Nervonic acid microcapsule and preparation method thereof

A technology of nervonic acid and microcapsules, which is applied in the field of nervonic acid microcapsules and its preparation, and can solve problems such as reducing volatility

Active Publication Date: 2021-08-03
秦大伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, because the microcapsules are wrapped with the capsule wall, the preparation can effectively isolate the active components in the environment, reduce volatility, mask bad odors and protect sensitive materials, which solves the problem of the nerve acid tablets in the prior art being exposed to light in the environment. effects of environmental changes

Method used

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  • Nervonic acid microcapsule and preparation method thereof
  • Nervonic acid microcapsule and preparation method thereof
  • Nervonic acid microcapsule and preparation method thereof

Examples

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Embodiment 1

[0026] A kind of nervous acid microcapsules, comprising capsule core and wall material, the composition of capsule core comprises nervous acid and compound emulsifier, and this compound comprises 75 parts by weight of nervonic acid, 15 parts of compound emulsifier, 10 parts of wall material share;

[0027] The purity of nervonic acid in the capsule core is 97.3% (GC);

[0028] Wherein the emulsifying agent adopted is the mixture that monoglyceride and sucrose ester mass ratio are 4:6;

[0029] Wherein the wall material adopted is a mixture of maltodextrin and sodium alginate with a mass ratio of 2:1;

[0030] The preparation method of the corresponding above-mentioned nervous acid microcapsules, the specific steps are as follows:

[0031] 1) Preparation of the capsule core: heat high-purity nervonic acid at a constant temperature of 75°C for 5 minutes, add the compound emulsifier in the amount of the formula, and then add an appropriate amount of hot water at 70°C to mix, an...

Embodiment 2

[0034] A kind of nervous acid microcapsules, including capsule core and wall material, the composition of capsule core includes nervous acid and compound emulsifier, this compound comprises 80 parts by weight of nervous acid, 17 parts of compound emulsifier, wall material 3 share;

[0035] The purity of the nervonic acid in the capsule core was 96.5% (GC).

[0036] The emulsifier used is a mixture of monoglyceride and sucrose ester with a mass ratio of 6:4.

[0037] The wall material used is a mixture of maltodextrin and sodium alginate with a mass ratio of 1:2.

[0038] The preparation method of the corresponding above-mentioned nervous acid microcapsules, the specific steps are as follows:

[0039] 1) Preparation of the capsule core: heat high-purity nervonic acid at a constant temperature of 75°C for 5 minutes, add the compound emulsifier in the amount of the formula, and then add an appropriate amount of hot water at 70°C to mix, and place it in a constant temperature ma...

Embodiment 3

[0042] A nervous acid microcapsule, comprising a capsule core and a wall material. The composition of the capsule core includes nervous acid and a compounded emulsifier. The compound includes 78 parts of nervous acid, 16 parts of a compounded emulsifier, and 6 parts by weight of the compound emulsifier. share.

[0043] The purity of nervonic acid is 96.5% (GC).

[0044] Wherein the emulsifier Tween 80 and PGA used are a mixture of mass ratio 4:6.

[0045] The wall material soy protein isolate and xanthan gum used are a mixture with a mass ratio of 2:1.

[0046] The preparation method of the corresponding above-mentioned nervous acid microcapsules, the specific steps are as follows:

[0047] 1) Preparation of the capsule core: heat high-purity nervonic acid at a constant temperature of 75°C for 5 minutes, add the compound emulsifier in the amount of the formula, and then add an appropriate amount of hot water at 70°C to mix, and place it in a constant temperature magnetic fie...

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Abstract

The invention belongs to the field of novel drugs, and particularly relates to a nervonic acid microcapsule and a preparation method thereof.The microcapsule comprises a capsule core and a wall material, the capsule core comprises nervonic acid and a compound emulsifier, the compound comprises, by weight, 75-80 parts of nervonic acid, 15-17 parts of the compound emulsifier and 3-10 parts of the wall material, and the purity of nervonic acid in the capsule core is 96% or above; the nervonic acid microcapsule fills the gap in the field of nervonic acid microcapsules, effectively improves the treatment dependency of patients in the use process, and can be widely applied to treatment and prevention of brain diseases of encephalopathy patients and children. Meanwhile, as the microcapsule is wrapped by the capsule wall, the preparation can effectively isolate active components, reduce volatility, mask unpleasant odor and protect sensitive materials in the environment, and the problem that nervonic acid tablets in the prior art are influenced by environmental changes such as illumination in the environment is solved.

Description

technical field [0001] The invention belongs to the field of novel drugs, and in particular relates to a nervonic acid microcapsule and a preparation method thereof. Background technique [0002] Yuanbao maple is a unique maple tree species in my country. It belongs to the family Aceraceae and the genus Acer. It has a wide planting range and is widely distributed in North China and Northeast China. Yuanbao maple has a wide range of uses. First of all, the seed kernel of Yuanbao maple contains 25%-27% protein and does not contain starch. It is rare in other plant seeds and is a new resource of high-quality protein. According to the determination, ingot protein contains 9 kinds of amino acids necessary for human body, which is a complete protein. The high-quality food produced is delicious and is an ideal protein resource. Secondly, Yuanbaofeng is a new resource of high-quality edible oil. Its seeds are large in size and high in oil content. The oil content of Yuanbao Maple ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/201A61K47/14A61K47/26A61K47/36A61K47/42A61P25/00A61P25/16A61P25/28
CPCA61K9/5036A61K9/5052A61K9/5089A61K31/201A61K47/14A61K47/26A61P25/28A61P25/16A61P25/00
Inventor 秦硕卿
Owner 秦大伟
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