Medical application of saikoside D in promoting subcutaneous white fat browning to prevent or treat obesity

A technology of white fat and saikosaponin, applied in the application field of medicine, can solve the problems of saikosaponin D’s medical use to be investigated and no literature report on saikosaponin D

Inactive Publication Date: 2022-02-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The molecular weight of saikosaponin D is 780.98, and its chemical structure is: Saikosaponin D belongs to pentacyclic triterpenoid saponins, which has anti-inflammatory, antibacteria...

Method used

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  • Medical application of saikoside D in promoting subcutaneous white fat browning to prevent or treat obesity
  • Medical application of saikoside D in promoting subcutaneous white fat browning to prevent or treat obesity
  • Medical application of saikoside D in promoting subcutaneous white fat browning to prevent or treat obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The purpose of the experiment: To study the effect of saikosaponin D on the body weight of obese animal models induced by HFD high-fat diet

[0021] Experimental animals: C57BL / 6J mice, male, weighing (20±2) g were used.

[0022] Experimental method: the mice were divided into 4 groups according to body weight, so that there was no significant difference in body weight of each group. The specific grouping conditions are as follows: the first group of 6 rats was given normal diet (Research diet D12450B) as the blank control group (LFD); the second group of 6 rats was given HFD diet (Research diet D12492) as the model group (HFD); The third group of 6 rats was given HFD diet and Metformin at the same time, 200mg / kg / d, as the positive drug group (HFD+Met); the fourth group of 6 rats was given HFD diet at the same time as the dose of 10mg / kg / d Saikosaponin D, as a saikosaponin D treatment group (HFD+SSD). After 12 weeks of normal or high-fat diet, the mice were ...

Embodiment 2

[0029] Purpose of the experiment: To study the effect of saikosaponin D on adipose histology in animal models of obesity induced by HFD high-fat diet

[0030] Experimental animals: C57BL / 6J mice, male, weighing (20±2) g were used.

[0031] Experimental method: the mice were divided into 4 groups according to body weight, so that there was no significant difference in body weight of each group. The specific grouping conditions are as follows: the first group of 6 rats was given normal diet (Research diet D12450B) as the blank control group (LFD); the second group of 6 rats was given HFD diet (Research diet D12492) as the model group (HFD); The third group of 6 rats was given HFD diet and Metformin at the same time, 200mg / kg / d, as the positive drug group (HFD+Met); the fourth group of 6 rats was given HFD diet at the same time as the dose of 10mg / kg / d Saikosaponin D, as a saikosaponin D treatment group (HFD+SSD). After 12 weeks of normal or high-fat diet, the mice we...

Embodiment 3

[0038] The purpose of the experiment: To study the effect of saikosaponin D on the biochemical indicators of HFD obese mouse model

[0039] Experimental animals: C57BL / 6J mice, male, weighing (20±2) g were used.

[0040]Experimental method: the mice were divided into 4 groups according to body weight, so that there was no significant difference in body weight of each group. The specific grouping conditions are as follows: the first group of 6 rats was given normal diet (Research diet D12450B) as the blank control group (LFD); the second group of 6 rats was given HFD diet (Research diet D12492) as the model group (HFD); The third group of 6 rats was given HFD diet and Metformin at the same time, 200mg / kg / d, as the positive drug group (HFD+Met); the fourth group of 6 rats was given HFD diet at the same time as the dose of 10mg / kg / d Saikosaponin D, as a saikosaponin D treatment group (HFD+SSD). After 12 weeks of normal or high-fat diet, the mice were given saikosaponi...

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PUM

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Abstract

The invention relates to medical application of saikoside D in promoting subcutaneous white fat browning and preventing or treating obesity. The saikoside D is a saponin component extracted from roots and stems of radix bupleuri, and belongs to pentacyclic triterpenoid saponin. A C57BL/6J obese mouse model is induced by using high fat diet, and after saikoside D is given, the weight increase of the mouse is slowed down, the glucose tolerance is improved, the insulin sensitivity of the mouse is enhanced, the contents of serum TC and TG are reduced, the subcutaneous fat cell inflammation is reduced, and the expression of a white fat browning related target gene is up-regulated. Results show that saikosaponin D can prevent and treat obesity by promoting subcutaneous white fat browning. Therefore, saikosaponin D has an important application prospect in preparation of medicines for treating obesity.

Description

[0001] field of invention [0002] The invention relates to a new application field of a chemical saikosaponin D, and discloses its application in the preparation of a drug for promoting the browning of subcutaneous white fat to prevent or treat obesity. [0003] Background of the invention [0004] Adipose tissue is one of the largest organs in the body and plays an important role in regulating the energy homeostasis of the body. Excessive energy intake can lead to excessive accumulation of lipids in adipose tissue and hypertrophy of fat cells. Excessive obesity can bring a series of metabolic diseases. Mammalian adipose tissue can be divided into two categories, white adipose tissue (WAT) and brown adipose tissue (BAT). According to literature reports, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a product of Thermal tissue, which plays a key role in maintaining core body temperature. Under the stimulation of some factors, w...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/04A61P3/06
CPCA61K31/7048A61P3/04A61P3/06
Inventor 徐晓军杨胜也
Owner CHINA PHARM UNIV
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