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PH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and preparation method thereof

A nanoparticle, drug controlled release technology, applied in the direction of pharmaceutical formulation, drug combination, drug delivery, etc., can solve the impact of MRI imaging, stop in vitro test and animal test, dispersion, stability, biocompatibility, lack of biological toxicity Evaluation system and other issues to achieve the effect of increasing targeting, reducing toxic and side effects, and achieving the best therapeutic effect

Active Publication Date: 2019-03-08
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (1) With the increase of in vivo circulation time, Fe in the magnetic mesoporous silica carrier system 3 o 4 Some will be oxidized to Fe 2 o 3 , which will have a certain impact on MRI imaging;
[0008] (2) The magnetic mesoporous silicon carrier system is still in the research and development stage. The system lacks a corresponding evaluation system in terms of dispersion, stability, biocompatibility, and biotoxicity. It is necessary to establish relevant nanomaterials and technical standards as a guide;
[0009] (3) The research on the magnetic mesoporous silicon carrier system belongs to medicine. This research is bound by objective conditions and ethics. It is impossible to test the efficacy and safety of the system through clinical trials in a short period of time. The controlled release of the carrier system stops at in vitro tests and Animal experiments, these results cannot fully and truly reflect the situation of human experiments, so it brings a lot of inaccuracy to the evaluation of magnetic mesoporous silicon carrier system

Method used

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  • PH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and preparation method thereof
  • PH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and preparation method thereof
  • PH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0072] 1. Preparation of Fe3O4 nanoparticles (OA-Fe3O4)

[0073] The preparation steps of OA-Fe3O4 are as follows: 13.12g FeCl3·6H2O and 6.65g FeCl2·4H2O were sequentially dissolved in 80mL deionized water, heated to 80°C under nitrogen atmosphere, and vigorously stirred for 0.5h. Then 45 mL of NH3·H2O solution (25 wt%) was added dropwise, the resulting suspension was vigorously stirred for 5 min, then 2 mL of oleic acid was added, and the reaction was allowed to continue stirring for 25 min. The resulting crude product was separated by magnet to give a colorless solution in the upper layer and a tarry black magnetic gel precipitated. The magnetic gel is repeatedly washed with deionized water and ethanol, and then dried in a vacuum drying room to obtain oleic acid-stabilized ferric oxide nanoparticles (OA-Fe3O4).

[0074] 2. Preparation of Magnetic Mesoporous Silicon Nanoparticles (CTAB-MMSN)

[0075] Disperse 7.5 mg of OA-Fe3O4 in 0.5 mL of chloroform, then add to 5 mL of d...

Embodiment 2

[0093] 1. Preparation of Fe3O4 nanoparticles (OA-Fe3O4)

[0094] The preparation steps of OA-Fe3O4 are as follows: 13.67g FeCl3·6H2O and 7.32g FeCl2·4H2O were sequentially dissolved in 90mL deionized water, heated to 80°C under nitrogen atmosphere, and vigorously stirred for 0.5h. Then 50 mL of NH3·H2O solution (25 wt%) was added dropwise, the resulting suspension was vigorously stirred for 5 min, then 2 mL of oleic acid was added, and the reaction was allowed to continue stirring for 25 min. The resulting crude product was separated by magnet to give a colorless solution in the upper layer and a tarry black magnetic gel precipitated. The magnetic gel is repeatedly washed with deionized water and ethanol, and then dried in a vacuum drying room to obtain oleic acid-stabilized ferric oxide nanoparticles (OA-Fe3O4).

[0095] 2. Preparation of Magnetic Mesoporous Silicon Nanoparticles (CTAB-MMSN)

[0096] Disperse 7.5 mg of OA-Fe3O4 in 0.5 mL of chloroform and then add to 5 mL o...

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Abstract

The invention provides a pH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and a preparation method thereof. A structure of the drug controlled release system includes that the system is of a double-layer structure, the inner layer of the system is provided with a drug-loading magnetic meso-porous silicon nano-particle, the outer layerof the system is provided with a branched polyethyleneimine, the branched polyethyleneimine of the outer layer is treated by methylmaleic anhydride, the magnetic meso-porous silicon nano-particle is of a core-shell structure, a core is provided with a ferroferric oxide nano-particle, and a loaded drug is doxorubicin hydrochloride. The system has magnetic responsiveness, cell tracing is achieved, disease conditions are accurately diagnosed in real time, targeted delivery and controlled release of the drug is synchronously achieved, amidated PEI wraps surface of MMSN through GSH (glutathione) sensitive disulfide bonds, so that 'passive targeting' enrichment of acid response of a tumor microenvironment is achieved, step-by-step response is achieved by the aid of a mechanism of pH sensitivityand GSH sensitivity, high-accuracy targeted therapy of a cancer is achieved, and the cancer is effectively and integrally diagnosed and treated.

Description

technical field [0001] The invention relates to the field of drug controlled release, in particular to the field of a pH-responsive magnetic mesoporous silicon nanoparticle drug controlled release system and a preparation method thereof. technical background [0002] In recent years, due to its unique electrical and magnetic properties and stable physical and chemical properties, superparamagnetic ferroferric oxide nanoparticles have been widely used in magnetic recording materials, high gradient magnetic separation, microwave absorption materials, special coatings, catalyst carriers, medicine and other fields. have been widely applied. [0003] Among them, the magnetic mesoporous silicon nanoparticles prepared with superparamagnetic iron ferric oxide nanoparticles as the core and mesoporous silica as the shell have attracted more and more attention in imaging-guided therapy, because the carrier has magnetic response characteristics and can Track the pharmacokinetic process...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/04A61K47/02A61K47/34A61K31/704A61P35/00A61K49/08A61K49/18
CPCA61K9/5115A61K9/5146A61K9/5192A61K31/704A61K49/08A61K49/183A61P35/00
Inventor 李草万立辉陈重银陈辉
Owner HUBEI UNIV
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