Application of L-glutamine in treatment of osteoarthritis

A technique for glutamine and osteoarthritis, applied in the application field of L-glutamine in the treatment of osteoarthritis, can solve the problems of inaccurate clinical efficacy and high price, and achieve the promotion of extracellular matrix secretion and cartilage repair , reduce inflammatory damage, relieve pain

Pending Publication Date: 2021-12-10
THE SECOND AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its representative drugs include strontium ranelate, hydroxychloroquine, and tumor necrosis factor alpha blockers, etc., but these drugs are basically in the preclinical research stage, and their clinical efficacy is still uncertain and expensive

Method used

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  • Application of L-glutamine in treatment of osteoarthritis
  • Application of L-glutamine in treatment of osteoarthritis
  • Application of L-glutamine in treatment of osteoarthritis

Examples

Experimental program
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Embodiment

[0020] Example: Application of L-glutamine in the treatment of osteoarthritis.

[0021] L-glutamine (L-glutamine, L-Gln) (trade name xinmaglin), the molecular formula is C5H10N2O3, it is a non-essential amino acid mainly concentrated in plasma and skeletal muscle, and plays an important role in human metabolism important regulatory role. Its structural formula is as follows:

[0022]

[0023] (1) Pre-clinical observation results

[0024] To observe the knee joint pain and joint function of 40 patients with chronic gastritis combined with knee joint OA after oral administration of L-Gln for 6 months, using visual analogue scale (Visual Analogue Scale, VAS) and knee joint scoring method ( Keen Society Score (KSS) assessed the pain and joint function scores of the patients at rest and during activities, and found that after oral administration of L-Gln, the patient's knee pain symptoms were significantly relieved, and the joint function was also improved. The results are sho...

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Abstract

The invention discloses application of L-glutamine in treatment of osteoarthritis, and relates to the field of biomedicine. The L-Gln is used for treating a rat OA animal model, and the direct curative effect of the L-Gln on OA is systematically evaluated from the aspects of inflammatory response, extracellular matrix secretion, chondrocyte survival, cartilage regeneration and the like. According to the present invention, the L-Gln is used as an anti-osteoarthritis drug, NKILA gene silencing, TGF-beta receptor blocker and other methods are combined to verify that L-Gln can up-regulate NKILA expression through a TGF-beta 1 pathway so as to inhibit NF-kappa B activation, reduce chondrocyte inflammatory injury and promote extracellular matrix secretion and cartilage repair, the L-Gln can be used as a new, cheap and effective osteoarthritis disease improvement drug, pain caused by diseases of patients can be relieved, the damaged cartilage structure is fundamentally improved, and therefore the progress of the diseases is delayed.

Description

technical field [0001] The invention relates to the field of biomedicine, more specifically, it relates to the application of L-glutamine in the treatment of osteoarthritis. Background technique [0002] Osteoarthritis (OA) is the most common joint disease. It is the degeneration of articular cartilage caused by many factors such as strain, trauma, aging, congenital abnormalities of joints, and joint deformities. It is mainly characterized by the destruction of articular cartilage. Including synovial and chondrocyte inflammation, osteophyte formation and subchondral bone sclerosis and other pathological changes; the clinical manifestations are slowly developing joint pain, stiffness, joint swelling, limited mobility and joint deformity. Approximately 10%-20% of adults suffer from OA, thus imposing a huge socioeconomic burden. [0003] Early osteoarthritis treatment methods are divided into non-drug treatment and drug treatment. Non-drug treatment includes weight loss, aero...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P19/02A61P29/00
CPCA61K31/198A61P19/02A61P29/00
Inventor程文丹马潇
OwnerTHE SECOND AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV