Programmed multi-targeting dendrimer assembly drug delivery system and its preparation method and application

A technology of dendritic macromolecules and delivery systems, which is applied in the field of biomedical materials and can solve the problems that the nano-delivery system has not been properly solved.
CN104906076BInactive Publication Date: 2017-11-03SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2017-11-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a programmed multi-target dendrimer assembly drug delivery system, a preparation method and application thereof, and belongs to the field of biomedical materials. The drug delivery system of the present invention uses the amphiphilic dendrimer assembly as the carrier, realizes programmed multiple targeting by responding to the tumor microenvironment, thereby overcoming the main biological obstacles encountered by the drug carrier in the process of transporting the drug in vivo and finally The drug is delivered to its destination. The resulting self-assembled body has programmed multiple targeting effects through various terminal functionalizations. On the one hand, the advantages of good stability, high mechanical strength, multivalent end groups, high branched structure and virus-like intracellular delivery of dendrimers as drug carriers are used; on the other hand, multiple synergistic The self-assembly strategy integrates the advantages of each functional group on the self-assembly motif of dendrimers to facilitate the multi-functionalization of the assembly and the efficient delivery of drug systems. Especially suitable for the delivery of antitumor drugs.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, in particular to a programmed multi-target drug carrier. technical background

[0002] At present, malignant tumors are a serious threat to human health and development, and are one of the common problems faced by all mankind. Chemotherapy, as one of the most commonly used treatment methods, has achieved a certain degree of tumor inhibition; however, current chemotherapy drugs face problems such as poor water solubility, unsatisfactory metabolism and distribution in the body, and large toxic and side effects that need to be resolved urgently. Nano-delivery systems have significant advantages in increasing drug solubility, improving drug metabolism, and reducing side effects. After research and development in recent years, some nano-drug delivery systems have been successfully used in clinical treatment (such as nano-liposomes loaded with doxorubicin Doxil ® , Nanomicelle Genexol-PM loaded wi...

Claims

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