaging analysis data processing device. Background technique [0002] Imaging analysis is performed to investigate the distribution of a target substance in an analysis target region such as a biological sample. As one of imaging analysis, there is an imaging mass spectrometry. In imaging mass spectrometry, mass spectrum data is acquired at each of a plurality of measurement points within an analysis target region. Then, the measured intensity values ​​of ions derived from the target substance are extracted from the mass spectrum data obtained at each measurement point, and an image (image analysis result) represented by the color or shade corresponding to the intensity values ​​is created. [0003] The matrix-assisted laser desorption ionization (MALDI) method is widely used in the ionization of biological samples. In the case of a biological sample, the surface of the samp...

AI Technical Summary

Problems solved by technology

Therefore, even if the measured intensity values ​​of ions having characteristic mass-to-charge ratios in the target substance are extracted from the mass spectrum data acquired at each measurement point to create an image, the distribution of the target substance may not be accurately reflected.

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