35results about How to "Achieve passive targeting" patented technology

The invention provides thermo-sensitive liposome. The thermo-sensitive liposome comprises a chemotherapeutic drug, a photosensitizer, phosphatidylcholine and polyethylene glycol-derived phospholipid, wherein the photosensitizer is indocyanine green or chlorins e6; the grain size of the thermo-sensitive liposome is 40-60 nm; by virtue of living-body fluorescence imaging, a distribution process of the thermo-sensitive liposome can be observed in real time; under a near-infrared light irradiation condition, the chemotherapeutic drug can be quickly and effectively released, so that the chemotherapeutic drug can be enriched at a target part very well; the obtained thermo-sensitive liposome particle has smaller particle diameter less than 100 nm, and good biocompatibility. The preparation method of the thermo-sensitive liposome is simple and easy to operate.

The invention provides a preparation method of a double-cell and microenvironment-sensitive anti-tumor drug-loaded nanocapsule. The method comprises the following steps: (1) preparing a thiol hyaluronic acid; (2) preparing vinyl-functional second-generation isopropylidene-protected galactopyranose; (3) grafting the second-generation isopropylidene-protected galactopyranose on the thiol hyaluronic acid; and (4) preparing the drug-loaded nanocapsule. The drug-loaded nanocapsule prepared by the method is high in compatibility with a tumor cell, has dual high-sensitive responsiveness on high-concentration glutathione and acid environment, achieves high-selectivity rapid release in the tumor cell, and is high in anti-tumor efficiency and good in safety.

The invention discloses an irinotecan hydrochloride nanometer fat beam preparation, which comprises an entrapment material, and irinotecan hydrochloride and a water-based solvent for injection, wherein the entrapment material is one or at least two of PLGA-PEG, PGA-PEG, PCL-PEG, PEG-NH2, PEG-COOH, DSPE-PEG, Solutol HS15, and phospholipid. The invention also discloses a preparation method for the irinotecan hydrochloride nanometer fat beam preparation and irinotecan hydrochloride nanometer fat beam powder preparation prepared by the method. The encapsulation efficiency of the irinotecan hydrochloride nanometer fat beam preparation reaches up to 85%, the grain size of the irinotecan hydrochloride nanometer fat beam preparation is about 10nm, and the irinotecan hydrochloride nanometer fat beam preparation can realize passive target to tumors and can increase pharmacological function and reduce the toxic and side effects of the system. The irinotecan hydrochloride nanometer fat beam powder preparation improves the safety and compliance of the irinotecan hydrochloride preparation, lowers the toxicity of the irinotecan hydrochloride, and prolongs the circulation time in the body. The preparation method is simple and feasible, has good repeatability, and is applicable to industrial production.

The invention provides a bionic binary cooperative nano-carrier as well as a preparation method and an application thereof. The bionic binary cooperative nano-carrier comprises an erythrocyte membrane, glucose oxidase, iron-supporting ferritin nano-particles and a photosensitizer, wherein the glucose oxidase and the iron-supporting ferritin nano-particles are coated with the erythrocyte membrane,and the photosensitizer is embedded into the surface of the erythrocyte membrane or entrapped by the erythrocyte membrane. Chain stimulative responsibility coordination of tumor hunger therapy and chemical kinetic therapy is realized, two enzymes are conveyed to a target site of an organism with the carrier on the basis of biocompatibility of the erythrocyte membrane and tumor targeting of targeting molecules, accurate administration is realized by membrane rupture based on 808 nm near-infrared light illumination in the tumors, the problem of drug resistance is solved effectively, furthermore,systemic toxicity caused by drug application is remarkably reduced, and damage to other normal tissue in an in-vivo circulation process is prevented effectively. The invention further provides the preparation method of the bionic binary cooperative nano-carrier. The bionic binary cooperative nano-carrier and the preparation method have good application prospect.