Lactobacillus fermentum and application of product of lactobacillus fermentum in oxidation resistance and tumor resistance

A Lactobacillus fermentum, anti-oxidation technology, applied in the direction of Lactobacillus, anti-tumor drugs, applications, etc., to achieve the effect of anti-oxidation and inhibition of tumor cell proliferation, significant tumor cell proliferation, and simple methods

Pending Publication Date: 2022-03-18
THANKCOME BIOLOGICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on how to efficiently utilize the active ingredients in grape skin for anti-oxidation or anti-tumor effects

Method used

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  • Lactobacillus fermentum and application of product of lactobacillus fermentum in oxidation resistance and tumor resistance
  • Lactobacillus fermentum and application of product of lactobacillus fermentum in oxidation resistance and tumor resistance
  • Lactobacillus fermentum and application of product of lactobacillus fermentum in oxidation resistance and tumor resistance

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Embodiment 1

[0041] 1. Materials and methods

[0042] 1. Sample processing

[0043] Fresh Kyoho grape skins are vacuum-dried and ground into powder through a 500-mesh sieve. Fermentation group: Dissolve 10g grape skin powder and 1g white sugar in 100mL ultrapure water, then add 1mL 1×10 7 CFU / mL Lactobacillus fermentum CQPC04 (LF-CQPC04) was inoculated in the solution, strain control group: inoculate 1mL 1×10 7 CFU / mL Lactobacillus delbrueckii subsp. bulgaricus (China Microorganism Culture Collection Center, preservation number: CGMCC NO.1.16075). The solution was fermented at 37°C in a shaker at 100 rpm. After 24, 48, 72, 96 and 120 h, the solution was centrifuged at 12000 rpm for 10 min, and then the supernatant was collected and stored at -80°C. For the blank control group, 10 g of grape skin powder was dissolved in 100 mL of 60% ethanol solution, and placed in a water bath at 70° C. for 4 h. The precipitate was discarded by centrifugation, and the solution was rotary evaporated (R...

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Abstract

The invention discloses application of lactobacillus fermentum and a product thereof in oxidation resistance and tumor resistance, and belongs to the technical field of application of natural products. In particular discloses application of lactobacillus fermentum and a product thereof in preparation of antioxidant drugs, food or health care products, and application of lactobacillus fermentum and a product thereof in preparation of antitumor drugs, food or health care products, the lactobacillus fermentum is lactobacillus fermentum CQPC04, and the preservation number is CGMCC NO.14493; the lactobacillus fermentum product is obtained by fermenting grape skin with lactobacillus fermentum CQPC04. Experimental verification shows that compared with chemical components fermented by other strains or directly extracted by chemical reagents, the obtained fermentation product of the grape skin fermented by the lactobacillus fermentum CQPC04 has the effects of remarkably improving oxidation resistance and inhibiting liver cancer cell proliferation.

Description

technical field [0001] The invention relates to the technical field of application of natural products, in particular to the application of Lactobacillus fermentum and its products in anti-oxidation and anti-tumor. Background technique [0002] Many free radicals are produced through respiration and metabolism. Under normal physiological conditions, the production of free radicals and the antioxidant system are in a state of dynamic balance in the body. When the accumulation of free radicals exceeds the protective capacity of the antioxidant system, the balance is broken, manifested as oxidative stress. Studies have shown that oxidative stress can damage various macromolecules in cells (such as polysaccharides, proteins, lipids, and DNA), and oxidative stress can also stimulate signaling pathways involved in apoptosis, inflammatory responses, changes in cell functions, and ultimately Pathological changes leading to diseases such as Parkinson's disease, Alzheimer's disease a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P39/06A61P35/00A23L33/00A23L33/135A23L29/00A61K131/00
CPCA61K36/87A61P39/06A61P35/00A23L33/00A23L33/135A23L29/065A61K2236/19A23V2002/00A23V2400/143A23V2200/30A23V2200/308
Inventor 马新赵欣刘佳喻扬郁雪平
Owner THANKCOME BIOLOGICAL SCI & TECH CO LTD
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