TIPE3 immunohistochemical detection kit as well as use method and application thereof

An immunohistochemistry and detection kit technology, applied in the field of tumor detection, can solve the problems of assessing the malignancy of pancreatic cancer and the prognosis of patients, so as to predict the degree of malignancy and metastasis potential, good clinical application value and social benefit, and improve survival rate. Effect

Pending Publication Date: 2021-08-20
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inventors found that there is currently no report on the use of immunohistochemical detection of TIPE3 to assess the degree of malignancy of pancreatic cancer and the prognosis of patients

Method used

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  • TIPE3 immunohistochemical detection kit as well as use method and application thereof
  • TIPE3 immunohistochemical detection kit as well as use method and application thereof
  • TIPE3 immunohistochemical detection kit as well as use method and application thereof

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Embodiment

[0061] Using TIPE3 immunohistochemical detection kit to assess the malignant degree of pancreatic cancer and methods of patient prognosis include sample treatment, initial period of test, antibody incubation, color, and observation, the conclusion, specifically divided into the following steps:

[0062] (1) Tissue fixation: After taking the patient's pancreatic cancer sample, in order to maintain the intrinsic morphology and structure, the antigenicity of the tissue cells is stored, and the acid-antibody binding is removed, and the antigen-antibody binding is easy to obtain good dye results. Need a fixed liquid treatment. Common neutral buffer 4% polymethylene solution (also bouin's liquid, MDF liquid, etc.). The tissue fixed time is preferably in L2H, generally should not exceed 24 h. Because with the prolonged time of fixed time, the detection intensity of the tissue antigen will gradually decrease.

[0063] (2) Production: You can do paraffin, and the paraffin is saved, the str...

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Abstract

The invention provides a TIPE3 immunohistochemical detection kit as well as a use method and application thereof, and belongs to the technical field of tumor detection. The research finds that the expression of the TIPE3 in the pancreatic cancer is obviously increased, is closely related to tumor invasion and metastasis potential and is an independent prognosis risk factor of a pancreatic cancer patient, so that the aims of helping to judge the malignant degree of the pancreatic cancer and prognosis of the patient can be fulfilled by detecting the expression of the TIPE3, and the TIPE3 immunohistochemical detection kit is provided. The kit can effectively predict the malignancy degree and metastasis potential of pancreatic cancer, and perform recurrence and metastasis risk grading on pancreatic cancer patients; and meanwhile, the prognosis condition of the patient can be evaluated, so that the survival rate of the pancreatic cancer patient can be improved, an important scientific basis is provided for clinical prevention and treatment of the pancreatic cancer, and therefore, the kit has good clinical application value and social benefits.

Description

Technical field [0001] The present invention belongs to the technical field of tumor detection, particularly relates to the use of a chemical detection kit and method and application TIPE3 immunohistochemistry. Background technique [0002] The information disclosed in the background is only intended to increase the understanding of the overall background of the present invention, and is not necessarily considered to recognize or imply that the information is intended to be a prior art known to those of ordinary skill in the art. [0003] Pancreatic cancer is one of the most malignant tumors of the digestive system, the incidence of occult, rapid progress, the prognosis is poor, the incidence rate is almost equal to mortality. According to the American Cancer Society (ACS) latest statistics show that the expected incidence of pancreatic cancer in second place in the digestive system tumors, and the fourth highest mortality rate of all malignant tumors. Is expected in 2030, will b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/535
CPCG01N33/535G01N33/57438
Inventor 李泽群贾雯羽周岩冰牛军
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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