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Application of Xintong preparation in preparation of medicine for treating chronic bronchitis and preparation method of Xintong preparation

A technology for chronic bronchitis and preparations, applied in the field of traditional Chinese medicine, can solve the problems of high recurrence rate, treating the symptoms but not the root cause, and large side effects.

Pending Publication Date: 2022-03-29
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, western medicine can only play a certain role in controlling the acute attack of the disease, and because most of them are antibiotics, long-term use will produce drug resistance, side effects are large, the symptoms are not cured, and the recurrence rate is high

Method used

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  • Application of Xintong preparation in preparation of medicine for treating chronic bronchitis and preparation method of Xintong preparation
  • Application of Xintong preparation in preparation of medicine for treating chronic bronchitis and preparation method of Xintong preparation
  • Application of Xintong preparation in preparation of medicine for treating chronic bronchitis and preparation method of Xintong preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] The preparation of embodiment 1 Xintong capsule

[0102]

[0103] A. Weigh the thirteen medicinal materials of Astragalus, Codonopsis, Ophiopogon japonicus, Polygoni multiflorum, Epimedium, Pueraria lobata, Angelica, Salvia miltiorrhiza, Saponaria thorn, seaweed, kelp, oyster, and Citrus aurantium, among which Ophiopogon japonicus, Epimedium, Citrus aurantium Net selection, Codonopsis pilosula, seaweed, and kelp are cleaned and cut into sections; Polygonum multiflorum, Pueraria root, and oyster are cleaned and cut into pieces; Astragalus, Angelica, and Salvia are cleaned and sliced;

[0104] B. Take Radix Puerariae and Salvia miltiorrhiza, add 7 times the amount of 80% ethanol to reflux twice, each time for 1.5 hours, filter, combine the filtrates to obtain alcohol extract I, set aside, and the dregs for set aside;

[0105] C. Step B Pueraria root, Danshen herbal dregs and the rest of astragalus, Codonopsis radix, Ophiopogon japonicus, Polygonum multiflorum, Epimediu...

Embodiment 2

[0108] The preparation of embodiment 2 Xintong oral liquid

[0109]

[0110] A. Weigh the thirteen medicinal materials of Astragalus, Codonopsis, Ophiopogon japonicus, Polygoni multiflorum, Epimedium, Pueraria lobata, Angelica, Salvia miltiorrhiza, Saponaria thorn, seaweed, kelp, oyster, and Citrus aurantium, among which Ophiopogon japonicus, Epimedium, Citrus aurantium Net selection, Codonopsis pilosula, seaweed, and kelp are cleaned and cut into sections; Polygonum multiflorum, Pueraria root, and oyster are cleaned and cut into pieces; Astragalus, Angelica, and Salvia are cleaned and sliced;

[0111] B. Take Radix Puerariae and Salvia miltiorrhiza, add 8 times the amount of 60% ethanol to reflux twice, each time for 2.5 hours, filter, combine the filtrates to obtain alcohol extract I, set aside, and the dregs for set aside;

[0112] C. Step B Pueraria root, Danshen dregs and the rest of astragalus, Codonopsis radix, Ophiopogon japonicus, Polygonum multiflorum, Epimedium, ...

Embodiment 3

[0115] Preparation of Example 3 Xintong Granules

[0116]

[0117]

[0118] A. Weigh the thirteen medicinal materials of Astragalus, Codonopsis, Ophiopogon japonicus, Polygoni multiflorum, Epimedium, Pueraria lobata, Angelica, Salvia miltiorrhiza, Saponaria thorn, seaweed, kelp, oyster, and Citrus aurantium, among which Ophiopogon japonicus, Epimedium, Citrus aurantium Net selection, Codonopsis pilosula, seaweed, and kelp are cleaned and cut into sections; Polygonum multiflorum, Pueraria root, and oyster are cleaned and cut into pieces; Astragalus, Angelica, and Salvia are cleaned and sliced;

[0119] B. Take Radix Puerariae and Salvia miltiorrhiza, add 8 times the amount of 70% ethanol to reflux twice, each time for 2 hours, filter, combine the filtrates to obtain alcohol extract I, set aside, and the dregs for set aside;

[0120] C. Step B Pueraria root, Danshen dregs and the rest of astragalus, Codonopsis radix, Ophiopogon japonicus, Polygonum multiflorum, Epimedium, ...

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Abstract

The invention discloses application of a Xintong preparation in preparation of a medicine for treating chronic bronchitis and a preparation method of the Xintong preparation, and belongs to the technical field of traditional Chinese medicines. The Xintong preparation is prepared from thirteen raw medicinal materials including radix astragali, radix codonopsis, radix ophiopogonis, radix polygoni multiflori, herba epimedii, radix puerariae, radix angelicae sinensis, radix salviae miltiorrhizae, spina gleditsiae, seaweed, kelp, concha ostreae and fructus aurantii immaturus, and has the effects of tonifying qi, activating blood, diminishing inflammation and reducing phlegm. Pharmacodynamic tests show that the Xintong preparation has anti-inflammatory, asthma-relieving and cough-relieving effects, can effectively improve physical conditions of chronic bronchitis rats, such as lassitude, weakness, intake loss and weight loss, can significantly reduce the level of lung tissue homogenate TNF-alpha of the chronic bronchitis rats, and meanwhile, can increase the levels of IL-10 and IL-4, and can improve the curative effect of the chronic bronchitis rats. The traditional Chinese medicine has an exact and remarkable treatment effect on chronic bronchitis.

Description

technical field [0001] The invention relates to the application of Xintong preparation and its preparation method, in particular to the application of Xintong preparation in the preparation of medicines for treating chronic bronchitis and its preparation method, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Chronic bronchitis is chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues caused by infection or non-infection factors. Clinically, it is characterized by cough, expectoration or chronic process accompanied by wheezing and recurrent attacks, and its pathological features are bronchial gland hyperplasia and increased mucus secretion. Chronic bronchitis is a common clinical disease with a high incidence rate, slow disease progression, repeated attacks, and a long course of disease. If it is not treated in time, it may be complicated by obstructive emphysema, bronchiectasis, and even pul...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16A61K9/50A61P11/00A61K35/618
CPCA61K36/481A61K36/344A61K36/8968A61K36/704A61K36/296A61K36/488A61K36/232A61K36/537A61K36/483A61K36/02A61K36/03A61K35/618A61K36/752A61K9/1652A61K9/5052A61P11/00A61K2236/333A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 关永霞林雪竹苗宇
Owner LUNAN HOPE PHARM CO LTD
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