35results about How to "Achieve passive targeting" patented technology

The invention provides thermo-sensitive liposome. The thermo-sensitive liposome comprises a chemotherapeutic drug, a photosensitizer, phosphatidylcholine and polyethylene glycol-derived phospholipid, wherein the photosensitizer is indocyanine green or chlorins e6; the grain size of the thermo-sensitive liposome is 40-60 nm; by virtue of living-body fluorescence imaging, a distribution process of the thermo-sensitive liposome can be observed in real time; under a near-infrared light irradiation condition, the chemotherapeutic drug can be quickly and effectively released, so that the chemotherapeutic drug can be enriched at a target part very well; the obtained thermo-sensitive liposome particle has smaller particle diameter less than 100 nm, and good biocompatibility. The preparation method of the thermo-sensitive liposome is simple and easy to operate.

The invention discloses a tumor-targeted nonionic dendritic macromolecule magnetic resonance imaging contrast agent and a preparation method thereof. The contrast agent is a spherical nano composite particle prepared by taking a PAMAM dendritic macromolecule as a nuclear, folic acid as a targeting group, polyethyleneglycols (PEG) with different molecular weights as linking arms between the targeting group and a macromolecular carrier, and diethylenetriamine pentaacetic acid (DTPA) as a Gd<3+> ligand; and the preparation method comprises the following steps: reacting H2N-PEG-FA with folic acidresidue and diethylenetriamine pentaacetic acid double active ester (SuO-DTPA-SuO) to obtain SuO-DTPA-PEG-FA; and then bonding the SuO-DTPA-PEG-FA on the surface of the PAMAM to obtain PAMAM-DTPA-PEG-FA; and finally chelating the PAMAM-DTPA-PEG-FA and Gd<3+>. The imaging contrast agent prolongs the circulation time in blood, improves the relaxation rate, can be effectively distributed in tumor tissues, reduces the toxicity on normal tissues, and has the advantages of long-acting circulation in vivo, improvement of the relaxation rate, reduction of the medicament consumption and the like.

The invention discloses a medicine carrier based on a nano diamond. The medicine carrier is a nano diamond medicine carrier with doped rare earth elements, namely europium and gadolinium. A preparation method of the medicine carrier comprises the following steps: performing silanization chemical modification on the surface of a nano diamond so as to obtain a surface silanizated nano diamond, namely ND-APTES (Nano Diamond-Aminopropyl Triethoxysilane); performing silanization modification on alpha-thenoyl trifluoroacetone so as to obtain silanizated alpha-thenoyl trifluoroacetone, namely TTA-Si;enabling the surface silanizated nano diamond and silanizated organic ligand to react with Eu<3+> and Gd<+3> in a solvent, thereby obtaining the medicine carrier ND-TTA:RE<+3> based on the nano diamond. The medicine carrier based on the nano diamond, which is disclosed by the invention, is capable of not only carrying doxorubicin hydrochloride, but also carrying other medicines, and is applicableto different diseases, and transmission of different medicines can be achieved.

The invention discloses a zwitter-ion-contained multiple acid-sensitive anti-tumor drug-loading micelle, and a preparation method and an application thereof, and belongs to the field of biological materials. The zwitter-ion-contained multiple acid-sensitive anti-tumor drug-loading micelle comprises a zwitter-ion hydrophilic shell and a lyophobic core containing two acid-sensitive bonds. The method includes the steps: separating methanol from hydroxyethyl acrylate and 2,2-dimethoxypropane and synthesizing 2,2-di(acryloyloxy-1-oxethyl) propane by an alcohol exchange method; connecting open-loop beta-propiolactone with 2-(dimethylamino) ethyl methacrylate to synthesize carboxybetaine methacrylate; obtaining a carboxybetaine methacrylate monomer polymer by an atom transfer free radical polymerization method; synthesizing triblock amphiphilic polymers by the atom transfer free radical polymerization method and a Michael addition one-pot method, and preparing the drug-loading nano-micelle by an ultrasonic drop method and a dialysis method. By aid of the drug-loading micelle, anti-tumor effects of chemotherapeutic drugs can be improved.

The invention discloses a sorafenib medicinal lipid nanosuspension and a preparation method of the sorafenib medicinal lipid nanosuspension. The sorafenib medicinal lipid nanosuspension is prepared by adopting a nanoprecipitation method or / and a high-pressure homogenization method, wherein phospholipids and tween-80 are taken as stabilizers. The prepared sorafenib lipid nanosuspension is good in biocompatibility, high in drug loading capacity, and small in grain diameter; freeze-drying can be realized only by adding a small amount of freeze-drying protective additive; the freeze-dried product is good in reconstruction property; for the prepared sorafenib lipid nanosuspension, the in-vivo tissue distribution of the medicine can be improved, the distribution of the medicine in the liver and tumor can be obviously enhanced, and thus the anti-tumor effect of the sorafenib lipid nanosuspension can be obviously enhanced; the preparation condition is mild, simple and controllable, and thus the development prospect is wide.

The invention provides a preparation method of a double-cell and microenvironment-sensitive anti-tumor drug-loaded nanocapsule. The method comprises the following steps: (1) preparing a thiol hyaluronic acid; (2) preparing vinyl-functional second-generation isopropylidene-protected galactopyranose; (3) grafting the second-generation isopropylidene-protected galactopyranose on the thiol hyaluronic acid; and (4) preparing the drug-loaded nanocapsule. The drug-loaded nanocapsule prepared by the method is high in compatibility with a tumor cell, has dual high-sensitive responsiveness on high-concentration glutathione and acid environment, achieves high-selectivity rapid release in the tumor cell, and is high in anti-tumor efficiency and good in safety.

The invention discloses an irinotecan hydrochloride nanometer fat beam preparation, which comprises an entrapment material, and irinotecan hydrochloride and a water-based solvent for injection, wherein the entrapment material is one or at least two of PLGA-PEG, PGA-PEG, PCL-PEG, PEG-NH2, PEG-COOH, DSPE-PEG, Solutol HS15, and phospholipid. The invention also discloses a preparation method for the irinotecan hydrochloride nanometer fat beam preparation and irinotecan hydrochloride nanometer fat beam powder preparation prepared by the method. The encapsulation efficiency of the irinotecan hydrochloride nanometer fat beam preparation reaches up to 85%, the grain size of the irinotecan hydrochloride nanometer fat beam preparation is about 10nm, and the irinotecan hydrochloride nanometer fat beam preparation can realize passive target to tumors and can increase pharmacological function and reduce the toxic and side effects of the system. The irinotecan hydrochloride nanometer fat beam powder preparation improves the safety and compliance of the irinotecan hydrochloride preparation, lowers the toxicity of the irinotecan hydrochloride, and prolongs the circulation time in the body. The preparation method is simple and feasible, has good repeatability, and is applicable to industrial production.

The invention discloses a preparation method of a polyene-containing taxol nanoparticle mixed micelle preparation and a freeze-drying agent, which prepares docetaxel PLA-PEG nanoparticles or micelle or nanoparticle mixed micelle through a modified solvent evaporation method, takes PLA-PEG copolymer as a carrier, and wraps docetaxel in a PLA hydrophobic core. When in use, the docetaxel PLA-PEG containing long cycle freeze-dried preparation only needs to be added with water and is dissolved, and uniform nanoparticle suspension, micellar solution or mixed micellar nanoparticle suspension can be prepared. The preparation method does not need tween-80 and ethanol solubilization, only takes the biodegradable PLA-PEG as the carrier, and does not contain any surfactant; and compared with the docetaxel injection on sale, the preparation can reduce the toxicity and the adverse reactions of the medicine, and improve the clinical application safety of the medicine.

The invention discloses a targeted ultrasonic phase-change dual-mode imaging nano-contrast agent as well as a preparation method and application thereof. The ultrasonic phase-change dual-mode imaging nano-contrast agent includes a shell and a core wrapped in it, and the core includes Fe 3 O 4 Nanoparticles and liquid PFH (perfluorohexane); the shell membrane includes PLGA and phospholipids.

The invention provides a bionic binary cooperative nano-carrier as well as a preparation method and an application thereof. The bionic binary cooperative nano-carrier comprises an erythrocyte membrane, glucose oxidase, iron-supporting ferritin nano-particles and a photosensitizer, wherein the glucose oxidase and the iron-supporting ferritin nano-particles are coated with the erythrocyte membrane,and the photosensitizer is embedded into the surface of the erythrocyte membrane or entrapped by the erythrocyte membrane. Chain stimulative responsibility coordination of tumor hunger therapy and chemical kinetic therapy is realized, two enzymes are conveyed to a target site of an organism with the carrier on the basis of biocompatibility of the erythrocyte membrane and tumor targeting of targeting molecules, accurate administration is realized by membrane rupture based on 808 nm near-infrared light illumination in the tumors, the problem of drug resistance is solved effectively, furthermore,systemic toxicity caused by drug application is remarkably reduced, and damage to other normal tissue in an in-vivo circulation process is prevented effectively. The invention further provides the preparation method of the bionic binary cooperative nano-carrier. The bionic binary cooperative nano-carrier and the preparation method have good application prospect.