Marker combination for prognosis evaluation of liver cirrhosis

A prognostic evaluation and marker technology, applied in the field of clinical medicine, can solve the problems of undetermined correlation of exhalation in patients with liver cirrhosis

Pending Publication Date: 2022-05-24
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Relevance of expiratory breath in decompensated cirrhosis patients has not been established

Method used

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  • Marker combination for prognosis evaluation of liver cirrhosis
  • Marker combination for prognosis evaluation of liver cirrhosis
  • Marker combination for prognosis evaluation of liver cirrhosis

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Experimental program
Comparison scheme
Effect test

Embodiment

[0034] 1. Study Participants

[0035] This study complies with the ethical principles of the World Medical Association Declaration of Helsinki. The experimental protocol was approved by the Ethics Committee of the Fifth Medical Center of the Chinese People's Liberation Army General Hospital and registered in the Chinese Clinical Trials Registry with the registration number ChiCTR-ROC-17010 345. April 2017 From January to October 2017, 96 participants, including 66 liver cirrhosis (DC) patients (33 males and 33 females) and 30 healthy volunteers (males), were recruited from the Fifth Medical Center of the Chinese People's Liberation Army General Hospital. 13 and 17 women), and all participants signed informed consent. Healthy volunteers (group C) were confirmed to be healthy through normal routine examinations within half a year. All diagnoses in 66 patients with cirrhosis, including 24 patients with hepatitis B cirrhosis (HLC), 22 patients with alcohol-related cirrhosis (ALC)...

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Abstract

The invention provides a marker combination for prognosis evaluation of liver cirrhosis, and the marker combination comprises (+/-)-3, 5, 5-trimethyl-1-hexanol, dichloromethane, pyridine, gamma-butyrolactone, citronellal, ethyl lactate, guaiacol, methyl linoleate, oxoglutaric acid, (+/-)-erythroisoleucine, 3-phenylpropanal and N-acetyl arylamine, and preferably, the N-acetyl arylamine is N-acetanilide. The invention also provides a method for determining the marker combination.

Description

technical field [0001] The clinical medicine involved in this application, in particular, provides a combination of markers for the assessment of prognosis of liver cirrhosis. Background technique [0002] It is well known that the human body releases a large amount of volatile organic compounds (VOCs), mainly from exhaled air, sweat, skin secretions, urine, feces and saliva, all of which are produced through metabolic pathways. Traditional Chinese medicine and ancient Western physicians, including Hippocrates, believed that exhaled breath was important in both diagnosis and treatment, and used smell as a diagnostic tool. Doctors' olfactory skills are not routinely used in modern medicine, and there is extensive documentation that many diseases, such as cancer, diabetes, respiratory diseases, liver diseases, etc., are associated with unique odors. Recently, a "Super-smeller," a woman who can smell Parkinson's disease before clinical symptoms appear, helped scientists develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72G01N33/68
CPCG01N30/02G01N30/72G01N33/6848G01N33/6893G01N2800/085
Inventor 王睿林牛明王仲霞景婧何婷婷荣文雅
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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