Liver organoid and preparation method therefor

Abstract

The present invention relates to a liver organoid and, more specifically, to a liver organoid in which a liver lobule-type structure can be maintained for a long time and a preparation method therefor. The liver organoid of the present invention comprises: a tubular outer cavity the inside of which is divided into a plurality of compartments; a cell aggregate loaded into the compartments; and an inner cavity located at the core of the outer cavity.

Description

Technical field [0001] The present disclosure relates to the liver type organ, and more particularly to the liver type organ and preparation method thereof in which the liver leaflet can be maintained for a long time. Background technique [0002] The development of new drugs requires a lot of time, efforts, and considerable cost. However, when successful, high value can be created. In order to effect the drug, the drug must reach the target site at a concentration sufficient to show its effect. However, when the drug metabolized in the liver, the drug lost its activity. [0003] Drug-induced liver toxicity mechanism is closely related to liver metabolism. Drug-induced liver toxicity is the cause of the new drug development and stop clinical trial in clinical stages in the clinical stage. In addition, when the drug-induced liver toxicity is found even after the drug is listed, the drug is withdrawn from the market. Therefore, the three-dimensional liver model developed for toxici...

AI Technical Summary

Problems solved by technology

However, conventional bioprinting techniques have limitations in printing resolution and, in the case of preparing large structures, oxygen reduction due to stacking

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