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Novel pathological marker and uses thereof

A non-alcoholic, patient technology for use in diagnosing or monitoring the progression of non-alcoholic hepatic steatosis NAFLD and/or NASH, in the field of devices capable of implementing said method

Pending Publication Date: 2021-12-10
메타데크리미티드
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Problems solved by technology

Fatal bleeding after liver biopsy has a mortality rate of 0.13% to 0.33%, but may be higher in subjects with altered coagulation

Method used

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  • Novel pathological marker and uses thereof
  • Novel pathological marker and uses thereof
  • Novel pathological marker and uses thereof

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Experimental program
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Embodiment

[0371] method

[0372] Nineteen obese male and female subjects with NAFLD (10 females and 9 males, mean age 38.5±1.9 years, BMI 36.79±4.43 kg / m 2 ) were admitted and underwent bariatric surgery. After fasting for 12 hours at night at the time of enrollment, peripheral venous blood was collected and added with EDTA. Patients signed informed consent for the study and surgical intervention.

[0373] Past medical records of all subjects were collected. Objective examinations including height, weight, and anthropometric measurements were also performed. Body mass index (BMI) is weight (kg) divided by height (m 2 )computational. A detailed list of medications used was collected.

[0374] Exclusion criteria were: (1) regular and / or excessive alcohol consumption (>20g alcohol / day for women, >30g alcohol / day for men); (2) secondary to iatrogenic gastrointestinal or immunodeficiency (HIV infection) diseases Clinical evidence of NAFLD; (3) clinical evidence of non-NAFLD liver dise...

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Abstract

The present invention relates to the identification of a novel pathological marker, novel methods for the diagnosis or for the monitoring of the progress of non-alcoholic hepatic steatosis (NAFLD) by the detection and the quantitation of said marker, and devices enabling the implementation of said methods.

Description

technical field [0001] The present invention relates to the identification of new pathological markers, new methods for diagnosing or monitoring the progression of non-alcoholic hepatic steatosis NAFLD and / or NASH by detection and quantification (quantification) of said markers, and the ability to implement said methods device of. Background technique [0002] Non-alcoholic hepatic steatosis, also denoted by the acronym NAFLD (Non-Alcoholic Fatty Liver Disease), presents as a series of histological changes in the liver characterized by the absence of secondary causes of heavy alcohol consumption and liver disease Excessive accumulation of fat within hepatocytes (steatosis, including >5% cellular triglyceride accumulation). [0003] NAFLD is currently the leading cause of altered hepatolytic markers in adults in the Western world and, worryingly, in children and adolescents as well. Updated data reported in Bugianesi and Marietti 2016 (RecentiProg Med 2016;107:360-368) s...

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/085G01N2800/52G01N33/582C12Q1/6883C12Q2563/107
Inventor 莉迪亚·卡斯塔涅托·吉西格特鲁德·明格隆
Owner 메타데크리미티드
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