Method for detecting lidocaine content in lidocaine gel plaster

A lidocaine gel paste, detection method technology, applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems of low separation degree of detection method, hard paste, inability to accurately measure lidocaine content, etc. The effect of high sensitivity, improved stability and strong specificity
CN113295782AActive Publication Date: 2021-08-24NANJING HEALTHNICE MEDICAL TECH +2
0 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING HEALTHNICE MEDICAL TECH
Publication Date
2021-08-24

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a method for detecting the content of lidocaine in a lidocaine gel plaster, which comprises the following steps of: destroying a gel layer and a back lining layer by adopting a methanol soaking and fractional grinding mode so that lidocaine is completely dissolved in methanol, filtering, taking a subsequent filtrate, diluting with a mixed mobile phase to prepare a test solution, and performing high performance liquid chromatography analysis, in the chromatographic analysis process, adopting a 1-10% glacial acetic acid aqueous solution and methanol as a mixed mobile phase for isocratic elution, and optimizing the content and pH of glacial acetic acid in the glacial acetic acid aqueous solution and the proportion of the mobile phase during isocratic elution, so that the stability of lidocaine in a to-be-detected sample is improved, interference caused by a solvent effect is eliminated, the lidocaine content in the lidocaine gel plaster can be accurately determined, and the method is high in specificity, good in repeatability and high in sensitivity.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of drug analysis, and in particular relates to a detection method for lidocaine content in lidocaine gel plaster. Background technique

[0002] Herpes zoster is an infectious skin disease caused by the reactivation of varicella-zoster virus (varicella. Herpes zoster is a common disease in dermatology, and the incidence rate is on the rise. Postherpetic neuralgia (PHN) is a common complication. The incidence of PHN accounts for 5% to 30% of patients with herpes zoster, and there are about 4 million PHN patients in my country. PHN is more common in elderly and immunocompromised patients. The pain site is usually enlarged than the herpes area, and it is common in unilateral chest, trigeminal nerve (mainly ophthalmic branch) or neck. Pain can vary in nature and can be burning, electric shock, knife cutting, acupuncture or tearing. One type of pain dominates, or multiple pains coexist, which obviously disturb...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More