Preparation and preliminary pharmaceutical evaluation methods of compound qi-tonifying and intestine-moistening capsules

An evaluation method and Qi-enhancing technology, applied in capsule delivery, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve intestinal dry constipation with poor effect, increase gastrointestinal motility, and is not suitable for long-term Take and other problems, achieve the effect of increasing the amount of defecation, improving the overall function, and shortening the defecation time

Pending Publication Date: 2021-09-24
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Through the above analysis, the existing problems and defects of the prior art are: the existing intestinal moistening preparations can take effect through the effect of clearing away heat and purging, and long-term use is easy to damage the righteousness, which will aggravate constipation and have side effects; Poor, not suitable for long-term use
[0004] Because most of the existing intestinal moisturisers have defects such as stickiness and poor solubility, this technology uses natural water-soluble dietary fiber pectin as an auxiliary material on the basis of not adding other irritating ingredients, and its water absorption ratio is significantly higher than that of Conventional intestinal emollients can increase gastrointestinal peristalsis, and at the same time remove toxins from the body, so as to prepare intestinal emollients with less dosage and high bioavailability

Method used

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  • Preparation and preliminary pharmaceutical evaluation methods of compound qi-tonifying and intestine-moistening capsules
  • Preparation and preliminary pharmaceutical evaluation methods of compound qi-tonifying and intestine-moistening capsules
  • Preparation and preliminary pharmaceutical evaluation methods of compound qi-tonifying and intestine-moistening capsules

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Experimental program
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Effect test

preparation example Construction

[0055] The preparation method of Compound Yiqi Runchang Capsule provided by the embodiment of the present invention comprises:

[0056] The dry extract powder obtained by extracting raw astragalus, Codonopsis pilosula, Polygonatum odoratum and Citrus aurantium is added into hemp seed fine powder and Yu Liren fine powder to granulate together, and after adding pectin, put it into a capsule shell to obtain the compound Yiqirun Enteric capsules.

[0057] Such as figure 1 As shown, the preparation method of Compound Yiqi Runchang Capsules provided by the embodiments of the present invention comprises the following steps:

[0058] S101, dry extract powder obtained by extracting raw Astragalus membranaceus, Codonopsis pilosula, Polygonatum odoratum and Citrus aurantium;

[0059] S102, adding hemp seed fine powder and Yu Liren fine powder to the obtained dry extract powder, using microcrystalline cellulose as an auxiliary material, and using 95% ethanol as a wetting agent, and gran...

Embodiment 1

[0075] In the present invention, dry extract powder obtained by extracting raw Astragalus root, Codonopsis pilosula, Polygonatum polygonatum and Citrus aurantium is added into hemp seed fine powder and Yu Liren fine powder to jointly granulate, and the angle of repose, bulk density and hygroscopicity are used as indicators to investigate the auxiliary materials The type and dosage of auxiliary materials, together with pectin, are loaded into the capsule shell of No. 0. It lays the foundation for the follow-up trials of Fufang Yiqi Runchang Capsules.

[0076] 1 Main instruments and materials

[0077] 1.1 Drugs and reagents

[0078] The required medicines and reagents are listed in Table 1.

[0079] Table 1 Experimental Drugs and Reagents

[0080]

[0081] Note: The decoction pieces of various flavors of traditional Chinese medicine conform to the relevant regulations of the first volume of the 2015 edition of "Chinese Pharmacopoeia".

[0082] 1.2 Main instruments

[008...

Embodiment 2

[0147] Example 2: Compound Yiqi Runchang Capsules In Vitro Bacteriostasis and Mice Intestinal Propulsion Experimental Research

[0148] To study the in vitro antibacterial effect of Compound Yiqi Runchang Capsule (YQRC) on common intestinal bacteria, and its effect on defecation and intestinal propulsion in mice. The microdilution method was used to measure the MIC value of this capsule against a variety of common clinical pathogenic bacteria to evaluate its antibacterial activity in vitro; the effect of this capsule on the intestinal propulsion rate of 5-week-old male Kunming SPF mice was observed through experiments And on the first defecation time, 6h stool weight and intestinal propulsion rate of 5-week-old male Kunming mice with constipation. To conduct a preliminary study for the pharmacodynamic evaluation of Compound Yiqi Runchang Capsules.

[0149] 1 Main instruments and materials

[0150] 1.1 Drugs and reagents

[0151] The required medicines and reagents are shown...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses preparation and preliminary pharmaceutical evaluation methods of a compound qi-tonifying and intestine-moistening capsule. The compound qi-tonifying and intestine-moistening capsule is composed of fructus cannabis, semen pruni, raw radix astragali, radix codonopsis, fructus aurantii immaturus and radix polygonati officinalis. The preparation method of the compound qi-tonifying and intestine-moistening capsule comprises the following steps of: adding the fructus cannabis fine powder and the semen pruni fine powder into dry extract powder extracted from the raw radix astragali, the radix codonopsis, the radix polygonati officinalis and the fructus aurantii immaturus, granulating together, and after adding pectin, filling into a capsule shell so as to obtain the compound qi-tonifying and intestine-moistening capsule. According to the invention, the pectin is added, the pectin is basically not absorbed after entering the digestive tract, and the pectin forms jelly after absorbing water, so that not only can intestinal moisture be maintained, but also the volume of excreta in the large intestine can be increased so as to stimulate intestinal peristalsis to generate awareness of defecation and take the effect of promoting the medicine effect; and the compound qi-tonifying and intestine-moistening capsule has the effects of tonifying qi, nourishing yin, increasing liquid, moistening dryness, promoting the circulation of qi, removing stagnation and relaxing bowel, is conformity with constipation of gerontal patients, which is caused by deficiency of qi and yin, not only can relax the bowels, but also can improve the overall function of the patients, and takes the effect of treating diseases and solving the root cause.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation and preliminary pharmaceutical evaluation method of a compound Yiqi Runchang capsule. Background technique [0002] At present, constipation (constipation) is a common clinical disease. With the influence of factors such as changes in modern eating habits and increased pressure in social life, the prevalence of constipation is increasing, especially in the elderly. Long-term constipation can lead to many diseases. Chemical drugs are a common way to treat constipation at present. Long-term use of such drugs can easily disturb the regulation of intestinal flora, resulting in dependence and aggravating constipation. Traditional Chinese medicine has definite curative effect on the treatment of constipation disease. But the existing product that contains Chinese medicine composition is mostly used for alleviating the symptom of constip...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K36/8969A61K47/38A61K47/36A61P1/10G06Q10/06
CPCA61K9/4866A61K36/60A61K36/736A61K36/481A61K36/344A61K36/752A61K36/8969A61P1/10G06Q10/0639A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 张晓平田景振侯林崔清华刘帆
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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