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Liver organoid and preparation method therefor

A technology of organoids and livers, which is applied in the field of liver organoids and its preparation, can solve problems such as printing resolution limitations, achieve the effect of preventing cell death and achieving long-term culture

Pending Publication Date: 2022-02-22
T&R BIOFAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional bioprinting techniques have limitations in printing resolution and, in the case of preparing large structures, oxygen reduction due to stacking

Method used

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  • Liver organoid and preparation method therefor
  • Liver organoid and preparation method therefor
  • Liver organoid and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] [Example 1] Preparation of the first biological ink

[0067] The first biological ink was prepared by adding vascular endothelial cells to the neutralized pH 6.0-8.0 and stirred.

Embodiment 2

[0068] [Example 2] Preparation of second biological ink

[0069] The second biological ink is prepared by adding adult liver stem cells to the neutralized pH 6.0-8.0 and stirred.

Embodiment 3

[0070] [Example 3] Preparation of the third biological ink

[0071] The third biological ink is prepared by adding the alginate to the distilled water and stirred at room temperature for 12 hours.

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PUM

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Abstract

The present invention relates to a liver organoid and, more specifically, to a liver organoid in which a liver lobule-type structure can be maintained for a long time and a preparation method therefor. The liver organoid of the present invention comprises: a tubular outer cavity the inside of which is divided into a plurality of compartments; a cell aggregate loaded into the compartments; and an inner cavity located at the core of the outer cavity.

Description

Technical field [0001] The present disclosure relates to the liver type organ, and more particularly to the liver type organ and preparation method thereof in which the liver leaflet can be maintained for a long time. Background technique [0002] The development of new drugs requires a lot of time, efforts, and considerable cost. However, when successful, high value can be created. In order to effect the drug, the drug must reach the target site at a concentration sufficient to show its effect. However, when the drug metabolized in the liver, the drug lost its activity. [0003] Drug-induced liver toxicity mechanism is closely related to liver metabolism. Drug-induced liver toxicity is the cause of the new drug development and stop clinical trial in clinical stages in the clinical stage. In addition, when the drug-induced liver toxicity is found even after the drug is listed, the drug is withdrawn from the market. Therefore, the three-dimensional liver model developed for toxici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/209B33Y80/00C09D11/04C12M3/00C12N5/071
CPCB29C64/209B33Y80/00C09D11/04C12M21/08C12M3/00C12N5/067C12N5/0697C12N2502/28C12N2533/54C12N2533/74C09D11/08C09D11/14C12N2502/14C12N2533/56C12N2535/00B33Y10/00B33Y70/00B29C64/118B29C64/40C12N5/0062C12N5/0671C12N2513/00
Inventor 陈炂完安根先姜东求
Owner T&R BIOFAB