Sampling equipment and filling machine internally provided with sampling equipment

Abstract

The invention relates to sampling equipment and a filling machine internally provided with the sampling equipment. The sampling equipment is arranged at a sampling point in the filling machine and comprises a placement barrel, wherein sampling vessels are vertically stacked in the placement barrel; the sampling vessels are lifted through a lifting plate; in a lifting process, a convex portion on one side of a cover body of each sampling vessel is relatively pressed down, so that the sampling vessels are uncovered and settled bacteria are collected; after the collection is finished, the sampling vessels are pushed by a push rod at the top of the placement barrel; in the process, a stopping rod arranged at the top of the placement barrel is used for stopping, so that the cover bodies of the sampling vessels are buckled and the sampling vessels are pushed into a collection device to be collected; one cycle is finished, and furthermore, the second sampling vessel is lifted and opened to carry out sampling, so that environment monitoring of one batch of filling is finished; and in the process, the sampling vessels are completely and automatically replaced and manual intervention is not needed.

Description

technical field [0001] The invention relates to a filling machine with sampling equipment inside and the sampling equipment, in particular to a sampling equipment for automatically replacing sampling vessels in the aseptic filling machine and an aseptic filling machine using the sampling equipment . Background technique [0002] A filling machine is generally a device with a closed or semi-closed internal space, and a filling device is installed inside the space to fill the drug into the container and press the stopper to complete the filling. In the filling process of a batch of medicines, the internal environment needs to be monitored, and the monitoring methods are generally divided into active sampling and passive sampling. Active sampling uses planktonic sampling equipment, while the monitoring of sedimentation bacteria (passive sampling) is Place the sampling vessel at a designated position inside it. Generally speaking, the sampling vessel needs to be replaced manual...

AI Technical Summary

Problems solved by technology

In the filling process of a batch of medicines, the internal environment needs to be monitored, and the monitoring methods are generally divided into active sampling and passive sampling. Active sampling uses planktonic sampling equipment, while the monitoring of sedimentation bacteria (passive sampling) is Place the sampling container at a designated location inside it. Generally speaking, the sampling container needs to be replaced manually every 2-4 hours. If it is overtime, it will cause the sampling container to lack water and crack, which will affect the monitoring results.

[0003] Taking the aseptic filling machine as an example, due to its ultra-high internal environmental requirements, its interior is a completely enclosed space. When sampling sedimentation bacteria, it is necessary to pass the sampling dishes required for a filling batch through the The window is placed inside it together, and then the operator needs to replace the sampling dish through the thick rubber gloves on the side window of the isolator every 2-4 hours, which is not only inconvenient to operate and easy to make mistakes, but also easy to cause personnel to forget to replace the sampling vessel due to negligence The problem of inaccurate monitoring results caused by the dish, and because multiple monitoring points will be set inside the aseptic filling machine during the filling process, the staff need to frequently change the location and wear different thick rubber gloves, extremely time consuming

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