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Preparation method and application of cobalt-doped metal organic framework nanoparticles

A metal-organic framework and nanoparticle technology, applied in the field of materials, can solve the problems of limitation and large size of materials, and achieve the effects of long duration, small size and easy preparation

Active Publication Date: 2021-12-07
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When used, small-sized drug carriers can accumulate in tumor tissues by achieving high permeability and retention effect (EPR effect), so as to realize passive targeting of drugs, reduce toxic side effects, and improve circulation stability. The size of MOF-5 materials is relatively large, mostly at the micron level, which limits the use of MOF-5 as a drug carrier and the preparation of MOF thin films.

Method used

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  • Preparation method and application of cobalt-doped metal organic framework nanoparticles
  • Preparation method and application of cobalt-doped metal organic framework nanoparticles
  • Preparation method and application of cobalt-doped metal organic framework nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 150mg 2.4mg terephthalic acid and polyvinylpyrrolidone dissolved in 6.4mL volume ratio of 5: 3 mixed solution of DMF and absolute ethanol, sonicated for 10 minutes to dissolve all the solids, placed on a magnetic stirring after agitating for 10 minutes, was added zinc nitrate hexahydrate and cobalt nitrate hexahydrate 11.35mg 11.6mg of a uniformly mixed, stirred until homogeneous clarification, was transferred to a 13mL teflon reaction vessel, placed in a forced air oven capable of 150 ℃ reaction 12h, slowly cooled to room temperature, centrifuged at 11,000 rpm to obtain a precipitate, DMF washing 3 times, washed three times with ethanol, and dried is placed within 24h 60 deg.] C vacuum oven to obtain CoZn-MOF-5 nanoparticles.

[0033] figure 1 Present scanning electron micrographs (SEM) of the product of Example obtained, it can be seen from the figure, to obtain a uniform spherical nanoparticles with dimensions of 60 140nm ~, figure 2 Transmission electron microsco...

Embodiment 2

[0035] Weigh 100mg 1.94mg terephthalic acid and polyvinylpyrrolidone dissolved in 6.4mL volume ratio of 3: a mixed solution of DMF and ethanol 2, sonicated for 10 minutes to dissolve all the solids, placed on a magnetic stirring on stirring for 10 minutes, a mixed after adding zinc nitrate hexahydrate and cobalt nitrate hexahydrate of 12.76mg 10.22mg, and stirred for 20 minutes, transferred to a 13mL teflon reaction vessel, the reaction oven at 120 deg.] C for 20 h, cooled slowly to at room temperature, the product was collected and centrifuged 11000rpm, DMF washing 3 times, washed three times with ethanol, and dried is placed within 24h 100 deg.] C vacuum oven to obtain CoZn-MOF-5 nanoparticles, and still maintain a small size.

Embodiment 3

[0037] Weigh 150mg 2.59mg terephthalic acid and polyvinylpyrrolidone dissolved in 6.4mL volume ratio of 7: 3 mixture of DMF and a solution of anhydrous ethanol, sonicated for 15 minutes to dissolve all the solids, placed on a magnetic stirring was stirred for 15 minutes, a mixed after adding zinc nitrate hexahydrate and cobalt nitrate hexahydrate of 10.44mg 12.48mg, and stirred for 15 minutes, transferred to a 13mL teflon reaction vessel, the reaction oven at 130 ℃ 15H, cooled slowly to at room temperature, the product was collected and centrifuged 11000rpm, DMF washing 3 times, washed three times with ethanol, the 150 deg.] C in a dry 20h vacuum oven to obtain CoZn-MOF-5 nanoparticles, and still maintain a small size.

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Abstract

The invention belongs to the technical field of materials, and relates to a preparation and application of cobalt-doped metal organic framework nanoparticles, and the cobalt-doped metal organic framework nanoparticles have good hydroxyl radical generation capability and good drug loading performance. Doped cobalt metal ions enable the nucleation number in a reaction system to be increased, the concentration of relative ligands is greatly consumed, polyvinylpyrrolidone is used as a stabilizer, the nano-particles are protected and dispersed, the nanoparticles stop growing in a small size, and therefore synthesis of small-size CoZn-MOF-5 materials is achieved. The nanoparticle material is small in size, good in dispersity and high in loading capacity, and can be sensitively controlled to be released under the high glutathione expression acidic tumor cell microenvironment, meanwhile, cobalt ions doped in the material can react with hydrogen peroxide overexpressed by tumor cells to generate hydroxyl free radicals, the coordination of a chemical kinetic therapy and a chemical therapy is realized, and the cobalt-doped metal organic framework nanoparticles are a good nano anti-cancer drug carrier.

Description

Technical field [0001] The present invention belongs to the field of materials technology, and its application relates to the preparation of cobalt metal organic framework doped nanoparticles, particularly one size smaller and has a cobalt doped metal organic framework material, chemical kinetics therapy (properties of CoZn -MOF-5) was prepared. Background technique [0002] Nowadays, cancer has become a global public health problem, with regard to its treatment methods to explore the long-standing concern of governments and researchers. The most common treatment for cancer chemotherapy as effective means, there are still some limitations, anti-cancer drugs themselves generally do not have the recognition of tumor cells, some of the body's immune cells, neutrophils and even killing normal cells also have the ability, the body would the vital organs causing irreparable damage, have greater side effects on the liver and other organs, and therefore suitable pharmaceutical carrier is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K31/704A61K9/52A61P35/00
CPCA61K47/6949A61K31/704A61K9/5026A61K9/5015A61P35/00Y02E60/32
Inventor 谭振权宫艺书宋学志
Owner DALIAN UNIV OF TECH
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