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DMMR subtype classification method and system based on pathological image

A technology of pathological images and classification methods, applied in the field of medical pathological image processing, can solve problems such as results and dependencies affecting pathological research

Pending Publication Date: 2022-03-11
北京知见生命科技有限公司 +1
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Problems solved by technology

[0002] In the process of pathological research on tumors, researchers usually obtain the living body of the suspected tumor area through puncture or surgery, make pathological sections, and obtain pathological results through microscope reading. This method relies heavily on the accumulated experience of researchers. ; In addition, some errors in the production process will affect the results of pathological research

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  • DMMR subtype classification method and system based on pathological image
  • DMMR subtype classification method and system based on pathological image
  • DMMR subtype classification method and system based on pathological image

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Embodiment Construction

[0020] In order to make the present invention, it is more apparent to the following examples, and the accompanying drawings are described in detail below.

[0021] The present invention provides a method of subtyping dMMR pathological image based on the image size is too large for the pathology, the problem can not be directly subjected to classification, multi-scale network area of interest identified by different training image scale information, image caused effective filtration context interference by the neural network model and combined with machine learning methods classify the region of interest (ROI) image segmented into blocks of uniform size, wherein the expression of extracting image block using a neural network, the PCA extracted feature reduction, increase the operating speed of subsequent operations. After all of the same drop image Weihou Te intrinsic pathological feature fusion input random forest, to give the final classification result.

[0022] The present inve...

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Abstract

The invention provides a dMMR subtype classification method based on a pathological image, and the method comprises the steps: dividing a labeled pathological image, obtaining a plurality of known image blocks, constructing a data set, training a deep learning network through the data set, and obtaining a region-of-interest recognition model; obtaining a target image region of a target pathological image through the region-of-interest recognition model; dividing the target image area into a plurality of target image blocks with the same size, averagely dividing all the target image blocks into a plurality of parts, and carrying out stacking and merging operation on each part of the target image blocks to obtain stacked blocks; and obtaining feature representations of all the stacked blocks, and obtaining a dMMR subtype classification result of the target pathological image according to all the feature representations. The invention further provides a dMMR subtype classification system based on the pathological image and a data processing device used for carrying out dMMR subtype classification on the target pathological image.

Description

Technical field [0001] The present invention relates to medical pathology image processing technology, and particularly relates to an image based on the depth study pathological classification method and system. Background technique [0002] Pathological study of tumor processes, researchers often experience acquired by the living body area suspected tumor, making pathology, and the results obtained by microscopic pathology interpretation, this approach relies heavily accumulated by researchers researchers puncture or surgical ; in addition, some errors in the production process will affect the results of the pathological study. Accordingly, a computer-implemented method for pre-treatment pathological image, by normalizing pathological image and dMMR (DNA mismatch repair defects, different Mismatch Repair) subtype classification, thereby reducing the workload of researchers, while to reduce the subjective and objective factors causing the problem of pathological bias the results....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06V10/774G06V10/25G06V10/26G06V10/46G06V10/82G06V10/764G06V10/77G06N3/04G06N3/08G16H30/20G16B25/10G16B40/00
CPCG06N3/08G16H30/20G16B40/00G16B25/10G06N3/045G06F18/2135G06F18/24323G06F18/214
Inventor 赵娜吴焕文窦晋津杜保林王晓雯
Owner 北京知见生命科技有限公司
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