Hemodialysis filter

A hemodialysis and filter technology, used in dialysis systems, suction devices, semi-permeable membrane separation, etc., can solve the problems of weak removal of protein-bound toxins, inability to remove protein-bound toxins and medium and macromolecular toxins, and improve the removal of toxins. Performance, simple structure, sufficient effect of solute exchange

Pending Publication Date: 2022-01-07
SHINVA MEDICAL INSTR CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0003] Hemodialysis (HD): Using the principles of diffusion and ultrafiltration, the patient's blood and dialysate are simultaneously introduced into the hemodialysis filter. The blood and dialysate flow in opposite directions on the inside and outside of the dialysis membrane. The solute concentration gradient, dialysis gradient and water pressure gradient on the side can achieve concentration balance on both sides through diffusion to remove metabolic waste in the human body. At the same time, it can supplement the required substances and correct electrolyte and acid-base balance disorders, but cannot remove protein-bound toxins. and macromolecular toxins
[0004] Hemofiltration (HF): A method of blood purification that imitates the filtration function of the human glomerulus and uses pressure gradients to excrete harmful substances in the blood through the semi-permeable membrane of the filter. Hemofiltration can remove liver and kidney Small and medium molecular toxins produced by depletion, but clearance of protein-bound toxins is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] preparation figure 1 The film area is 1.5m 2 EXCLEAR 500 hemodialysis filter, polycarbonate housing is provided with a fiber membrane bundle; the number of membrane filaments in the fiber membrane beam is 10,200, the inner diameter is 200 ± 10 μm, wall thickness 30 ± 5 μm; filling yarn is a polyethylene terephthalate polyester yarn, the content is about 33%; the polyether sulfone is asymmetric hollow fiber membrane exists in length of 1 to 5 mm, preferably in the long axis direction. There is a rotation of 5 ° ~ 30 °. The two ends of the polycarbonate housing are provided with a polycarbonate end cap, which is sealed between the polycarbonate housings and the liquid silica gel O-seal and the liquid silicone O-containing seal; the end cap is provided with blood imports and Export; the polycarbonate housing side surfaces are provided with dialysate inlets and dialysate outlets in the longitudinal direction, respectively, which is a Ruhl taper lock joint structure for connecti...

Embodiment 2

[0048] preparation figure 1 The surface area is 1.8m 2 EXCLEAR 800 hemodialysis filter, blood dialysis filter medium polyether sulfone asymmetric hollow fiber membrane is 11800, an inner diameter of 200 ± 10 μm, wall thickness 30 ± 5 μm; filling yarn is poly Prethylene terephthalate polyester yarn, the content of approximately 33%, and the same as in Example 1.

[0049] It also refers to the detection of urea, creatinine, phosphate, vitamin B12 and β2-microglobulin, and detection of blood chamber pressure drop. Among them, according to YY 0053-2016 "Hemodialysis and related treatment of hemodialysis, hemodialysis filter, blood filter and blood concentrator", dialysis liquid flow speed 500 ml / min, blood flow rate 200 ~ 400 mL / min, When the ultrafiltration volume is 0 to 100 mL / min, urea, creatinine, phosphate and vitamin B12 clearance are 196 to 335 mL / min, 186 ~ 310 mL / min, 186 ~ 316 mL / min, and 143 to 239 ml / min. The dialysis liquid flow rate is 800 ml / min, the bl...

Embodiment 3

[0056] preparation figure 1 The surface area is 2.1m 2Excear 1200 hemodialysis filter. The number of membrane filaments of the polyether sulfone in hemarylated filter is 14,000, and the inner diameter is 200 ± 10 μm, the wall thickness is 30 ± 5 μm; the filler yarn is polyethylene terephthalate polyester yarn, The content is about 33%, and the other is the same as in Example 1. It also refers to the detection of urea, creatinine, phosphate, vitamin B12 and β2-microglobulin, and detection of blood chamber pressure drop. Among them, according to YY 0053-2016 "Hemodialysis and related treatment of hemodialysis, hemodialysis filter, blood filter and blood concentrator", dialysis liquid flow speed 500 ml / min, blood flow rate 200 ~ 400 mL / min, When the ultrafiltration volume is 0 ~ 100 mL / min, urea, creatinine, phosphate and vitamin B12 clearance are 199 ~ 359 mL / min, 190 ~ 348 mL / min, 191 to 320 mL / min, and 148 ~ 245 ml / min. The dialysis liquid flow rate is 800 ml / min, ...

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Abstract

The invention provides a hemodialysis filter, which comprises a shell, wherein a fiber membrane bundle is arranged in the shell, and comprises a polyethersulfone asymmetric hollow fiber membrane bundle and filling yarns arranged in the polyethersulfone asymmetric hollow fiber membrane bundle. Compared with the prior art, the hemodialysis filter of the invention has the following characteristics that filling yarns are arranged in a fiber membrane bundle, so that the overlapping opportunity of membranes is reduced, reasonable gaps are kept, dialysate flows and is distributed more uniformly, the effective area of the dialysis membrane is fully exerted, solute exchange is more sufficient, the cleaning performance of the hollow fiber hemodialyzer is improved, and the hemodialysis filter filter has the advantages of a dialyzer and a filter, has the advantages of simple structure, good biocompatibility, high filtration rate, stable physical and chemical properties and the like, and can be popularized and used in the field of blood purification.

Description

Technical field [0001] The present invention belongs to the technical field of medical devices, and in particular, the present invention relates to a blood dialysis filter. Background technique [0002] Blood purification refers to the use of a certain instrument and equipment, and the patient's blood is introduced, and some metabolic waste or toxic substances in the body will be removed, and the blood is brought into the body, the main blood purification method mainly has the following. [0003] Hemodialysis (HD): Use diffusion and ultrafiltration principle to simultaneously introduce blood dialysis filters, blood and dialysate in the dialysis film, the outer side is reverse flow, and the inside and outside of the film The solute concentration gradient, dialysis gradient, and water pressure gradient, through the dispersion, to remove the concentration of concentrations in the human body, and can supplement the required substances, correct electrolytes and acid-base balance disor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D71/68A61M1/16
CPCB01D69/08B01D71/68A61M1/1621A61M1/1623
Inventor 周翠平王晓东韩科学刁秀坤胡春慧
Owner SHINVA MEDICAL INSTR CO LTD
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