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A kind of preparation method and application of Morus alba extract

A technology of Cortex Morus alba extract and Cortex Morus alba, applied in the field of medicine, can solve the problems of easy destruction of heat-sensitive active ingredients, low extraction yield of active ingredients, and difficulty in separation and purification, and achieve the regulation of adipocyte secreted factors and inflammatory factors. , Significantly improved curative effect and short extraction time

Active Publication Date: 2020-07-28
HUANGSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is that the current preparation method of Morus alba extract has the disadvantages of low extraction yield of active ingredients, easy destruction of heat-sensitive active ingredients, difficulty in separation and purification, and long extraction time.

Method used

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  • A kind of preparation method and application of Morus alba extract
  • A kind of preparation method and application of Morus alba extract
  • A kind of preparation method and application of Morus alba extract

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1: the preparation method of Morus alba extract

[0027] (1) Raw material pretreatment: Fully dry the raw material of Morus alba, crush the raw material of Morus alba into powder with a pulverizer, pass through a 120-mesh sieve, pack it in a 1000-mesh gauze bag, put it into the reaction kettle, and add 5 times volume of distilled water for 0.5 hour to make the Morus Alba raw material fully absorb water and swell;

[0028] (2) Biological enzymolysis: after the Morus alba raw material in the step (1) fully absorbs water and swells, add the cellulase that dissolves fully with the same volume of the distilled water in the reactor, and the final concentration of the cellulase is 200U / mL, then oscillating enzymatic hydrolysis at 180rpm room temperature for 0.5h;

[0029] (3) Solvent extraction: after oscillating enzymolysis in the step (2) for 0.5-6 hours, continue to add ethanol in the reaction kettle, mix well, make the final concentration of ethanol be 60% by v...

Embodiment 2

[0031] Embodiment 2: the preparation method of Morus alba extract

[0032] (1) Raw material pretreatment: Fully dry the raw material of Morus alba, crush the raw material of Morus alba into powder with a pulverizer, pass through a 120-mesh sieve, pack it in a 2000-mesh gauze bag, put it into the reaction kettle, and add 2 times volume of distilled water for 2 hours to make the Morus alba raw material fully absorb water and swell;

[0033] (2) Biological enzymatic hydrolysis: after the Morus alba raw material in the step (1) fully absorbs water and swells, add the same volume of distilled water as the distilled water to dissolve the sufficient biological enzyme in the reaction kettle, and the final concentration of the biological enzyme is 300U / mL, the biological enzyme is cellulase, hemicellulase, xylanase, and pectinase configured in a ratio of 1:1:1:1, and then oscillating enzymolysis at 180rpm at room temperature for 6h;

[0034] (3) Solvent extraction: after oscillating ...

Embodiment 3

[0036] Embodiment 3: the preparation method of Morus alba extract

[0037] (1) Raw material pretreatment: fully dry the Morus alba raw material, crush the Morus alba raw material into powder with a pulverizer, pass through a 120-mesh sieve, pack it in a 500-mesh gauze bag, put it into the reaction kettle, and add 2 times volume of distilled water for 0.5 hour to make the Morus Alba raw material fully absorb water and swell;

[0038] (2) Biological enzymolysis: after the Morus alba raw material in the step (1) fully absorbs water and swells, add the same volume as the distilled water to dissolve the sufficient biological enzyme in the reaction kettle, and the final concentration of the biological enzyme is 50U / mL, the biological enzyme is configured by cellulase, hemicellulase, and xylanase in a ratio of 1:1:1, and then oscillating enzymolysis at 180rpm at room temperature for 0.5h;

[0039] (3) Solvent extraction: after oscillating enzymolysis for 0.5h in the step (2), conti...

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Abstract

The invention provides a preparing method of cortex mori radicis extract and application of the preparing method of the cortex mori radicis extract in drugs and health care products for preventing and treating obesity and a metabolic syndrome induced by obesity. According to the preparing method of cortex mori radicis extract, the extraction rate of effective components in cortex mori radicis is increased, loss of thermosensitive active components is avoided, the extraction time is short, the energy consumption is small, feed-liquid separation is rapid, the method is simple and easy to operate in the process, and the cortex mori radicis extract is utilized when extraction is conducted. The cortex mori radicis extract is remarkably effective in lowering the weight, body fat, blood lipid and blood glucose, improving glucose tolerance impairment, resisting an oxidative stress and regulating an adipocyte excreted factor level and an inflammatory factor level, therefore can be used as the drugs and health care products for effectively preventing or treating obesity and the metabolic syndrome induced by obesity, and further the source of natural medicine and health care products for preventing and treating the obesity and the metabolic syndrome is expanded.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of Cortex Mori extract and its application in medicines and health care products for preventing and treating obesity and obesity-induced metabolic syndrome. Background technique [0002] In recent decades, with social and economic development and changes in people's lifestyles, the global obesity rate has shown a linear growth trend, and China has now become an obesity superpower. Obesity not only affects the quality of life and body appearance of patients, but more importantly, seriously endangers their health. It is the main cause of coronary heart disease, type II diabetes, stroke, cardiovascular disease, hypertension, abnormal lipid metabolism and cancer. At present, there are many drugs for treating obesity on the market, but the effect of long-term use is not ideal, and there are serious side effects, such as headache, vomiting, stomach pain, and diar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61P3/04A61P3/00A23L33/105A61K129/00
CPCA23V2002/00A61K36/605A61K2236/19A61K2236/333A61K2236/37A23V2250/21A23V2200/30A23V2200/332
Inventor 吴永祥毕淑峰胡晓倩吴丽萍许竟成吕顺清
Owner HUANGSHAN UNIV