Method for preparing composite micro-spheres with Fe3O4@C core-shell structures and application of composite micro-spheres

A technology of composite microspheres and core-shell structures, applied in the field of biomedical materials, can solve the problems of unfavorable magnetic particle distribution, changing particle surface properties, reducing biocompatibility, etc., and achieving the effect of good drug sustained release performance.

Inactive Publication Date: 2016-07-20
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, because the magnetic particles themselves are magnetic, they are easy to agglomerate, which is not conducive to the distribution of magnetic particles in the body.
Now, the common way to reduce agglomeration is to add surfactants, but this method not only changes the surface properties of the particles and affects their load-carrying capacity, but also reduces the biocompatibility due to the presence of surfactants

Method used

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  • Method for preparing composite micro-spheres with Fe3O4@C core-shell structures and application of composite micro-spheres
  • Method for preparing composite micro-spheres with Fe3O4@C core-shell structures and application of composite micro-spheres
  • Method for preparing composite micro-spheres with Fe3O4@C core-shell structures and application of composite micro-spheres

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Embodiment 1

[0026] a kind of Fe 3 o 4 The preparation method of C core-shell structure composite microsphere comprises the following steps: 1. FeCl 3 ·6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 200°C for 4 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 60°C to obtain Fe 2 o 3 Nanospheres (Fe 2 o 3 Scanning electron microscope and transmission electron microscope photos of the nanospheres are as follows: figure 1 -2, the microspheres are regularly arranged, the size is about 200nm, and has good monodispersity); ②The Fe prepared in step ① 2 o3 Disperse the nanospheres in 65vol% ethanol according to the solid-to-liquid ratio of 1g:450ml, ultrasonically treat for 30min at 25°C, then add the ethanol solution of pyrrole, add hydrochloric acid under ...

Embodiment 2

[0042] a kind of Fe 3 o 4 The preparation method of C core-shell structure composite microsphere comprises the following steps: 1. FeCl 3 ·6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 180°C for 8 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 55°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Disperse the nanospheres in 10vol% ethanol according to the solid-to-liquid ratio of 1g:300ml, ultrasonically treat for 60min at 20°C, then add the ethanol solution of pyrrole, add hydrochloric acid under stirring conditions, react at room temperature for 50min, and use the solid obtained after the reaction with Washed with ethanol, washed with water, and dried at 60°C to obtain Fe 2 o 3 ppy composite microspheres; ③ t...

Embodiment 3

[0046] a kind of Fe 3 o 4 The preparation method of C core-shell structure composite microsphere comprises the following steps: 1. FeCl 3 ·6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 220°C for 6 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 65°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Disperse the nanospheres in 35vol% ethanol according to the solid-to-liquid ratio of 1g:500ml, ultrasonically treat for 40min at 30°C, then add the ethanol solution of pyrrole, add hydrochloric acid under stirring conditions, and react for 150min at room temperature. Washed with ethanol, washed with water, and dried at 60°C to obtain Fe 2 o 3 ppy composite microspheres; ③ the Fe obtained in step ② 2 o 3 The ppy compo...

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Abstract

The invention belongs to a method for preparing composite micro-spheres with Fe3O4@C core-shell structures and application of the composite micro-spheres. The method includes preparing Fe2O3 nano-particles by the aid of modified solvothermal processes; preparing morphologically controllable composite micro-spheres with Fe2O3@ppy core-shell structures by the aid of combinations of template processes, hydrothermal processes and ultrasonic assisting processes without optional surfactants under mild conditions; reducing the morphologically controllable composite micro-spheres with the Fe2O3@ppy core-shell structures under the protection of nitrogen atmosphere to obtain the composite micro-spheres with the Fe3O4@C core-shell structures and superparamagnetism. The method and the application have the advantages that doxorubicin hydrochloride is used as a medicine model to carry out medicine loading and release tests, and the composite micro-spheres are excellent in medicine sustained-release and controlled-release performance as shown in the tests; the composite micro-spheres with the magnetic composite F3O4@C core-shell structures has a sustained-release function and the superparamagnetism which are integrated with each other, and accordingly the composite micro-spheres can have broad application prospects in the biomedical field of targeted therapy and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a Fe 3 o 4 Preparation method and application of C core-shell structure composite microspheres. Background technique [0002] In recent years, with the continuous development of medical technology, drug sustained and controlled release preparations have gradually become the focus of pharmaceutical research, and the key to drug sustained and controlled release technology is the selection of drug carriers. Inorganic nanomaterials, such as mesoporous materials, nanotubes, hollow microspheres, etc., are well-known for their good chemical stability, controllable particle shape and size, easy modification of surface and pores, and unique optical, magnetic, and electrical properties. It has gradually become a research hotspot in the field of drug sustained and controlled release. [0003] The ordered pores of mesoporous carbon have a high specific surface area, can load and transp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/704A61K41/00A61P35/00
CPCA61K9/501A61K31/704A61K41/00
Inventor 王永强程琳虞勇郑海红
Owner HENAN UNIVERSITY
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