A method for simultaneous detection of multiple components in Daqili preparation
A multi-component and preparation technology, applied in the direction of measuring devices, material separation, and analysis of materials, can solve the problems of irregular feeding, incomplete quality control, and inability to identify, achieve good repeatability, solve quality control blind spots, and prevent adulteration fake effect
Active Publication Date: 2022-05-31
江西省药品检验检测研究院
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Problems solved by technology
There are few reports on the quality research of Daqili preparations, especially the research on the adulteration and irregular feeding of Daqili preparations, which has not been reported in the literature
At present, for adulterated samples, only according to the current standard inspection items of Daqili preparations, the quality cannot be completely controlled, and the situation of irregular feeding cannot be identified.
Method used
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Effect test
Embodiment 1
[0063] The sample volume was 10 μL; the flow rate was 1.0 mL / min.
[0066] Due to the complexity and diversity of Chinese medicinal components, the UV absorption wavelengths of different chemical components are different. Visible-purple
Embodiment 2
[0078]
[0079] The results showed that rhein showed a good linear relationship between 0.04024 and 0.3353 μg.
[0083]
[0084] The results showed that Lourein B showed a good linear relationship between 0.04 and 0.3333 μg.
[0088]
[0089] The results showed that the rosin acid showed a good linear relationship between 0.0152 and 0.1267 μg.
[0093]
[0094] The results showed that 11-carbonyl-β-acetylboswellic acid showed a good linear relationship between 0.01589~0.1324 μg.
[0098]
[0103]
[0104] The results show that the method has good repeatability for each component of the measured sample.
[0108]
[0113]
[0115]
[0117]
[0119]
Embodiment 4
[0132]
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The invention belongs to the field of quality detection of traditional Chinese medicines, and specifically relates to a method for simultaneously detecting multiple components in Daqili preparations. The method adopts HPLC method to carry out content determination and result judgment on the mixed reference substance solution and the test solution respectively. Alkylsilane-bonded silica gel is used as a chromatographic column filler, acetonitrile is used as mobile phase A, 0.1% formic acid solution is used as mobile phase B, and gradient elution is carried out. The number of theoretical plates is not less than 4000 according to the peak of rhizoma glucoside; the control The product solution contains abietic acid, rhizomatin, ascarin B and 11-carbonyl-β-acetylboswellic acid. The present invention establishes a method capable of simultaneously detecting multiple components in Daqili preparations. The method has good separation effect, good repeatability, low detection limit, fast and accurate, simple and efficient, and low cost, and can be used as a method for controlling adulteration of Daqili preparations. The technical means of adulterating and irregular feeding.
Description
A method for simultaneous detection of multiple components in Daqili preparations technical field The invention belongs to the field of quality detection of traditional Chinese medicines, be specifically related to a kind of method for simultaneously detecting multiple components in Daqili preparations. Law. Background technique Daqili preparation includes Daqili powder, Daqili tablet, Daqili capsule and Daqili pill four dosage forms, and the prescription contains Rhubarb, dried blood, frankincense, myrrh, soft-shelled turtle, natural copper, drynaria, angelica tail, borax, panax notoginseng, borneol, and eleven herbs. The original powder is used as medicine. In recent years, driven by commercial interests, many counterfeit Chinese medicines have appeared on the market, among which Rhubarb, which is widely used, and frankincense, myrrh and dried blood, which have historically relied on imports and are in short supply. Polygonaceae plant palm leaves The dried root...
Claims
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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 吴良发姜军华任琦许妍王欢张利群郑盈莹
Owner 江西省药品检验检测研究院
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