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Trachelospermum jasminoides (Lindl.) Lem. characteristic chromatogram, construction method and quality control method thereof, Trachelospermum jasminoides (Lindl.) Lem. formula granules and preparation method thereof

A technology of characteristic map and construction method, which is applied in the field of stromatoglyceride formula granules and its preparation, can solve problems such as inability to fully control the quality of striatoglyceride formula granules, long time consumption of striatoglycerides, and unstable test results of striatoglycerides, etc. To achieve the effect of ensuring safety and effectiveness, good reproducibility, and good peak shape

Pending Publication Date: 2021-12-07
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Therefore, the technical problem to be solved by the present invention is to overcome the time-consuming quality control of tracholithiasis in the prior art, the unstable test results of tracholithiasis from different origins, and the inability to comprehensively control the quality of tracholithiasis formula granules, etc., thereby providing a Species characteristic map of genus genus genus and its construction method and quality control method, granules of genus genus and its preparation method

Method used

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  • Trachelospermum jasminoides (Lindl.) Lem. characteristic chromatogram, construction method and quality control method thereof, Trachelospermum jasminoides (Lindl.) Lem. formula granules and preparation method thereof
  • Trachelospermum jasminoides (Lindl.) Lem. characteristic chromatogram, construction method and quality control method thereof, Trachelospermum jasminoides (Lindl.) Lem. formula granules and preparation method thereof
  • Trachelospermum jasminoides (Lindl.) Lem. characteristic chromatogram, construction method and quality control method thereof, Trachelospermum jasminoides (Lindl.) Lem. formula granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The present embodiment provides a method for constructing the characteristic map of the decoction pieces of the genus Rhododendron, comprising the following steps,

[0068] Preparation of the test solution: Take about 2 g of the powder of this product (passed through a No. 3 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add 50 ml of water accurately, weigh it, and heat to reflux for 1 hour (heating temperature is 100 °C ), let it cool, weigh again, make up the lost weight with water, shake well, filter, and get the filtrate to obtain the test solution.

[0069] Preparation of the reference solution: take 2.0 g of the reference medicinal material of terrazzo, accurately weighed, put in a stoppered Erlenmeyer flask, accurately add 25 ml of water, heat to reflux for 1.5 h, filter, and take the filtrate to obtain the reference solution of the reference medicinal material.

[0070] Preparation of the reference substance solution: take an appropriate am...

Embodiment 2

[0073] This embodiment provides a method for constructing the characteristic map of the standard decoction freeze-dried powder of Luoshiteng, comprising the following steps,

[0074] The preparation of standard decoction freeze-dried powder: take 17 batches of decoction pieces of terrazzo vine, take 100g each, put them in a casserole, soak for 30 minutes, add 15 times the amount of water for decoction once decocting, boil with strong fire, decoct for 30 minutes with slow fire, filter while hot, and quickly Cool and set aside; add 12 times the amount of decoction pieces to the second decoction, boil with strong fire, decoct with slow fire for 20 minutes, filter while it is hot, cool quickly, set aside, combine the filtrate, concentrate at 50°C until the ratio of solid to liquid is about 1:1, and the relative density 1.05 (45°C), freeze-drying (freeze-drying steps are 3h at -50°C; 1h at -40°C; 1h at -30°C; 2h at -20°C; 2h at -10°C 1h at -5°C; 2h at -5°C; 2h at 0°C; 2h at 10°C; 2...

Embodiment 3

[0090] The present embodiment provides a method for constructing the characteristic map of the formula granules of the syringa vine, comprising the following steps,

[0091] The preparation of need testing solution: get the formula granule (Beijing Kangrentang Pharmaceutical Co., Ltd.) of terrazzo, ground into fine, about 0.3g, accurately weighed, put in a stoppered Erlenmeyer flask, accurately add 25ml of 50% methanol, weighed Determine the weight, sonicate for 60min (250W, 40kHz), let cool, weigh again, make up the lost weight with 50% methanol, shake well, filter, take the subsequent filtrate to obtain the test solution.

[0092] Preparation of the reference solution: take 2.0 g of the reference medicinal material of terrazzo, accurately weighed, put in a stoppered Erlenmeyer flask, accurately add 25 ml of water, heat to reflux for 1.5 h, filter, and take the filtrate to obtain the reference solution of the reference medicinal material.

[0093] Preparation of the reference...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a Trachelospermum jasminoides (Lindl.) Lem. characteristic chromatogram, a construction method and a quality control method thereof, Trachelospermum jasminoides (Lindl.) Lem. formula granules and a preparation method thereof. The method comprises the following steps: (1) preparing a Trachelospermum jasminoides (Lindl.) Lem. test solution; (2) adopting an ultra-high performance liquid chromatography method for detection under a specific gradient elution procedure. The obtained Trachelospermum jasminoides (Lindl.) Lem. characteristic chromatogram has high specificity and good reproducibility, the quality control of Trachelospermum jasminoides (Lindl.) Lem. can be conveniently realized, the construction method is short in time, and the separation degree and the peak shape of each characteristic peak in the obtained characteristic chromatogram are good; besides, the construction method can better extract the effective components such as nortracheloside, tracheloside and trachelogenin in Trachelospermum jasminoides (Lindl.) Lem., so that the quality of Trachelospermum jasminoides (Lindl.) Lem. is controlled, and the safety and effectiveness of Trachelospermum jasminoides (Lindl.) Lem. are ensured.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to a characteristic map of terrazzo vine, a construction method and a quality control method thereof, granules of terrazzo vine formula and a preparation method thereof. Background technique [0002] Trachelospermum jasminoides (Lindl.) Lem.'s dry canes with leaves are processed and processed according to the main quality indicators of standard decoctions; Bitter and astringent, mainly used for dispelling wind and dredging collaterals, cooling blood and reducing swelling, used for rheumatism-heat arthralgia, spasm of tendons, soreness of waist and knees, sore throat, carbuncle, and injury from falls. It is a traditional Chinese medicine commonly used in my country. [0003] According to the "Technical Requirements for Quality Control and Standard Formulation of Traditional Chinese Medicine Formula Granules (Draft for Comment)", Chinese...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/54G01N30/74
CPCG01N30/02G01N30/06G01N30/54G01N30/74Y02A50/30
Inventor 张志强吉艳慧史国华付静安琪
Owner BEIJING KANGRENTANG PHARMA
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