Unlock instant, AI-driven research and patent intelligence for your innovation.

Microneedle array having uneven needle density

A microneedle array and microneedle technology, which is applied in the direction of microneedles, needles, and medical devices, can solve the problems of poor skin penetration and achieve the effects of increasing drug content, reliable drug delivery, and reliable delivery

Pending Publication Date: 2022-01-14
COSMED PHARMA
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] It is also described that the needle density of the microneedles and the skin penetration of the needles are 900 microneedles / cm 2 compared to microneedle arrays with 400 needles / cm 2 The microneedle array of needles has poorer skin penetration (Non-Patent Document 2)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microneedle array having uneven needle density
  • Microneedle array having uneven needle density
  • Microneedle array having uneven needle density

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] The mold was set in an injection molding machine (FANUC Corporation), and polyglycolic acid was melted and injection-molded. Carry out injection molding under the conditions of 235°C of barrel temperature, 1350kPa of injection pressure, and 120°C of mold temperature, and the microneedle array of milky white diameter 10mm is taken out ( image 3 ). will zoom in on the Figure 4 shown in .

[0115] The needle density differs between the central portion and the peripheral portion of the substrate. The needle density of the circular part with a diameter of about 5mm in the center is 750 needles / cm 2 , with a total of 169 2-stage microneedles. The needle density of the peripheral part (the part from 5mm to the outer diameter (10mm) from the center) is 960 needles / cm 2 , with a total of 576 2-stage microneedles. A microscope photograph showing the shape of the needle is placed in the Figure 5 shown in . It is a 2-stage needle with a tip length of 30 μm.

[0116] Inst...

Embodiment 2、3、4、 comparative example 3、4

[0125] The mold was mounted on an injection molding machine (FANUC Corporation), and polyglycolic acid was melted and injected. Injection molding was carried out under the conditions of cylinder temperature 235°C, injection pressure 1350kPa, and mold temperature 120°C, and four milky white microneedle arrays with a diameter of 10mm were manufactured. The total length of the needles was 600 μm. The magnified microscope photographs were placed in the Figure 7A and Figure 7B shown in .

[0126] No.1 is a microneedle array in which the needle interval is 650 μm and the needles are uniformly arranged as a whole (Comparative Example 3, Figure 7A ). No.2 is a microneedle array with a needle interval of 400 μm and needles concentrated on the periphery (Example 2, Figure 7B ). The number of needles of No.1 and No.2 is unified to 193.

[0127] No. 3 is a microneedle array in which the needle interval is 400 μm and the needles are uniformly arranged as a whole (Comparative Exa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
areaaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The present invention solves the problem in which microneedles positioned at the central section of the microneedle array are not easily inserted into the skin. This microneedle array is characterized by comprising a substrate and a plurality of microneedles disposed vertically and horizontally on one surface of the substrate, wherein the inter-needle gaps and the needle density of the microneedles are different in the peripheral section and the central section of the substrate. The needle density of the microneedles is preferably sparse in the central section compared to that in the peripheral section of the substrate, and the inter-needle gaps of the microneedles are preferably greater in the central section than those in the peripheral section of the substrate.

Description

technical field [0001] The present invention relates to the technology of microneedle arrays with non-uniform needle density. Background technique [0002] Oral administration and transdermal administration are often used as methods for administering drugs into the human body. Injection is typically a transdermal method of administration. However, injections must be performed by specialists such as doctors and nurses, and are accompanied by pain, which should not be popular with many people. In contrast, recently, a painless transdermal drug delivery method using a microneedle array has attracted attention (Non-Patent Document 1). [0003] When a drug is administered transdermally, the stratum corneum of the skin functions as a barrier for the drug to permeate, and the mere coating of the drug on the skin surface may not necessarily result in sufficient permeability. On the other hand, by perforating the stratum corneum using microscopic needles, that is, microneedles, dr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053A61M2205/0244
Inventor 权英淑李英哲山下裕史梶山健次神山文男
Owner COSMED PHARMA