Water-soluble ceramide NP composition as well as preparation process and application thereof

A technology of ceramide and composition, applied in the field of water-soluble ceramide NP composition, can solve the problems of poor stability and low solubility of ceramide, and achieve the effects of reducing wrinkles, repairing skin barrier function and inhibiting activity

Pending Publication Date: 2021-11-09
广东格烯生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention solves the problems of low solubility and poor stability of ceramide in the prior art by providing a water-soluble ceramide NP composition, and realizes a

Method used

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  • Water-soluble ceramide NP composition as well as preparation process and application thereof
  • Water-soluble ceramide NP composition as well as preparation process and application thereof
  • Water-soluble ceramide NP composition as well as preparation process and application thereof

Examples

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Embodiment 1

[0042] This embodiment provides a water-soluble ceramide NP composition, the raw materials of which include ceramide, phospholipid, surfactant, hydroxyl-terminated compound, and solvent; the ceramide, phospholipid, surfactant, hydroxyl-terminated compound, The weight ratio of solvents is 2.5:7:0.5:31:59.

[0043] The ceramide is ceramide NP, whose INCI name is CERAMIDE NP, which comes from Evonik, Germany.

[0044] The phospholipid is phosphatidylcholine, whose INCI name is PHOSPHATIDYLCHOLINE, which comes from Sigma-Aldrich Company.

[0045] The surfactant is sodium stearyl glutamate, the INCI name is SODIUM STEAROYLGLUTAMATE, and the CAS number is 38517-23-6.

[0046] The hydroxyl-terminated compounds are 1,3-butanediol and 1,2-hexanediol; the weight ratio of 1,3-butanediol and 1,2-hexanediol is 30:1.

[0047] The solvent is deionized water.

[0048] The preparation process of the water-soluble ceramide NP composition comprises:

[0049] S1. Mixing ceramide NP and phosph...

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Abstract

The invention relates to the field of IPC A61K8/68, in particular to a water-soluble ceramide NP composition as well as a preparation process and application thereof. The water-soluble ceramide NP composition is prepared from the following raw materials: ceramide NP, phospholipid, a surfactant, a hydroxyl-terminated compound and a solvent; and the weight ratio of the ceramide NP to the phospholipid is 1: (2-15). The average particle size of the water-soluble ceramide can be as low as 70 nm, the application problems that ceramide is high in melting point, poor in water solubility and difficult to emulsify are successfully solved, and the application convenience of a ceramide formula is greatly improved. When being applied to cosmetics, the composition can repair barriers, delay senescence and immediately repair the skin barrier function; the water content of the keratoderma can be increased, aged fibroblasts are activated, wrinkles are reduced, and the skin softness is improved; meanwhile, free radicals can be effectively removed, the skin is synergistically whitened, and the skin glossiness is improved.

Description

technical field [0001] The invention relates to the field of IPC A61K8 / 68, in particular to a water-soluble ceramide NP composition and its preparation process and application. Background technique [0002] As an important physiological lipid component, ceramide is very important to maintain the skin barrier function, strengthen the adhesion between keratinocytes, and balance the hydration of the epidermis. As we age, the content of ceramides in the skin decreases, and adding ceramides to cosmetics has become a popular means of improving skin care effects. However, traditional ceramide raw materials are fat-soluble substances, which have extremely low solubility in water and are difficult to be absorbed by the human body. At the same time, after ceramide is directly added to the cosmetic formula, it is easy to crystallize and precipitate during the storage process, reducing the stability of the system. [0003] Chinese patent CN201810215403.6 discloses a ceramide liposome a...

Claims

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Application Information

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IPC IPC(8): A61K8/68A61K8/55A61Q19/00A61Q19/10A61Q19/08A61Q19/02
CPCA61K8/68A61K8/553A61Q19/00A61Q19/10A61Q19/08A61Q19/02A61K2800/262A61K2800/412A61K2800/522
Inventor 沈罟方紫陈晓颖
Owner 广东格烯生物科技股份有限公司
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