Preparation method and application of cobalt-doped metal organic framework nanoparticles

Abstract

The invention belongs to the technical field of materials, and relates to a preparation and application of cobalt-doped metal organic framework nanoparticles, and the cobalt-doped metal organic framework nanoparticles have good hydroxyl radical generation capability and good drug loading performance. Doped cobalt metal ions enable the nucleation number in a reaction system to be increased, the concentration of relative ligands is greatly consumed, polyvinylpyrrolidone is used as a stabilizer, the nano-particles are protected and dispersed, the nanoparticles stop growing in a small size, and therefore synthesis of small-size CoZn-MOF-5 materials is achieved. The nanoparticle material is small in size, good in dispersity and high in loading capacity, and can be sensitively controlled to be released under the high glutathione expression acidic tumor cell microenvironment, meanwhile, cobalt ions doped in the material can react with hydrogen peroxide overexpressed by tumor cells to generate hydroxyl free radicals, the coordination of a chemical kinetic therapy and a chemical therapy is realized, and the cobalt-doped metal organic framework nanoparticles are a good nano anti-cancer drug carrier.

Description

Technical field [0001] The present invention belongs to the field of materials technology, and its application relates to the preparation of cobalt metal organic framework doped nanoparticles, particularly one size smaller and has a cobalt doped metal organic framework material, chemical kinetics therapy (properties of CoZn -MOF-5) was prepared. Background technique [0002] Nowadays, cancer has become a global public health problem, with regard to its treatment methods to explore the long-standing concern of governments and researchers. The most common treatment for cancer chemotherapy as effective means, there are still some limitations, anti-cancer drugs themselves generally do not have the recognition of tumor cells, some of the body's immune cells, neutrophils and even killing normal cells also have the ability, the body would the vital organs causing irreparable damage, have greater side effects on the liver and other organs, and therefore suitable pharmaceutical carrier is...

AI Technical Summary

Problems solved by technology

When used, small-sized drug carriers can accumulate in tumor tissues by achieving high permeability and retention effect (EPR effect), so as to realize passive targeting of drugs, reduce toxic side effects, and improve circulation stability. The size of MOF-5 materials is relatively large, mostly at the micron level, which limits the use of MOF-5 as a drug carrier and the preparation of MOF thin films.

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