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Jinchuangyao containing acronychia pedunculata essential oil and preparation method thereof

An essential oil and reduction technology, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of inducing other side effects, affecting drug effects, and toxins affecting patients, etc., and achieves the effects of avoiding wound infection, maximizing drug efficacy and reasonable compatibility.

Inactive Publication Date: 2021-10-22
海南长永恒生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese invention patent with the application number 201911289269.5 discloses an ointment for clearing away heat and cooling blood, stopping bleeding and reducing swelling, and promoting wound healing and its preparation method. Although it can improve the absorption efficiency of drugs and promote the rapid healing of bleeding points and ulcers, donkey-hide gelatin Compatible with rhubarb, it will affect the effect of medicine, and even produce toxins to affect patients
[0005] The Chinese invention patent with the application number 202011432686.3 discloses a traditional Chinese medicine preparation for sterilizing, reducing inflammation and promoting wound healing and its preparation method. Among them, most of the medicinal materials are cold medicinal materials, which may induce other side effects after being ingested by the human body

Method used

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  • Jinchuangyao containing acronychia pedunculata essential oil and preparation method thereof
  • Jinchuangyao containing acronychia pedunculata essential oil and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1 A kind of preparation method of golden sore medicine A1 containing Jiangzhen essential oil

[0037] The present embodiment provides a kind of preparation method of the golden sore drug A1 containing Jiangzhen essential oil, it comprises the following steps:

[0038] S1. Weigh 23g of Jiangzhenxiang, wash, dry and pulverize, and carry out supercritical carbon dioxide extraction at a flow rate of 57L / h for 1.8h at a temperature of 40°C and a pressure of 35MPa to obtain 16.67g of Jiangzhen essential oil (The oil yield rate is 72.47%);

[0039] S2. Weigh 15g of borax and 24g of talc respectively, pour them into a grinder for grinding, pass through a 200-mesh sieve, re-grind the remaining large particles until all powders pass through a 200-mesh sieve, and then sterilize at 220°C for 6 seconds to obtain 43g of the mixture Material I;

[0040] S3. Weigh 3g of worm tooth medicine, 5g of notoginseng, 2g of salvia miltiorrhiza, 6g of cuttlefish and 7g of dried bloo...

Embodiment 2～6

[0042] The preparation method of the golden sore medicine A2~A6 of embodiment 2~6 containing Jiangzhen essential oil

[0043] The specific steps of the preparation methods of the golden sore medicines A2-A6 containing Jiangzhen essential oil provided in Examples 2-6 are basically the same as those in Example 1, except that some process parameters are different. The specific process parameters are shown in Table 1.

[0044] Table 1: Table of preparation process parameters of golden sore medicines A2-A6 containing Jiangzhen essential oil

[0045]

[0046]

[0047] Other parameters are all the same as in Example 1.

[0048] All the embodiments described in the present invention can be mixed with vaseline to make golden sore medicine ointment and use.

experiment example 1

[0049] Experimental example 1 skin irritation test

[0050] The golden sore drug A1 containing Jiangzhen essential oil prepared in Example 1 of the present invention was used as the test drug, 70% ethanol was used as the reference drug, and distilled water was used as the blank control.

[0051] Healthy white rabbits were selected as experimental animals. Six rabbits were randomly divided into intact skin group and damaged skin group according to sex and body weight, with 3 rabbits in each group.

[0052] Intact skin group: 24 hours before the administration, the rabbits were depilated symmetrically on both sides of the back, with an area of ​​about 50 cm on each side. The upper left half area is distilled water (blank control area), the lower half area is 70% alcohol control area (drug control area), and the right side is golden sore drug A1 (test area). 24 hours after depilation, apply 0.5ml of distilled water to the upper half of the left side of the intact skin group, 0....

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and discloses a Jinchuangyao containing acronychia pedunculata essential oil and a preparation method thereof. The Jinchuangyao is prepared by mixing acronychia pedunculata essential oil, a mixed material I and a mixed material II. The Jinchuangyao containing the acronychia pedunculata essential oil can effectively seal wound surfaces, stop bleeding and disinfect, prevent wound infection and inflammation, accelerate wound healing and relieve swelling and pain; the preparation method is simple in process, and active ingredients in the medicinal materials can be effectively extracted, so that the efficacy of the medicine is maximized; and the preparation method is suitable for preparing the Jinchuangyao containing the acronychia pedunculata essential oil, and the Jinchuangyao is used for stopping bleeding, relieving pain, and diminishing swelling and inflammation of wounds.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a medicine for golden sores and a preparation method thereof, in particular to a medicine for golden sores containing Jiangzhen essential oil and a preparation method thereof. Background technique [0002] Trauma is the destruction of human tissues or organs caused by mechanical factors. Any external factors imposed on the human body also include structural or functional damage caused by high temperature, cold, electric current, radiation, acid, alkali, poisonous gas, poisonous insects, mosquito bites, etc. Trauma is very common, not only can occur in large numbers in wartime, but also in peacetime, including cuts, stab wounds, contusions, sprains and so on. Due to the rapid development of industry, agriculture, transportation and sports, the trauma caused by various accidents is increasing day by day. Trauma not only has a high incidence rate, but also va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K36/896A61K36/48A61P17/02A61P7/04A61P29/00A61P31/04A61P31/10A61P3/10A61K33/22A61K33/12A61K35/618
CPCA61K36/48A61K33/22A61K33/12A61K36/53A61K36/258A61K36/537A61K35/618A61K36/889A61K36/896A61P17/02A61P7/04A61P29/00A61P31/04A61P31/10A61P3/10A61K2236/37A61K2236/333A61K2236/33A61K2236/35A61K2236/51A61K2300/00
Inventor 刘宏智
Owner 海南长永恒生物科技有限公司
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