Preparation method of Huangpu Tongqiao granules

A technology of putongqiao and granules, which is applied in the field of medicine, can solve the problems of long duration and shock of patients and family members, and achieve the effect of convenient concentration, reducing the number of times of taking medicine, and rapid action

Pending Publication Date: 2021-11-23
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

AD lasts for a long time in the process of occurrence and development, which brings a painful blow to patients and their families, and further brings a serious burden to the progress and development of society. AD has become a serious social public health problem

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  • Preparation method of Huangpu Tongqiao granules

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preparation example Construction

[0034] Such as figure 1 Shown, the preparation method of a kind of Huangpu Tongqiao granule of the present invention, comprises the steps:

[0035] Accurately weigh 60g of rhubarb, 200g of Shichangpu, 200g of Yizhiren, 200g of Rhizoma Chuanxiong, 60g of Zhishouwu and beat into coarse powder, then add 100g of ginseng and beat into fine powder to obtain Huangpu Tongqiao Fang powder;

[0036] Using CO 2 Extract the active ingredients of Huangpu Tongqiao Formula powder by supercritical extraction method, wherein the extraction temperature is 40-60°C, the extraction pressure is 10-14Mpa, the extraction time is 2-3 hours, CO 2 The flow rate is 20-30kg / h, the entrainer is ethanol, the ratio is 4-6%, and the extract is collected;

[0037] Using the above CO 2 The active ingredients of Huangpu Tongqiao Formula powder were extracted by supercritical extraction method. Compared with the method of water extraction, the main components of Huangpu Tongqiao Formula: stilbene glycoside, fe...

Embodiment 1

[0048] Precisely weigh 60g of rhubarb, 200g of calamus, 200g of Yizhiren, 200g of Rhizoma Chuanxiong, 60g of Radix Polygoni Multiflori, beat into a coarse powder, then add 100g of ginseng to grind fine powder, and obtain Huangpu Tongqiao Fang powder;

[0049] Using CO 2 The active ingredient of Huangpu Tongqiao Fang powder was extracted by supercritical extraction method, the extraction temperature was 40°C, the extraction pressure was 12Mpa, the extraction time was 2.5 hours, CO 2 The flow rate is 25kg / h, the entrainer is ethanol, the ratio is 5%, and the extract is collected; compared with the method of water extraction, the main components of Huangpu Tongqiao Formula: stilbene glycosides, ferulic acid, ginsenoside Rg1, aloe rhubarb The extraction rate of ferulic acid, β-asarone, emodin, and chrysophanol has been significantly increased, among which the extraction rate of ferulic acid has increased by about 10%, and the extraction rate of ginsenoside Rg1 has increased by abo...

Embodiment 2

[0055] Precisely weigh 60g of rhubarb, 200g of calamus, 200g of Yizhiren, 200g of Rhizoma Chuanxiong, 60g of Radix Polygoni Multiflori, beat into a coarse powder, then add 100g of ginseng to grind fine powder, and obtain Huangpu Tongqiao Fang powder;

[0056] Using CO 2 The active ingredient of Huangpu Tongqiao Fang powder was extracted by supercritical extraction method, the extraction temperature was 50°C, the extraction pressure was 13Mpa, the extraction time was 2 hours, CO 2 The flow rate is 20kg / h, the entraining agent is ethanol, the ratio is 4%, and the extract is collected; compared with the method of water extraction, the main components of Huangpu Tongqiao formula: stilbene glycosides, ferulic acid, ginsenoside Rg1, aloe rhubarb The extraction rate of ferulic acid, β-asarone, emodin, and chrysophanol has been significantly increased, among which the extraction rate of ferulic acid has increased by about 9.7%, and the extraction rate of ginsenoside Rg1 has increased ...

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Abstract

The invention discloses a preparation method of Huangpu Tongqiao granules. The preparation method comprises the following steps of grinding six traditional Chinese medicines, namely ginseng, rheum officinale, rhizoma acori graminei, fructus alpiniae oxyphyllae, ligusticum wallichii and radix polygoni multiflori preparata as a prescription into fine powder, so as to obtain Huangpu Tongqiao prescription powder; extracting active ingredients of Huangpu Tongqiao prescription powder by adopting a CO2 supercritical fluid extraction method, and collecting extract liquor; carrying out vacuum concentration, drying and crushing on the extract liquor to obtain dry extract powder with the particle size of less than 50 microns (completely passing through a 300-mesh sieve); and mixing the dry extract powder with pharmaceutic adjuvants to prepare the Huangpu Tongqiao granules. According to the preparation method, main active ingredients are extracted from the Huangpu Tongqiao prescription by adopting a CO2 supercritical extraction separation technology, the Huangpu Tongqiao granules are prepared through the procedures of modern concentration, drying, granulation and the like, compared with a water extraction mode, the extraction rate of the main active ingredients of the Huangpu Tongqiao prescription is greatly increased, and the prepared Huangpu Tongqiao granules have the advantages of good solubility, high forming rate, low hygroscopicity and the like, can be packaged into 20g / bag of Huangpu Tongqiao granules for use, and are easy for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of Huangpu Tongqiao Granules. Background technique [0002] Alzheimer's disease (AD) is the most common type of senile dementia. With the continuous aggravation of population aging process, the incidence of AD has increased sharply, and AD has become one of the major health and socioeconomic problems faced by the world. AD lasts for a long time in the process of occurrence and development, which has brought a painful blow to patients and their families, and further brought a serious burden to the progress and development of society. AD has become a serious social public health problem. [0003] Traditional Chinese medicine believes that the etiology and pathogenesis of Alzheimer's disease are mostly due to the depletion of kidney essence, insufficient qi and blood, and dystrophy of the brain caused by aging, physical weakness, mental disorder, ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/16A61K36/9062A61K47/36A61K47/26A61P25/28
CPCA61K9/1652A61K9/1623A61K36/708A61K36/888A61K36/9062A61K36/236A61K36/704A61K36/258A61P25/28A61K2236/37A61K2236/51A61K2300/00
Inventor蔡标谢道俊陈卫东赵国栋叶树宋航王国权
OwnerANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE