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Application of GPX4, NOX1 and ACSL4 in prognostic evaluation of colorectal cancer

A colorectal cancer and prognosis technology, applied in the field of colorectal cancer prognosis evaluation, can solve the problems of clinical characteristics and prognosis evaluation of patients without colorectal cancer

Pending Publication Date: 2021-10-01
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] However, in the prior art, there is no method to evaluate the clinical characteristics and prognosis of colorectal cancer patients based on the expression of GPX4, NOX1 and ACSL4 cells by colorectal cancer markers

Method used

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  • Application of GPX4, NOX1 and ACSL4 in prognostic evaluation of colorectal cancer
  • Application of GPX4, NOX1 and ACSL4 in prognostic evaluation of colorectal cancer
  • Application of GPX4, NOX1 and ACSL4 in prognostic evaluation of colorectal cancer

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Embodiment 1

[0050] The method steps of the present embodiment are as follows:

[0051] a. The 911 wax blocks of colorectal cancer tissues used in this example were all from the Department of General Surgery, Zhongshan Hospital Affiliated to Fudan University. This experiment was approved by the Ethics Committee of Zhongshan Hospital, and each patient signed an informed consent.

[0052] b. Material collection: The 911 specimens required for the experiment were made of wax blocks, and the sampling locations of the 911 colorectal cancer tissues were as follows: figure 1 shown. The specific preparation method of the wax block is as follows: the material is fresh; the size of the obtained tissue block is about 2.0cm×2.0cm×0.3cm; the tissue block with a size of about 0.8cm×0.8cm×0.3cm is cut with a blade. Put it into a disposable plastic embedding frame and mark it with a marker pen. The dehydration step is to put the plastic embedding frame containing the tissue into ethanol with different c...

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Abstract

The invention relates to application of GPX4, NOX1 and ACSL4 in prognostic evaluation of colorectal cancer. The GPX4, NOX1 and ACSL4 are taken as markers, and the clinical characteristics and prognosis of the colorectal cancer patient are evaluated based on the cell expression conditions of the GPX4, the NOX1 and the ACSL4. Compared with the prior art, the method for evaluating the colorectal cancer based on the expression conditions of GPX4, NOX1 and ACSL4 comprises the following steps: firstly, preparing a tumor tissue chip, then carrying out immunohistochemical experiment and immune scoring, carrying out grouping according to the immune score, and finally establishing a ferroptosis score based on the expression conditions of GPX4, NOX1 and ACSL4 and the prognosis of a patient with the colorectal cancer. The three-year, five-year and seven-year survival rates of colorectal cancer patients can be specifically predicted according to different staining score levels. Statistics and analysis are carried out by the method disclosed by the invention, the prognosis of the colorectal cancer patient can be obviously reflected on the basis of the expression of GPX4, NOX1 and ACSL4 cells in the colorectal cancer cytoplasm, and statistical difference exists.

Description

technical field [0001] The invention belongs to the technical field of colorectal cancer prognosis evaluation, and in particular relates to an application of GPX4, NOX1 and ACSL4 in colorectal cancer prognosis evaluation. Background technique [0002] As a common malignant tumor of the digestive tract, colorectal cancer poses a threat to people's health that cannot be underestimated. According to the global tumor epidemiological statistics (GLOBOCAN 2020) released by the International Agency for Research on Cancer (IARC) of the World Health Organization, there will be 1.9316 million new cases of colorectal cancer and 935,200 deaths worldwide in 2020, ranking third among all malignant tumors. place and second place. In recent decades, with the improvement of people's living standards and changes in dietary structure, the incidence of colorectal cancer has gradually increased. [0003] With the continuous deepening of research on colorectal cancer, the prognosis of colorecta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/532
CPCG01N33/57419G01N33/532
Inventor 吕洋汤文涛郑鹏徐宇秋林奇许剑民
Owner ZHONGSHAN HOSPITAL FUDAN UNIV