Subunit vaccine composition against African swine fever as well as preparation method and application thereof

A vaccine composition, African swine fever virus technology, applied in biochemical equipment and methods, vaccines, veterinary vaccines, etc., can solve the problems of virus mutation, immune interference, hidden dangers of biological safety, etc. Immune interference, good safety effect
CN113940992AActive Publication Date: 2022-01-18NOVO BIOTECH CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NOVO BIOTECH CORP
Publication Date
2022-01-18

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Abstract

The invention discloses a subunit vaccine composition against African swine fever as well as a preparation method and an application thereof, and belongs to the technical field of animal vaccines and veterinary biological products. The vaccine comprises an African swine fever outer envelope CD2V protein, an African swine fever outer capsid p72 protein and a pharmaceutically acceptable adjuvant. The preparation method of the vaccine comprises the following steps: 1) preparing African swine fever outer envelope CD2V protein and African swine fever outer capsid p72 protein; 2) mixing the African swine fever outer envelope CD2V protein prepared and the African swine fever outer capsid p72 protein prepared in the step 1) to prepare an antigen solution; and 3) mixing the antigen solution and ISA 201 VG in volume ratio of 46: 54 for emulsification. The vaccine has the advantages of high immunogenicity, good safety and no immune interference. The vaccine can effectively prevent and protect pigs from being infected by African swine fever.
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Description

technical field

[0001] The invention relates to an African swine fever subunit vaccine composition and a preparation method and application thereof, belonging to the technical field of animal vaccines and veterinary biological products. Background technique

[0002] African swine fever (African swine fever, ASF) is an acute, febrile, highly contagious infectious disease of pigs caused by African swine fever virus (ASFV). Pigs infected with African swine fever virus are clinically characterized by skin congestion, internal organ bleeding, and high fever, and the morbidity and mortality are as high as 100%. The disease has been listed as a Class A disease by the World Organization for Animal Health. my country is a large livestock and poultry breeding country, with hog breeding accounting for 56.6% of the world's total hog breeding, and pork consumption accounting for 49.6% of the world's pork consumption. Poultry production is second only to the United States, and it is the ...

Claims

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