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Composition with multi-target scalp itching relieving effect

A technology of composition and extract, which is applied in the field of daily chemicals to reduce irritation, improve the efficiency of scalp itching relief, and have good anti-allergic effect

Pending Publication Date: 2022-02-18
SHENZHEN LANTERN SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current research, natural product extracts have become a key research field for scalp antipruritic, but the current reports may focus on a scalp antipruritic target, such as antibacterial or oil control, and there is no research on oil control, antibacterial and antipruritic. A natural extract composition for scalp itching combined with three sensitive targets

Method used

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  • Composition with multi-target scalp itching relieving effect
  • Composition with multi-target scalp itching relieving effect
  • Composition with multi-target scalp itching relieving effect

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0073] The preparation method of Sophora japonica bud extract is as follows: dry Sophora japonica flower buds to constant weight, pulverize, pass through a 60-mesh sieve, and extract with 70% ethanol solution under reflux for 3 hours according to the ratio of material to liquid (g / mL) of 1:6. Stir continuously; filter, collect the filtrate, and repeatedly reflux extract the residue with 70% ethanol solution for 3 hours, filter, combine the two filtrates, and centrifuge the filtrate at 5000r / min for 15min; take the supernatant and concentrate it in a rotary evaporator until it is alcohol-free odor; the concentrated extract is placed on a D101 type macroporous adsorption resin column, eluted with 80% ethanol solution at a flow rate of 1mL / min, and the eluate is collected; the eluate is concentrated in a rotary evaporator until it has no alcohol smell, A thick paste is obtained; the thick paste is freeze-dried to obtain the Sophora japonica bud extract.

[0074] The preparation m...

Embodiment 1

[0078] Example 1 Aesculus aesculus extract inhibits sebum secretion

[0079] 1. Human sebocytes inhibit sebum secretion experiment

[0080] Human sebocytes SZ95 were cultured, and after the cells entered the logarithmic growth phase, they were digested with trypsin, dispersed with DMEM medium, counted with a hemocytometer, and diluted with DMEM medium to a concentration of 20×10 4 cells / mL; the diluted cell suspension was added to a 96-well plate, each well was 100 μL, that is, 2×10 4 per well, placed at 37°C, 5% CO 2 cultured in an incubator for 24 hours; removed the medium, washed 3 times with PBS, and divided the cell lines into a control group (a pure cell group in DMEM medium), a positive control group (each well contained 100 μM stimulators (oleic acid and Linoleic acid was mixed at a molar ratio of 1:1 and prepared with dimethyl sulfoxide)), Aesculus aesculus extract treatment group (each well contained 100 μM stimulator and 0.05 μg / mL, 0.1 μg / mL, 0.2 μg / mL Aesculus ...

Embodiment 2

[0085] Example 2 Antibacterial ability of Sophora flavescens root extract to Propionibacterium acnes

[0086] Using the inhibition zone method (refer to "Disinfection Technical Specifications" 2002 Edition) to investigate the antibacterial ability of Sophora flavescens root extract on Propionibacterium acnes, and compare it with the natural plant extracts (Multileaf Artemisiae Argyi Extract) that are currently recognized as having a higher antibacterial effect bacteriostatic activity of Propionibacterium acnes. The result is as Figure 4As shown, at the same concentration (50mg / mL), the diameter of the inhibition zone of Sophora flavescens root extract is: 14.35±0.64mm, the inhibition zone of Artemisia argyi leaf extract is: 8.36±0.56mm, and the antibacterial zone of honeysuckle extract The circle is: 4.93±0.53mm. It can be seen that the ability of the three extracts to inhibit Propionibacterium acnes is: Sophora flavescens root extract > Artemisia argyi leaf extract > Honeys...

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Abstract

The invention belongs to the technical field of daily chemicals, and discloses a composition with a multi-target scalp itching relieving effect. The invention specifically discloses application of a sophora flower bud extract in preparation of a product for inhibiting hyaluronidase activity, the sophora flower bud extract provided by the invention has an obvious inhibiting effect on hyaluronidase, the inhibition rate of 0.5mg / mL sophora flower bud extract on hyaluronidase can reach 50%, and the sophora flower bud extract can effectively regulate and control tissue permeability in an intercellular matrix, regulate the inflammation reaction, and has good anti-allergy effect.

Description

technical field [0001] The invention belongs to the technical field of daily-use chemicals, and in particular relates to a composition with multi-target scalp and antipruritic effects. Background technique [0002] With the aggravation of urban environmental pollution, irregular life schedule, and mental stress brought about by busy work, unhealthy scalp condition has become a common problem that both male and female consumers are increasingly concerned about. At present, the concept of scalp care is gradually gaining popularity, and the proportion of scalp care products in hair care products is also increasing year by year. According to a market survey, scalp itching is the most important scalp health problem among consumers after dandruff. [0003] The scalp skin of the human body is not significantly different from ordinary skin in terms of tissue structure, but the thickness of the scalp is only 1 / 6 of that of the facial skin. At the same time, the scalp is rich in seba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61Q17/00A61Q5/00A61Q5/02A61Q5/12A61P17/10A61P17/04
CPCA61K8/9789A61Q19/00A61Q17/005A61Q19/008A61Q5/008A61Q5/02A61Q5/12A61P17/10A61P17/04A61K2800/782
Inventor 孙亚娟杨成梅杰
Owner SHENZHEN LANTERN SCI
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