58 results about "Doxorubicin hcl" patented technology

The invention relates to a method for preparing a graphene oxide double-targeting medicine carrier material, and a medicine loaded by the carrier material. The method is used for preparing the carrier material and the loaded medicine. The invention solves the problems that the conventional nano-medicine carrier has a complicated structure, is high in synthetic cost and low in efficiency, and cannot be massively prepared easily. The method for preparing the graphene oxide double-targeting medicine carrier material comprises the following steps of: preparing carboxymethylated graphene oxide; preparing a graphene oxide-biologically targeting molecule composite; and preparing the graphene oxide double-targeting medicine carrier material, wherein the loaded medicine is one or more of doxorubicin hydrochloride, paclitaxel, hydroxycamptothecine and daunomycin.

The invention relates to an ATP responding type drug-releasing nano gel and a preparation method thereof, and belongs to the technical field of medicine. The nano gel is composed of carboxymethyl chitosan, DNA 1 with carboxyl modified terminals, DNA 2 with carboxyl modified terminals, and an ATP aptamer. Amino groups of carboxymethyl chitosan react with carboxyl groups of terminals of single chain DNA 1 and DNA2 to form stable amide bonds; because the ATP aptamer can carry out complementary base pairing with single chain DNA 1 and DNA2, the ATP aptamer can be used as a gel crosslinking agent, which can realize the crosslinking of nano gel; through physical embedding, doxorubicin hydrochloride is embedded in the GC segment of nucleic acid, the drug encapsulation is realized; and a novel ATP responding type drug-releasing nano gel drug delivering system is prepared. The system can respond to the high concentration ATP in tumor cell and competitively combines with the gel crosslinking agent (ATP aptamer); thus the complementarily paired nucleic acid chains are broken, the gel skeleton is broken, and drugs are released. The provided nano gel can improve the safety and targeting property of a tumor drug delivery system to a certain degree.

The invention discloses a preparation method of drug-loadable polyvinyl alcohol eluted microspheres, and relates to the field of biological medicinal materials. Preparation comprises the following steps: (1) preparing a certain concentration of a polyvinyl alcohol aqueous solution, and then adding 2-acrylamide-2-methylpropanesulfonic acid and N,N-methylene bisacrylamide, and stirring evenly by magnetic force; and (2) with persulfate and sulfite as an oxidation-reduction initiation system and glutaraldehyde as a curing agent, preparing the modified polyvinyl alcohol microspheres with the particle size of 100-700 [mu]m by an inverse micro-suspension crosslinking method, namely the drug-loadable polyvinyl alcohol eluted microspheres. Because the microspheres contain a large number of sulfonic acid groups, the microspheres can be effectively loaded with positively charged drugs such as doxorubicin hydrochloride as vascular embolization agents.

The invention belongs to the technical field of biomedical materials, and particularly relates to a photo-thermal sensitive carboxymethyl chitosan nano drug-loaded microsphere, a nano microsphere is formed by taking a polymer carboxymethyl chitosan / N-isopropylacrylamide as a skeleton and loading hydrazone bond bonded nanogold-doxorubicin hydrochloride on the surface of the skeleton. The inventionalso provides a preparation method of the nano drug-loaded microsphere. The invention provides the photo-thermal sensitive carboxymethyl chitosan nano drug-loaded microsphere, the problem that chitosan is difficult to dissolve in water is solved, meanwhile, by changing the conditions of near-infrared illumination and temperature, the nano microsphere material is subjected to phase change, hydrophilic chain collapse and solvation layer damage, a medicine is slowly released, the medicine carrying rate of the medicine is increased, and the medicine is controlled to be accurately released.

The invention provides TA-Fe (III) modified PLGA nanoparticles coating doxorubicin hydrochloride and a preparation method thereof. The mPEG-PLGA is selected as a carrier material, TA and Fe (III) are used as modification materials, and the nanoparticles are prepared by combination of a multiple emulsion-solvent volatilization method and coordination modification of the TA and Fe (III). The encapsulation efficiency of the nanoparticles is 80.14+ / -9.79%, and the drug loading is 0.85+ / -0.08%. The particle size of the nanoparticles is 146.9+ / -14.3 nm, the Zeta potential is -21.0+ / -0.2 mV, and the polydispersity index is 0.214+ / -0.113. The surfaces of the nanoparticles obtained by the preparation method are smooth and round without adhesion, and the nanoparticles have controllable size, small particle size and narrow range of particle size, are convenient for intravenous injection, and have good sustained release effect. The TA-Fe (III) modified nanoparticles have a good drug encapsulation effect, can significantly reduce drug burst release and have a pH responsiveness effect. Therefore, the nanoparticles have broader application prospects in targeted delivery as an anti-tumor drug.

The invention belongs to a method for preparing composite micro-spheres with Fe3O4@C core-shell structures and application of the composite micro-spheres. The method includes preparing Fe2O3 nano-particles by the aid of modified solvothermal processes; preparing morphologically controllable composite micro-spheres with Fe2O3@ppy core-shell structures by the aid of combinations of template processes, hydrothermal processes and ultrasonic assisting processes without optional surfactants under mild conditions; reducing the morphologically controllable composite micro-spheres with the Fe2O3@ppy core-shell structures under the protection of nitrogen atmosphere to obtain the composite micro-spheres with the Fe3O4@C core-shell structures and superparamagnetism. The method and the application have the advantages that doxorubicin hydrochloride is used as a medicine model to carry out medicine loading and release tests, and the composite micro-spheres are excellent in medicine sustained-release and controlled-release performance as shown in the tests; the composite micro-spheres with the magnetic composite F3O4@C core-shell structures has a sustained-release function and the superparamagnetism which are integrated with each other, and accordingly the composite micro-spheres can have broad application prospects in the biomedical field of targeted therapy and the like.

The invention provides pH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel. A preparation method of the silver nano-cluster hydrogel comprises the following steps: (1), an AgNO3 solution is prepared, placed in a microwave reactor, stirred and heated, a cysteine solution is added dropwise, and a silver nano-cluster dispersing agent is prepared through reaction; (2), a citric acid solution is added to the silver nano-cluster dispersing agent, the mixture is placed on a small shaking table and subjected to ultraviolet irradiation, an NaHCO3 solution is added to regulate pH after the solution is transparent, high-speed centrifugation is performed, doxorubicin hydrochloride powder is added, the mixture is placed in a high-pressure reactor, nitrogen is introduced, the pressure and the temperature in the reactor are adjusted, red and clear jelly, namely, the pH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel, is obtained through reaction. The silver nano-cluster hydrogel is taken as a carrier to coat doxorubicin hydrochloride and is injected to a tumor position through orthotopic injection, the pH of the tumor position is responded, so that slow drug release is realized, the tumor inhibition rate is increased, and cardiac toxicity is reduced.

The invention discloses a preparation method of surface-functionalized elution micro-spheres capable of carrying drugs, relating to the field of bio-medical materials. The preparation method comprises the following steps: (1) by taking carboxymethyl chitosan as a raw material and polyethylene glycol diglycidyl ether as a cross-linking agent, preparing cross-linking carboxymethyl chitosan micro-spheres of which the particle sizes are mainly distributed in 300-400mu m by a reverse micro-suspension cross-linking method; and (2) putting the prepared dry cross-linking carboxymethyl chitosan micro-spheres into an aqueous solution of 2-acrylamide-2-methylpropanesulfonic acid for soaking, and carrying out graft polymerization on the 2-acrylamide-2-methylpropanesulfonic acid on the surfaces of the micro-spheres by taking ammonium ceric nitrate as an initiator, so as to modify the micro-spheres. As the surfaces of the micro-spheres, modified by graft polymerization, have a large number of sulfonic acid groups, drugs with positive charges, such as doxorubicin hydrochloride, can be effectively carried, so that the elution micro-spheres can be hopefully prepared.

This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. These orotate derivatives are equally efficacious in inhibiting the SCCAKI-1 kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HCl suggests a reduction in toxicity induced by free radical generation by the anthracyclines.

The invention relates to a preparation method of amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response. Thiolated chitosan, carboxymethyl chitosan, sodium tripolyphosphate, doxorubicin hydrochloride and hydrogen peroxide are taken as raw materials. The preparation method comprises the following steps: mixing a thiolated chitosans solution with a doxorubicin hydrochloride solution so as to obtain a solution I; mixing a carboxymethyl chitosan solution with a sodium tripolyphosphate solution so as to obtain a mixed solution II; dropwise adding the mixed solution I into the mixed solution II while stirring, controlling the dosage of carboxymethyl chitosan and thiolated chitosan, regulating the ph value of the solution to 6-8, performing ultrasonic blending, performing ion crosslinking and polymer condensing, then dropwise adding hydrogen peroxide into the system so as to finish oxidization crosslinking, performing room-temperature stirring reaction, separating products, and drying the products to obtain the amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response. The amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response is capable of escaping away from tumor cell endosome / lysosome, is capable of automatically regulating and controlling to realize cytoplast release based on unique microenvironments of tumor cells, improving the amycin medicine delivery efficiency and the medical effect, and has a favorable research and development application background in multiple aspects such as medicine and medical materials.

This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. There orotate derivatives are equally efficacious in inhibiting the SCCAKI-1 kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HCl suggests a reduction in toxicity induced by free radical generation by the anthrracyclines.

The invention discloses a dual-signal electrochemical sensor for detecting a doxorubicin hydrochloride rate based on a bare glassy carbon electrode. A specific detection method comprises the steps of immersing the glassy carbon electrode into phosphatic water buffer solution containing DOX and methylene blue (MB), correlating a ratio delta IDOX / delta IMB between the electrochemical signal intensities of two substrates with the concentration of the DOX, and drawing a linear standard curve; measuring an SWV signal of a sample containing the DOX and the MB and determining the content of the DOX in serum according to the drawn standard curve. The prepared dual-signal electrochemical sensor for detecting the DOX rate based on the bare glassy carbon electrode is simple to operate, high in flexibility and good in stability and has important significance in detecting the dosage of the DOX in the serum of a cancer patient.

The invention discloses a preparation method of antigen determinant / doxorubicin hydrochloride (DOX) double-template molecularly imprinted fluorescent nanoparticles with an alpha-helix structure. Fluorescent nano silicon spheres wrapping silicon nano-particles are used as a carrier, P32 protein N-terminal conformation 9 peptides and doxorubicin hydrochloride are used as double-template molecules, and the double-molecular imprinted nano particles are prepared by adopting a precipitation polymerization method. According to the invention, the Si nano particles are wrapped in silicon dioxide to prepare fluorescent nano silicon spheres and the fluorescent double-template molecularly imprinted nano particles, and the fluorescence characteristic can be used for fluorescence imaging of tumor cells.A polypeptide with an alpha-helix structure constructed by using trifluoroethanol is used as a template molecule, so that target identification of target tumor cells can be effectively improved. Thenano particles are prepared by adopting the conformation polypeptide and the doxorubicin hydrochloride as double templates, targeted medicine delivery is realized while targeted specific recognition of tumor cells is realized, the amount of medicines reaching target sites is increased, side effects are reduced, the medicine utilization rate is improved, and the treatment effect is enhanced.

The invention relates to microspheres with a liver active targeting function and pH and reduction stimulative responsiveness, a preparation method thereof, and an application of the microspheres in medicine. The microspheres are characterized in that: (1) a carrier is composed of galactose modified gelatin and poly(beta-amino ester), and the microspheres are prepared through an emulsion cross-linking method with galactose modified gelatin and linear poly(beta-amino ester) containing a disulfide bond as monomers, and dialdehyde as a crosslinking agent, wherein a terminal group of the linear poly(beta-amino ester) is a secondary amino group; (2) the drug-loaded microspheres are prepared through the following steps: with an antineoplastic drug, the galactose modified gelatin and the poly(beta-amino ester) as components, dispersing doxorubicin hydrochloride as a model drug of the antineoplastic drug into the monomers, i.e., the galactose modified gelatin and the linear poly(beta-amino ester), then adding the crosslinking agent, and subjecting the two monomers to a crosslinking reaction so as to form the microspheres; and (3) the prepared microspheres have good recognition properties to liver cells and good pH and reduction stimulative release properties to model drugs, and can be further researched and developed into a novel targeting preparation used for treatment of liver cancer.

The invention provides a pH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and a preparation method thereof. A structure of the drug controlled release system includes that the system is of a double-layer structure, the inner layer of the system is provided with a drug-loading magnetic meso-porous silicon nano-particle, the outer layerof the system is provided with a branched polyethyleneimine, the branched polyethyleneimine of the outer layer is treated by methylmaleic anhydride, the magnetic meso-porous silicon nano-particle is of a core-shell structure, a core is provided with a ferroferric oxide nano-particle, and a loaded drug is doxorubicin hydrochloride. The system has magnetic responsiveness, cell tracing is achieved, disease conditions are accurately diagnosed in real time, targeted delivery and controlled release of the drug is synchronously achieved, amidated PEI wraps surface of MMSN through GSH (glutathione) sensitive disulfide bonds, so that 'passive targeting' enrichment of acid response of a tumor microenvironment is achieved, step-by-step response is achieved by the aid of a mechanism of pH sensitivityand GSH sensitivity, high-accuracy targeted therapy of a cancer is achieved, and the cancer is effectively and integrally diagnosed and treated.

The invention provides a near-infrared exothermic acid-base responsive coaxial fiber for controlled release of doxorubicin hydrochloride and a preparation method, the coaxial fiber comprises a doxorubicin hydrochloride core layer and a shell fiber layer with a hollow structure, the shell fiber layer is prepared by spinning a shell fiber layer spinning solution, the shell fiber layer spinning solution is prepared by mixing poly L-lactide-caprolactone, gelatin, a sodium bicarbonate saturated solution and copper sulfide nanocrystals; the nanofiber with the near-infrared heat release doxorubicin hydrochloride chemotherapy function is designed through coaxial coating, the nanofiber reacts with hydrogen ions around a tumor affected part by combining a pH-sensitive drug sodium bicarbonate to generate carbon dioxide, pores are formed in the surface of the fiber during release, therefore, the efficient release of the doxorubicin hydrochloride in the core layer in the acidic environment of the tumor tissue is realized, and the controlled release effect is realized; the nano copper sulfide in the shell layer absorbs and converts near-infrared light penetrating through a human body into heat and oxygen, and the heat release treatment and drug chemotherapy have a synergistic effect, so that effective treatment of tumors is realized.

This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. There orotate derivatives are equally efficacious in inhibiting the SCCAKI-1 kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HCl suggests a reduction in toxicity induced by free radical generation by the anthrracyclines.

The invention discloses a modified carboxymethyl chitosan microsphere as well as a preparation method and application thereof. The preparation method comprises the following steps of firstly, preparing poly(N-acryloyl taurine), then adding the poly(N-acryloyl taurine) into a carboxymethyl chitosan solution to form a mixed solution, and finally, preparing the carboxymethyl chitosan and poly(N-acryloyl taurine) interpenetrating network microsphere by a suspension crosslinking method. According to the preparation method provided by the invention, the poly(N-acryloyl taurine) is formed by polymerizing monomer N-acryloyl taurine; the density of sulfonic acid groups is relatively high; in a structural unit of the poly(N-acryloyl taurine), negative charge carried by the sulfonic acid groups of side chains interact with drug molecules with positive charge; and the groups are introduced into an embolism microsphere, so that the drug loading rate of the microsphere on an anti-cancer drug doxorubicin hydrochloride can be obviously improved.

The invention provides a sulfydryl-containing zwitterionic polypeptide modified doxorubicin derivative, a nano-micelle and a preparation method of the nano-micelle, and belongs to the field of biological medicines. The doxorubicin derivative has a structure as shown in a general formula (I). The preparation method of the doxorubicin derivative comprises the following steps of in a polar solvent, mixing sulfydryl-containing zwitterionic polypeptide with acryloylhydrazine to react, and performing crystallizing to obtain a polypeptide derivative; and dissolving the polypeptide derivative and doxorubicin hydrochloride in the polar solvent according to a molar ratio of 1: (0.2-5), adding a trifluoroacetic acid catalyst, and carrying out a stirring reaction to obtain the doxorubicin derivative.The nano-micelle prepared from the doxorubicin derivative is long in in-vivo blood circulation time, high in drug loading capacity, small in toxic and side effects, good in pH value response and goodin tumor inhibition effect.

The invention discloses a pH-response drug-loaded self-assembly aquagel-formed polypeptide, a preparation method and use. An amino acid sequence of the polypeptide is Ile-Glu-Ile-Ile-Ile-Orn. Aquagel is formed through dissolving the polypeptide in an aqueous solution, carrying out swirling until the polypeptide is dissolved so as to form a polypeptide solution, adjusting a pH, and carrying out standing gelatination at room temperature. The obtained polypeptide aquagel is good in biocompatibility, high in mechanical properties and low in toxic or side effects; and the polypeptide aquagel disclosed by the invention has relatively high sensitivity to the pH, the aquagel loading doxorubicin hydrochloride is implanted to a focus region in an injection manner, the drug-loaded polypeptide aquagel can achieve targeted sustained / controlled release of a drug under the stimulation of an acidulous environment of a tumor, the antitumor treatment effect of the drug is improved, and the drug-loaded polypeptide aquagel is free of toxic or side effects on normal tissue.

The invention relates to a redox response polypeptide hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention provides a polypeptide that can be self-assembled to form hydrogel, the polypeptide is dissolved in water and then forms a redox response hydrogel under crosslinking of H2O2. The hydrogel has a compact fiber network structure, relatively strong mechanical properties and good biocompatibility. The hydrogel has high sensitivity to glutathione (GSH), and the GSH responsive release of the drug can be realized by loading the doxorubicin hydrochloride into the hydrogel. The drug-loaded hydrogel is implanted into a tumor part through injection, so that the anti-tumor effect of the drug can be improved, and the toxic and side effects of the drug on normal tissues are effectively reduced.

The invention provides a preparation method and application of a medicine-carrying nano-diamond compound, wherein the method comprises the following steps: 1) mixing nano-diamond with water to prepare a first solution; 2) mixing doxorubicin hydrochloride with water to prepare a second solution; 3) mixing the first solution with the second solution to prepare a third solution; 4) adding a sodium hydroxide aqueous solution into the third solution to react completely; 5) centrifuging a reaction liquid, and collecting a sediment to prepare a doxorubicin-nano-diamond compound; 6) mixing the compound with water to prepare a fourth solution; 7) mixing the fourth solution with an all-transretinoic acid, then adding isopropanol or dimethylsulfoxide to react to prepare a fifth solution; and 8) centrifuging the fifth solution, and collecting a sediment to prepare the medicine-carrying nano-diamond compound. The two kinds of medicines are used in a combination manner, the growth and the metastasis of a tumor are inhibited, and the life of a living body is prolonged.

The invention discloses erythrocyte membrane coated drug-loaded nanoparticles / probes and application thereof in diagnosis and treatment of glioblastoma. The erythrocyte membrane coated drug-loaded nanoparticles are obtained by coating an erythrocyte membrane of a human or animal with doxorubicin hydrochloride-loaded poly(lactic-co-glycolic acid) (PLGA). The nanoparticles obtained by the invention have the characteristics of similar particle size and shape, capability of providing a relatively stable internal environment, long circulation time in blood in an animal body, biocompatibility, high targeted accumulation content in a tumor and the like, tumor diagnosis can be realized through fluorescence imaging, and a drug can be released at a tumor part; tumor growth is inhibited in vivo, and the survival time of animals is prolonged.

The invention discloses a double-drug co-loaded liposome containing erianin and doxorubicin as well as preparation and application of the double-drug co-loaded liposome. The double-drug co-loaded liposome containing erianin and doxorubicin is composed of a liposome loaded with erianin and doxorubicin hydrochloride and a folic acid-chitosan cross-linked polymer modified outer layer. The invention provides the application of the double-drug co-loaded liposome containing erianin and doxorubicin in preparation of anti-cancer drugs. The two drugs are loaded on the same carrier to be delivered, the cancer cell inhibiting capacity can be enhanced, the application cost is reduced, and the toxic effect on normal cells is weak.

The invention discloses a preparation method of an iron-based metal organic framework composite material with an MOF-On-MOF framework, an obtained product and application, the iron-based metal organic framework composite material is synthesized by adopting an MOF-On-MOF strategy, then drugs such as doxorubicin hydrochloride are loaded in double-layer MOF-On-MOF pore cavities, and the drug-loaded iron-based metal organic framework composite material is obtained. The synthesized composite material is uniform in size, the second MOF layer not only improves the drug loading capacity, but also can be used as a gating entity, and premature drug leakage is avoided. The composite material has good pH and GSH response capability, has peroxidase-like catalytic activity under an acidic condition, can catalyze H2O2 to generate. OH, shows the potential of chemodynamic therapy for treating cancers, well expands the demand of combined treatment of cancers by using chemotherapy and chemodynamic therapy in the practical application field, and has a wide application prospect. And possibility is provided for clinical application.

The invention discloses a method for loading medicines on tumor targeted amorphous calcium phosphate fluorescence nanocomposite materials. The method comprises the steps of firstly with hyaluronic acid (HA) as a raw material, preparing partially-carbonized hyaluronic acid fluorescent materials HA-FCNs (HA fluorescence carbon nanoparticles) by a high temperature dehydration method; and then with calcium nitrate as a calcium source, diammonium hydrogen phosphate as a phosphorus source and HA-FCNs as a marker, preparing the tumor targeted amorphous calcium phosphate fluorescence nanocomposite materials (HA-FCNs / ACP) by a coprecipitation method. Besides, curcumin (Cur) is used as a lyophobic medicine model, doxorubicin hydrochloride (DOX) is used as a hydrophilic medicine model, and loading oftwo medicines is realized. The medicine carrier prepared by the method disclosed by the invention is good in biocompatibility, has obvious biological imaging and pH responsiveness, has targeting properties on cancer cells (A549 cells), has obvious enzymatic release reactions in cancer cell internal environment, and significantly reduces cancer cell viability.

The invention discloses a preparation method of zein / calcium carbonate composite particles. The preparation method comprises the following steps of sufficiently dispersing the zein in 70%-90% alcohol liquor, adding calcium chloride and stirring and dissolving to form mixed liquor of calcium chloride and the zein, then, adding sodium carbonate liquor with amount of substance equal to that of calcium chloride, stirring at a high speed until the liquor is light blue; and then, keeping final concentration of the zein to 0.1g.L<-1> to 10 g.L<-1> by controlling addition amount of the zein, dialyzing and purifying to obtain the zein / calcium carbonate composite particles. Controlled release performance experiments of doxorubicin hydrochloride indicate that the zein / calcium carbonate composite particles have very good medicine carrying performance and controlled release performance to water-soluble small molecule drugs, and therefore, the zein / calcium carbonate composite particles can be used as water-soluble small molecule drug carriers for being used for producing pharmaceutical preparations.

The invention discloses a lignin-based pH response type magnetic nano-drug carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, carrying out amination modification on sodium lignin sulfonate through Mannich reaction, so that the sodium lignin sulfonate becomes amphiphilic macromolecules with pH responsiveness; then compounding by using cyclohexane and ethanol as oil phases and lignin and a magnetic Fe3O4 aqueous solution as an aqueous phase through an inverse emulsion crosslinking method; and finally, adding a cross-linking agent to react to obtain the composite nano-carrier. Lignin molecules can be uniformly cross-linked on Fe3O4 nano-particles in a reversed-phase suspension, the synthesized drug-loaded nano-particles are good in monodispersity, the particle size can be lower than 200 nm, the morphology is spherical, the drug loading rate and the release rate are high, and a constructed drug delivery system provides valuable data and reference for accurate control and treatment of cancers and has good application prospects. And a theoretical basis is provided for clinical application of doxorubicin hydrochloride targeted therapy.

The invention discloses a phase-change nano composite material with bubbles promoting drug release, a preparation method and application. The nano material takes mesoporous silica coated gold nanorod GNR@mSiO2 with an ordered pore structure as a carrier, a temperature-sensitive phase-change material and doxorubicin hydrochloride DOX are loaded in the pore structure of the nano particle to obtain PFP@GNR@mSiO2-DOX, and the outermost layer of the PFP@GNR@mSiO2-DOX is coated with a polydopamine layer to obtain an FPF@GNR@mSiO2-DOX@PDA composite material. the nano material is uniform in particle morphology, has a photothermal effect, and is good in water solubility and biocompatibility. The invention also discloses a preparation method and application of the material. The nano diagnosis and treatment agent material is prepared on the basis of gold nanorods and a seed mediation method through synchronous improvement of materials and processes, and the prepared composite material is good in stability and morphology uniformity, has good water solubility and biocompatibility, has a photothermal effect, has the attribute of collaborative treatment of tumor photothermal treatment and rapid chemotherapy, and the method can be applied to the field of quick release of drugs.

The invention discloses a polyurethane foam based on graphene modification, and particularly relates to the technical field of polyurethane foam. The polyurethane foam is prepared from the following raw materials: polyether polyol, polyester polyol, isocyanate, modified graphene, a foaming agent, a catalyst and a foam stabilizer. Graphene is modified by utilizing isocyanate and doxorubicin hydrochloride, an isocyanate group is introduced to the surface of graphene, the isocyanate group can react with polyether polyol, the purpose of modifying polyurethane foam by graphene polymerization is achieved, doxorubicin hydrochloride is loaded on graphene by utilizing an ultrasonic oscillation mode, a hydrogen bond can be formed between graphene and doxorubicin hydrochloride, the mechanical strength of the polyurethane foam can be effectively improved under the action of an isocyanate group and the hydrogen bond, and doxorubicin hydrochloride contained in the polyurethane foam can effectively achieve antibacterial and bacteriostatic effects, so that the use requirements of people can be met.