I-type collagen production promoter

A technology of collagen and accelerator, which is applied in skin care preparations, cosmetics, medical preparations containing active ingredients, etc. It can solve the problems of large molecular weight of collagen, difficulty in skin barrier absorption, and no effect on improving skin quality.

Pending Publication Date: 2021-11-09
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after collagen is digested by the gastrointestinal tract, it is decomposed into small molecular amino acids and polypeptides by protease, and the shape and structure of collagen no longer exist. Oral collagen has little effect on improving skin quality
2. Collagen smearing: There are many smearing collagen products on the market, such as facial masks, etc., but due to the large molecular weight of collagen, it is diff

Method used

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  • I-type collagen production promoter
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  • I-type collagen production promoter

Examples

Experimental program
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Effect test

preparation example 1

[0035] Preparation Example 1: Preparation of Motherwort (Leonurus japonicus) Extract

[0036] According to the size of the reaction vessel, add 5 to 10 parts by weight of a 1:1 mixture of deionized water and ethanol to 1 part by weight of motherwort powder, and carry out ultrasonic stirring under the condition that the motherwort powder is completely immersed in the solvent, and then mix it at 75-80 °C for heating and extraction for 5-8 hours, and then concentrated and dried to obtain Motherwort extract.

[0037] Add 19 parts by weight of a 6:4 mixture of water and butanediol to 1 part by weight of the motherwort extract obtained above, dissolve it, perform decolorization and deodorization treatment, and leave it at 6-8°C for 48 hours at low temperature after treatment, Remove the insoluble matter by filtration, add preservatives 1,2-hexanediol and p-hydroxyacetophenone, so that their concentration reaches 0.4wt% ~ 0.6wt% respectively, thus obtain the semi-finished product of ...

Embodiment 1

[0038] Example 1. Anti-aging efficacy test experiment of motherwort extract

[0039] (1) Description of the principle of the test method:

[0040] Human type Ⅰ collagen (Col Ⅰ) Collagen test principle: Coat the microwell plate with purified antibody to make a solid phase carrier, add specimen or standard, biotinylated anti ColI antibody, HRP-labeled avidin, after thorough washing, was developed with substrate TMB. TMB is converted into blue under the catalysis of peroxidase, and into the final yellow under the action of acid. The depth of the color is positively correlated with ColI in the sample. Measure the absorbance (OD value) at a wavelength of 450 nm with a microplate reader, and calculate the sample concentration.

[0041] (2) Test drugs, materials, instruments and preparations: fibroblasts (HFF-1); human skin keratinocytes (HaCaT); DMEM medium (GIBCO, 500ml); fetal bovine serum (GIBCO, 500ml); trypsin- EDTA (GIBCO, 100ml); Phosphate Buffer Solution (CORNING, 500ml)...

Embodiment 2

[0054] Example 2. Anti-aging efficacy test experiment of motherwort extract

[0055] (1) Description of the principle of the test method:

[0056] Human type Ⅰ collagen (Col Ⅰ) Collagen test principle: Coat the microwell plate with purified antibody to make a solid phase carrier, add specimen or standard, biotinylated anti ColI antibody, HRP-labeled avidin, after thorough washing, was developed with substrate TMB. TMB is converted into blue under the catalysis of peroxidase, and into the final yellow under the action of acid. The depth of the color is positively correlated with ColI in the sample. Measure the absorbance (OD value) at a wavelength of 450 nm with a microplate reader, and calculate the sample concentration.

[0057](2) Test drugs, materials, instruments and preparations: fibroblasts (HFF-1); human skin keratinocytes (HaCaT); DMEM medium (GIBCO, 500ml); fetal bovine serum (GIBCO, 500ml); trypsin- EDTA (GIBCO, 100ml); Phosphate Buffer Solution (CORNING, 500ml),...

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Abstract

The invention provides an I-type collagen production promoter. The I-type collagen production promoter is characterized in that the I-type collagen production promoter is at least one selected from a leonurus japonicus extract and a polygonatum odoratum extract.

Description

technical field [0001] The present invention relates to novel type I collagen production promoters, the use of these new type I collagen production promoters in cosmetics, and cosmetics containing these new type I collagen production promoters. Background technique [0002] Beauty, beauty and anti-aging are the goals that people have been pursuing, and our company has been committed to finding products with beauty, beauty and anti-aging effects. Collagen present in the dermis is the main factor affecting skin aging. If the collagen content in the dermis is reduced, the skin will show signs of aging, lose its elasticity, gradually loosen, and form wrinkles. If the collagen content in the dermis is rich, the skin will look full of elasticity, young and shiny, so if you can find Products that promote the increase of collagen content in the dermis can realize the dream of beauty and anti-aging. [0003] The methods of supplementing collagen in the prior art include, 1. Eat mor...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9794A61Q19/08
CPCA61K8/9789A61K8/9794A61Q19/08A61K2800/805
Inventor 李念哲
Owner SHISEIDO CO LTD
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