Mineralized material for treating tooth sensitivity and promoting epitaxial growth of enamel and application of mineralized material

Abstract

The invention discloses a mineralization material for treating tooth sensitivity and promoting epitaxial growth of tooth enamel and application of the mineralization material. The mineralization material comprises the following raw materials in parts by weight: 5-72 parts of film-forming protein or polyethylene glycol film-forming protein, 4-67 parts of a water-soluble disulfide bond exchanger and 1-21 parts of a pH regulator. According to the invention, a disulfide bond exchanger (such as cysteine (Cys)) without any toxicity can react with the film-forming protein or pegylated film-forming protein for the first time, and when the protein nano-coating with a mineralization regulating function is formed, a large number of macromolecular protein aggregates cannot be generated to block dentin pores, so that the permeability is better, and the application range is wider. According to the present invention, the composite material can deeply permeate into the exposed dentin pinhole, can reach the depth of 200-500 [mu] m (the sealing depth of the protein coating reacting with TCEP is only about 40 [mu] m), and can reach the deep recess of the pit and the fissure;

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a mineralization material for treating tooth sensitivity and promoting the epitaxial growth of tooth enamel and its application. Background technique [0002] According to statistics, 15.2% to 57.4% of adults are troubled by tooth sensitivity, and the prevalence of dental caries in children is as high as 66.9% to 88.1%. In 2020, the coverage of pit and fissure sealing services for children is only about 22%. Oral and dental health has been increasingly affected. much attention. [0003] Enamel is the hardest outer covering of teeth and the first line of defense to protect dental health. The main component is hydroxyapatite, which is difficult to demineralize in a healthy oral environment. However, when various bacteria are wrapped in food residues for a long time, lactic acid will be produced, and the outermost layer of tooth enamel will undergo irreversible damage. Demine...

AI Technical Summary

Problems solved by technology

[0006] At present, pit and fissure sealants are mainly polymeric resin pit and fissure sealants, but their structure is far from that of enamel itself. The main disadvantages of existing pit and fissure sealants are poor sealing of edges and high loss rate.

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