Preparation method of iron-based metal organic framework composite material with MOF-On-MOF framework, obtained product and application

An iron-based metal and organic framework technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of increasing the burden on normal tissues and organs, drug leakage, low loading, etc. problems, to achieve the effects of avoiding early leakage, increasing drug loading, and enhancing porosity

Active Publication Date: 2022-04-29
SUN YAT SEN UNIV CANCER CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research on these drug carriers has made some progress, there are still some problems: 1) low drug loading requires a large dose to achieve a certain therapeutic effect, which will increase the burden on normal tissues and organs; 2) controlled release Unsatisfactory effect, leading to unnecessary early leakage of drugs, causing serious side effects; 3) Too complicated drug delivery system introduces more external substances, which poses a serious threat to biosafety
The preparation conditions of the former are relatively simple, but it is difficult to realize the controlled release of drugs in diseased tissues
This disadvantage can be well avoided by the latter, but the latter also faces the disadvantages of cumbersome preparation process and low loading capacity

Method used

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  • Preparation method of iron-based metal organic framework composite material with MOF-On-MOF framework, obtained product and application
  • Preparation method of iron-based metal organic framework composite material with MOF-On-MOF framework, obtained product and application
  • Preparation method of iron-based metal organic framework composite material with MOF-On-MOF framework, obtained product and application

Examples

Experimental program
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Effect test

Embodiment 1

[0041] (1) Using the solvothermal method, add 18 mg of the organic ligand 2-aminoterephthalic acid into 10 mL of absolute ethanol, dissolve it completely by ultrasonication, and then add 27 mg of ferric chloride hexahydrate. Keep stirring at a constant speed for 1.5 hours at 40°C, collect and centrifuge and wash with absolute ethanol for 3 to 5 times to obtain 3 mg metal-organic framework material NH 2 -MIL-88B.

[0042] (2) the above-prepared NH 2 - All MIL-88B was ultrasonically dispersed in 10 mL of absolute ethanol, and then 9 mg of organic ligand 2-aminoterephthalic acid and 13.5 mg of ferric chloride hexahydrate were ultrasonically dissolved in the mixed solution. The reaction was stirred at a uniform speed for 1.5 hours, and 5.5 mg of MOF-On-MOF iron-based metal-organic framework composite material, namely MIL-On-MIL, was obtained.

Embodiment 2

[0044] (1) Using the solvothermal method, add 18 mg of the organic ligand 2-aminoterephthalic acid into 10 mL of absolute ethanol, dissolve it completely by ultrasonication, and then add 27 mg of ferric chloride hexahydrate. Keep stirring at a constant speed for 1.5 hours at 40°C, collect and centrifuge and wash with absolute ethanol for 3 to 5 times to obtain 3 mg metal-organic framework material NH 2 -MIL-88B.

[0045] (2) the above-prepared NH 2 -All of MIL-88B was ultrasonically dispersed in absolute ethanol (10 mL) containing doxorubicin hydrochloride (5 mg), followed by sequential addition of 9 mg of organic ligand 2-aminoterephthalic acid and 13.5 mg of trichloride hexahydrate Iron was ultrasonically dissolved in the mixed solution, and stirred at a constant speed for 1.5 hours at 40°C to obtain 6.4 mg of MOF-On-MOF-structured iron-based metal-organic framework material DOX@MIL-On-MIL, referred to as DMM.

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Abstract

The invention discloses a preparation method of an iron-based metal organic framework composite material with an MOF-On-MOF framework, an obtained product and application, the iron-based metal organic framework composite material is synthesized by adopting an MOF-On-MOF strategy, then drugs such as doxorubicin hydrochloride are loaded in double-layer MOF-On-MOF pore cavities, and the drug-loaded iron-based metal organic framework composite material is obtained. The synthesized composite material is uniform in size, the second MOF layer not only improves the drug loading capacity, but also can be used as a gating entity, and premature drug leakage is avoided. The composite material has good pH and GSH response capability, has peroxidase-like catalytic activity under an acidic condition, can catalyze H2O2 to generate. OH, shows the potential of chemodynamic therapy for treating cancers, well expands the demand of combined treatment of cancers by using chemotherapy and chemodynamic therapy in the practical application field, and has a wide application prospect. And possibility is provided for clinical application.

Description

technical field [0001] The invention relates to a preparation method of an iron-based metal-organic framework composite material with a MOF-On-MOF structure, and relates to a MOF-On-MOF with peroxidase-like activity under acidic conditions and good pH / GSH responsiveness The preparation method of the iron-based metal-organic framework composite material of the framework also relates to the product obtained according to the method and the application of the product as a drug carrier in chemotherapy and chemodynamic therapy combined treatment of cancer tissue. Background technique [0002] Traditional chemotherapy is still one of the important methods of tumor treatment. However, poor cellular uptake of a single drug, short half-life of the drug, and nonspecific distribution in organisms severely limit its therapeutic efficacy. In order to overcome these obstacles, drug delivery carriers such as polymers, molecular vesicles, and mesoporous silicon have attracted extensive atte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K47/34A61K31/704A61P35/00
CPCC08G83/008A61K47/34A61K31/704A61P35/00
Inventor 谢曼修
Owner SUN YAT SEN UNIV CANCER CENT
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