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Phase-change nano composite material with bubbles promoting drug release, preparation method and application

A nanocomposite material and composite material technology are applied in phase change nanocomposite materials, synergistic treatment application of tumor photothermal therapy and rapid chemotherapy, and preparation field, and can solve the complex preparation method, high cost, poor stability and morphology uniformity. and other problems, to achieve the effect of high repeatability, small particle size and good morphology uniformity

Inactive Publication Date: 2021-07-30
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the material that combines gold nanorods with microbubbles or nanobubbles has poor stability and shape uniformity, and the preparation method is complicated and costly, and it is difficult to apply to the field of rapid release of drugs

Method used

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  • Phase-change nano composite material with bubbles promoting drug release, preparation method and application
  • Phase-change nano composite material with bubbles promoting drug release, preparation method and application
  • Phase-change nano composite material with bubbles promoting drug release, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] This example provides a bubble-promoted phase-change nanocomposite material for drug release. The nanomaterial uses mesoporous silica with an ordered pore structure to coat gold nanorods GNR@mSiO 2 As a carrier, the temperature-sensitive phase change material and doxorubicin hydrochloride DOX are loaded in the pore structure of the nanoparticle to obtain the composite material PFP@GNR@mSiO 2 -DOX, and its outermost layer is coated with a biocompatible polydopamine layer to prevent drug leakage, resulting in FPF@GNR@mSiO 2 -DOX@PDA composite material; the particle shape of the nanomaterial is uniform, it has photothermal effect, good water solubility and biocompatibility.

[0044] In the composite FPF@GNR@mSiO 2 -DOX@PDA finished dry matter, the temperature-sensitive phase change material is perfluoro-n-pentane, and its mass ratio is 3.0%~5.0%, which is 3% in this embodiment; the mass of doxorubicin hydrochloride DOX accounts for The ratio is 4.0%~5.0%, which is 4% in ...

Embodiment 2

[0053] The bubble-promoted drug release phase-change nanocomposite material, preparation method and application provided in this example are basically the same as in Example 1, except that the composite material FPF@GNR@mSiO 2 -DOX@PDA finished product dry matter, the temperature-sensitive phase change material is perfluoro-n-pentane, its mass proportion is 4.0%; doxorubicin hydrochloride DOX mass proportion is 4.5%.

[0054] The preparation method of the bubble-promoted drug release phase-change nanocomposite provided in this embodiment, and further preparing it into a gold nanorod-based phase-change nano-medicine composite material, includes the following steps:

[0055] (1) Use the seed-mediated method to prepare seeds: take 4.88mL cetyltrimethylammonium bromide (CTAB, 0.1mol / L) and 0.12mL HAuCl 4 ٠3H 2 O (0.01mol / L) was stirred for 10min; then 0.3mL sodium borohydride (0.01mol / L) was added, and mixed well, ready for use. Add 190mL of CTAB (0.1mol / L) solution, 10mL of HAu...

Embodiment 3

[0067] The bubble-promoted drug release phase-change nanocomposite provided in this example, its preparation method and its application are basically the same as those in Examples 1 and 2, except that:

[0068] In the composite FPF@GNR@mSiO 2 -DOX@PDA finished product dry matter, the temperature-sensitive phase change material is perfluoro-n-pentane, which accounts for 5.0% by mass; doxorubicin hydrochloride DOX accounts for 5.0% by mass.

[0069] In the step (1) of the preparation method, for each centrifugation step involved, the centrifugation speed is 13500 r / min, and the centrifugation time is 20 minutes; add an equal volume of deionized water and centrifuge again, the centrifugation speed is 11200 r / min, centrifugation Time 20min, dispersed in 20mL of deionized water.

[0070] In this example, the prepared gold nanorods and nanomaterials modified by mesoporous silicon (GNR@mSiO 2 ), a method applied to photothermal experiments, comprising the following steps:

[0071]...

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Abstract

The invention discloses a phase-change nano composite material with bubbles promoting drug release, a preparation method and application. The nano material takes mesoporous silica coated gold nanorod GNR@mSiO2 with an ordered pore structure as a carrier, a temperature-sensitive phase-change material and doxorubicin hydrochloride DOX are loaded in the pore structure of the nano particle to obtain PFP@GNR@mSiO2-DOX, and the outermost layer of the PFP@GNR@mSiO2-DOX is coated with a polydopamine layer to obtain an FPF@GNR@mSiO2-DOX@PDA composite material. the nano material is uniform in particle morphology, has a photothermal effect, and is good in water solubility and biocompatibility. The invention also discloses a preparation method and application of the material. The nano diagnosis and treatment agent material is prepared on the basis of gold nanorods and a seed mediation method through synchronous improvement of materials and processes, and the prepared composite material is good in stability and morphology uniformity, has good water solubility and biocompatibility, has a photothermal effect, has the attribute of collaborative treatment of tumor photothermal treatment and rapid chemotherapy, and the method can be applied to the field of quick release of drugs.

Description

technical field [0001] The invention relates to the technical field of medical biological nanomaterials, in particular to a phase-change nanocomposite material in which air bubbles promote drug release, a preparation method, and its synergistic application in tumor photothermal therapy and rapid chemotherapy. Background technique [0002] The application of nanomaterials in the biological field is becoming more and more extensive. Its unique physical and chemical properties integrate different therapeutic methods into a single nano-platform. The effective combination of detection methods realizes the combination of more efficient cancer treatment and implementation of diagnosis. In order to make nanomaterials enter the living body better, various issues such as biocompatibility and cytotoxicity of nanomaterials should be considered. Based on these premises, a variety of nanomaterials that can enter the living body have been studied, such as gold nanoparticles (gold nanorods...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/69A61K47/52A61K47/54A61K9/51A61K47/34A61P35/00B82Y5/00B82Y40/00
CPCA61K41/0052A61K31/704A61K47/6925A61K47/52A61K47/54A61K9/5146A61P35/00B82Y5/00B82Y40/00
Inventor 刘金亮付翠平张勇吴昌松曹姣
Owner SHANGHAI UNIV
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