Application of NMN combined CD38 inhibitor in preparation of medicine for preventing or treating cardiotoxicity caused by adriamycin
A technology of CD38 and cardiotoxicity, applied in the field of biomedicine, can solve the problems of no significant increase in tissue NAD level, low NAD replenishment efficiency, and weakened NAD effect, so as to relieve the limitations of clinical application, increase cardiac NAD content, and weaken DIC. Effect
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[0021] as per figure 1 The technical route shown is to construct an animal model of doxorubicin cardiotoxicity, specifically: inject 5 mg / kg of doxorubicin or normal saline into the tail vein of 8-week-old C57BL / 6 male mice, and the administration frequency is once a week, For four consecutive weeks, the cumulative dose of doxorubicin was 20 mg / kg, and the end point of the DIC model was 4 weeks after the last administration. Drug combination application: NMN was dissolved in saline, and 78c was dissolved in DMSO. Three hours before doxorubicin injection, mice were injected intraperitoneally with 500 mg / kg NMN and 10 mg / kg CD38 inhibitor 78c. The frequency of NMN administration was once every two days and 78c was once a day until the end of the model. After the end of the model, echocardiography was performed on the mice to detect the heart function of the mice, and the myocardial tissue of the mice was taken to detect the NAD content. The results are as follows: figure 2 –4...
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