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Method for extracting and recovering acanthopanax total flavonoids by using deep eutectic solvent

A technology of deep eutectic solvent and Acanthopanax, which is applied in the direction of anti-toxic agents, pharmaceutical formulas, plant raw materials, etc., can solve the problems of destroying the natural environment, threatening human health, easy inhalation and poisoning, and achieve the effect of promoting diffusion and mass transfer. The effect of extraction solvent safety and short time

Active Publication Date: 2022-02-08
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic solvents have the disadvantages of being flammable, volatile, and easy to be inhaled and poisoned, and a large amount of use will damage the natural environment and even threaten human health.

Method used

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  • Method for extracting and recovering acanthopanax total flavonoids by using deep eutectic solvent
  • Method for extracting and recovering acanthopanax total flavonoids by using deep eutectic solvent
  • Method for extracting and recovering acanthopanax total flavonoids by using deep eutectic solvent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) a preparation method of a novel eutectic, comprising the following steps:

[0055] 1) Stir and mix 1 mol of glycerol and 1 mol of levulinic acid under a constant temperature heating condition of 85°C, the stirring speed is 200r / min, and mix for 1.5h to obtain a deep eutectic solvent;

[0056] 2) Take 7mL of deep eutectic solvent in a centrifuge tube, add 3mL of water, stir and mix at a constant temperature of 85°C at a stirring speed of 200r / min, and mix for 1.5h to obtain an extract with a water content of 30%.

[0057] (2) a method for extracting the total flavonoids of Radix Acanthopanax, comprising the following steps:

[0058] 1) The Acanthopanax senticosus decoction pieces are ground into powder with a pulverizer, passed through an 80-mesh sieve, and stored at room temperature;

[0059] 2) Add 0.5 g of Acanthopanax acanthopanax powder into 10 mL of the extract according to the ratio of material to liquid 1:20, stir and mix, the stirring speed is 200 r / min, an...

Embodiment 2

[0064] (1) a preparation method of a novel eutectic, comprising the following steps:

[0065] 1) Stir and mix 1 mol of glycerin and 1 mol of levulinic acid under a constant temperature heating condition of 90° C. at a stirring speed of 200 r / min, and mix for 1.5 hours to obtain a deep eutectic solvent;

[0066] 2) Take 6.5mL of deep eutectic solvent in a centrifuge tube, add 3.5mL of water, stir and mix at a constant temperature of 90°C at a stirring speed of 200r / min, and mix for 1.5h to obtain an extract with a water content of 35%. liquid.

[0067] (2) a method for extracting the total flavonoids of Radix Acanthopanax, comprising the following steps:

[0068] 1) The Acanthopanax senticosus decoction pieces are ground into powder with a pulverizer, passed through an 80-mesh sieve, and stored at room temperature;

[0069] 2) Add 0.5 g of Acanthopanax acanthopanax powder into 7.5 mL of the extract according to the ratio of material to liquid 1:15, stir and mix, the stirring ...

Embodiment 3

[0074] (1) a preparation method of a novel eutectic, comprising the following steps:

[0075] 1) Stir and mix 1 mol of glycerol and 1 mol of levulinic acid under a constant temperature heating condition of 80°C, the stirring speed is 200r / min, and mix for 1.5h to obtain a deep eutectic solvent;

[0076] 2) Take 7.2mL of deep eutectic solvent in a centrifuge tube, add 2.8mL of water, stir and mix at a constant temperature of 80°C at a stirring speed of 200r / min, and mix for 1.5h to obtain an extract with a water content of 28%. liquid.

[0077] (2) a method for extracting the total flavonoids of Radix Acanthopanax, comprising the following steps:

[0078] 1) The Acanthopanax senticosus decoction pieces are ground into powder with a pulverizer, passed through an 80-mesh sieve, and stored at room temperature;

[0079] 2) Add 0.5 g of Acanthopanax acanthopanax powder into 9 mL of the extract according to the ratio of material to liquid of 1:18, stir and mix, the stirring speed i...

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Abstract

The invention belongs to the technical field of extraction and purification of effective components of traditional Chinese medicines, and particularly discloses a method for extracting and recycling acanthopanax total flavonoids by using a deep eutectic solvent. The method comprises the following steps: by taking powder of acanthopanax roots as a raw material, adding a deep eutectic solvent with a certain water content, extracting acanthopanax total flavonoids under an ultrasonic-assisted condition, and enriching and recovering flavonoid compounds in an extracting solution by using macroporous resin, and meanwhile, after the water in the obtained eutectic recovery liquid is evaporated, extracting the acanthopanax total flavonoids again, wherein the acanthopanax total flavonoids can be repeatedly utilized for at least three times. The invention develops a novel process technology for extracting and enriching the acanthopanax total flavonoid compounds from the acanthopanax roots and stems by combining the eutectic solvent with the macroporous resin, the recycling of the eutectic solvent is realized, and the purposes of greenness, high efficiency and repeatable extraction are achieved. Compared with a traditional extraction method, the method has the advantages of no use of an organic solvent, simplicity and convenience in operation, time saving, safety, low cost and the like, and industrial production can be realized.

Description

technical field [0001] The invention belongs to the technical field of extracting and purifying effective components of traditional Chinese medicine, and relates to a method for extracting and recovering total flavonoids of Acanthopanax senticosus with a deep eutectic solvent, in particular to a new type of ultrasonic-assisted deep eutectic solvent combined with macroporous adsorption resin from the rhizome of Acanthopanax senticosus A method for extracting and purifying total flavonoids from Acanthopanax. Background technique [0002] Acanthopanax is a shrub belonging to the Araliaceae family. It is widely distributed in Russia, South Korea, Japan and Northeast China in Asia. Its roots, stems, leaves, flowers and fruits all have pharmacological activity and are often used as various functional preparations. Acanthopanax contains a large number of biologically active ingredients, such as eleutheroside, flavonoids, polysaccharides and polyphenols, etc., which are the materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P39/06A61P39/00A61P9/00A61P1/00A61K125/00
CPCA61K36/254A61P39/06A61P39/00A61P9/00A61P1/00A61K2236/333A61K2236/55Y02P20/54Y02A50/30
Inventor 褚秀玲张馨予苏建青
Owner LIAOCHENG UNIV
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