Nanodiamond-based drug carrier, drug complex, preparation method and application thereof

A nano-diamond and composite technology, applied in the field of nano-materials and nano-medicine, can solve biological toxicity and other problems, achieve the effects of reducing toxic side effects, prolonging circulation time, and reducing drug resistance

Active Publication Date: 2020-01-07
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there have been many reports on the research and related technologies of nanomaterials as drug delivery carriers, such as carbon nanotubes, graphene, silicon dioxide, etc., and the experimental results have initially shown that they have a certain role in improving drug efficacy, but It may be biologically toxic

Method used

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  • Nanodiamond-based drug carrier, drug complex, preparation method and application thereof
  • Nanodiamond-based drug carrier, drug complex, preparation method and application thereof
  • Nanodiamond-based drug carrier, drug complex, preparation method and application thereof

Examples

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preparation example Construction

[0054] The preparation method of the above-mentioned nanodiamond-based drug carrier comprises the following steps:

[0055] (1) The silanization chemical modification of the surface of nano-diamond, obtains the nano-diamond of surface silanization, namely ND-APTES; specifically:

[0056] ① Disperse the nano-diamonds in a ceramic crucible, then place them in a muffle furnace at 425-450°C for 5-8 hours and then anneal for 5-8 hours; the nano-diamonds should be evenly spread on the bottom of the magnetic boat.

[0057] ②Mix the annealed nano-diamond with the mixed solution of concentrated sulfuric acid and concentrated nitric acid and then oscillate ultrasonically for 60 minutes, and the ultrasonic power in the ultrasonic pool is 200W;

[0058] ③Put the mixture obtained in step ② into a magnetic stirrer at a stirring rate of 400-700rpm, install a reflux device, stir, heat and reflux at a temperature of 80-90°C, and after reflux for 24-48h, take out the reaction solution and centr...

Embodiment 1

[0081] The preparation method of the drug carrier based on nanodiamond, comprises the following steps:

[0082] (1) The silanization chemical modification of the surface of nano-diamond, obtains the nano-diamond of surface silanization, namely ND-APTES; specifically:

[0083] ① Disperse nano-diamonds in a ceramic crucible, then place them in a muffle furnace at 425°C and anneal for 5 hours; the nano-diamonds should be evenly spread on the bottom of the magnetic boat.

[0084] ②Mix the annealed nano-diamond with the mixed solution of concentrated sulfuric acid and concentrated nitric acid and then oscillate ultrasonically for 60 minutes, and the ultrasonic power in the ultrasonic pool is 200W;

[0085] ③Put the mixture obtained in step ② into a magnetic stirrer at a stirring rate of 400rpm, install a reflux device, stir, heat to reflux at a temperature of 80°C, and after reflux for 24 hours, take out the reaction solution and centrifuge at a speed of 7500rpm for 5 minutes;

[...

Embodiment 7

[0106] The method for preparing a drug complex using the above-mentioned drug carrier based on nanodiamonds, the specific steps are: dissolving the drug carrier based on nanodiamonds in deionized water and ultrasonically oscillating for 10 minutes, with an ultrasonic oscillation power of 800W, mixing doxorubicin hydrochloride with the above solution Stir, the temperature is 35°C, the time is 24h, the mass ratio of the drug to the nanodiamond-based drug carrier is 1:10, after the reaction, the solution is centrifuged at 8000rpm for 5min, and the solid precipitate is taken for drying. Get the drug complex and keep it sealed and protected from light.

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Abstract

The invention discloses a medicine carrier based on a nano diamond. The medicine carrier is a nano diamond medicine carrier with doped rare earth elements, namely europium and gadolinium. A preparation method of the medicine carrier comprises the following steps: performing silanization chemical modification on the surface of a nano diamond so as to obtain a surface silanizated nano diamond, namely ND-APTES (Nano Diamond-Aminopropyl Triethoxysilane); performing silanization modification on alpha-thenoyl trifluoroacetone so as to obtain silanizated alpha-thenoyl trifluoroacetone, namely TTA-Si;enabling the surface silanizated nano diamond and silanizated organic ligand to react with Eu<3+> and Gd<+3> in a solvent, thereby obtaining the medicine carrier ND-TTA:RE<+3> based on the nano diamond. The medicine carrier based on the nano diamond, which is disclosed by the invention, is capable of not only carrying doxorubicin hydrochloride, but also carrying other medicines, and is applicableto different diseases, and transmission of different medicines can be achieved.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials and nanomedicine, and specifically relates to a nanodiamond-based drug carrier, a drug complex, and a preparation method and application thereof. Background technique [0002] Nanomaterials refer to materials with a size ranging from 1-100nm, and their nanoscale size characteristics have attracted extensive attention in the field of nanomedicine. Traditional anticancer drugs, such as doxorubicin, cisplatin, paclitaxel, etc., can effectively inhibit the growth and reproduction of cancer cells. And because the drug molecules are not targeted, the way of administering the drug directly into the patient's body in clinical treatment will not only kill the cancer cells, but also damage the normal tissues and organs of the human body. These problems can be effectively solved by using nanomaterials as drug delivery carriers, loading them with drugs and targeting them to the lesion site. At present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/24A61K31/704A61P35/00A61K49/00A61K49/10
CPCA61K9/145A61K31/704A61K49/0019A61K49/106
Inventor 赵琪秦世荣张东雪单崇新
Owner ZHENGZHOU UNIV
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