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Strong loquat syrup and preparation method thereof

A technology of strong loquat dew and loquat leaves, which can be applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. problems, to achieve the effect of preventing bumping overflow or coking, reducing the damage of molecular structure and reducing viscosity

Pending Publication Date: 2021-10-01
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, sucrose is usually added for boiling during preparation. On the one hand, it is easy to thicken the solution and affect the solubility of auxiliary materials. Quality is not easy to control

Method used

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  • Strong loquat syrup and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A powerful loquat decoction comprising Chinese herbal medicines in the following weights:

[0028] According to the weight ratio of 69:50:15:9:6:6:2.5:600:0.5:0.25:0.15, weigh 69g of loquat leaves, 50g of poppy shell, 15g of Baibu, 9g of Baiqian, 6g of Platycodon grandiflora, and mulberry bark 6g, sodium benzoate 2.5g, sucrose 600g, citric acid 0.5g, mint essence 0.25g, menthol 0.15g;

[0029] The preparation steps of this powerful loquat dew are as follows:

[0030] (1) Water extract: put the loquat leaves at the bottom, add Morus alba, poppy shell, Baibu, Baiqian and Platycodon grandiflorum in turn, add 7 times the weight of water, boil for 1.5h, filter, add water and repeat boiling twice , filter, and combine the filtrates to obtain a water extract;

[0031] (2) Crude extract: the water extract is subjected to adsorption treatment through the macroporous resin, the volume flow rate of the water extract through the macroporous resin is 1.5mL / min, and the mass concen...

Embodiment 2

[0039] According to the same formula of the strong loquat of embodiment 1, the preparation steps of this powerful loquat are as follows:

[0040] (1) Water extract: put the loquat leaves at the bottom, add Morus alba, poppy shell, Baibu, Baiqian and Platycodon grandiflora in sequence, add 9 times the weight of water, boil for 2.5 hours, filter, add water and repeat boiling 3 times , filter, and combine the filtrates to obtain a water extract;

[0041] (2) Crude extract: the water extract is subjected to adsorption treatment through the macroporous resin, the volume flow rate of the water extract through the macroporous resin is 2.5mL / min, and the mass concentration of 4 times the column volume is 45% ethanol solution, 4 times The mass concentration of the column volume is 65% ethanol solution for gradient elution, and the eluents are combined to obtain a crude extract; wherein, the pretreatment method before the use of the resin comprises the following steps:

[0042] (a) addin...

Embodiment 3

[0049] According to the same formula of the strong loquat of embodiment 1, the preparation steps of this powerful loquat are as follows:

[0050] (1) Water extract: put the loquat leaves at the bottom, add Morus alba, poppy shell, Baibu, Baiqian and Platycodon grandiflorum in turn to mix, add 8 times the weight of water, boil for 2 hours, filter, add water and repeat boiling for 2 times, Filter and combine the filtrates to obtain a water extract;

[0051] (2) Crude extract: the water extract is subjected to adsorption treatment through the macroporous resin, the volume flow rate of the water extract through the macroporous resin is 2.0mL / min, and the mass concentration of 3 times the column volume is 45% ethanol solution, 3 times The mass concentration of the column volume is 65% ethanol solution for gradient elution, and the eluents are combined to obtain a crude extract; wherein, the pretreatment method before the use of the resin comprises the following steps:

[0052] (a)...

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Abstract

The invention provides strong loquat syrup and a preparation method thereof, and the preparation method comprises the following steps: (1) adding water into medicinal materials, boiling, filtering, adding water, repeatedly boiling, filtering, and combining filtrates to obtain a water extract; (2) enabling the water extract to pass through macroporous resin, then carrying out gradient elution, and combining eluents to obtain a crude extract; (3) adding water into cane sugar, controlling steam pressure for boiling and cooling, and adding sucrase for enzymolysis to obtain enzymatic hydrolysate; (4) adding the enzymatic hydrolysate into the crude extract, heating, refrigerating, taking supernate, and concentrating to obtain ointment; and (5) adding sodium benzoate into the ointment, boiling, and subsequently blending to obtain a finished product. The strong loquat syrup prepared by the preparation method disclosed by the invention is not only high in syrup yield, but also relatively high in medicinal component content, the stability of the product is relatively good after the strong loquat syrup is placed for a relatively long time, the production process is simple, the equipment requirement is relatively low, the product quality is easy to control, and large-scale industrial production of the strong loquat syrup can be realized.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a strong loquat extract and a preparation method thereof. Background technique [0002] Qiangli Loquat Lotion is a light brown clear liquid, which has the functions of nourishing yin and constricting the lungs, relieving cough and eliminating phlegm, and can be used for bronchitis cough. Poppy husk is added to the loquat dew, because the poppy husk can inhibit the secretion of respiratory glands and cilia movement, and has a good inhibitory effect on severe dry cough and irritating cough, thus forming a powerful loquat dew. However, during the preparation process of Qiangli Loquat Lotion, the ointment formed by concentrating the medicinal liquid has a high consistency, which easily hinders the addition of subsequent excipients, making the compatibility between the excipients and the ointment worse, resulting in a low ointment yield, and the finished product is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/08A61K47/12A61P11/00A61P11/14A61P29/00
CPCA61K36/73A61K36/66A61K36/904A61K36/27A61K36/346A61K36/605A61K9/0095A61K47/12A61P11/14A61P11/00A61P29/00A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2236/19A61K2300/00
Inventor 刘景萍刘全国陈克领韩玉燕吴伟贞
Owner HAINAN HULUWA PHARMA GRP CO LTD
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